Genetic variation in the visfatin (PBEF1/NAMPT) gene and type 2 diabetes in the Greek population

NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus

“…6,7 However, in the present study no mutation of the NAMPT -948G ⁄ T polymorphism was detected in Chinese Han T2DM patients and healthy controls. These apparent discrepancies imply that there is probably an ethnic difference in the distributive frequency of the NAMPT -948G ⁄ T polymorphism and that the NAMPT -948G ⁄ T polymorphism is possibly unrelated to Chinese T2DM.…”

NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus

“…6,7 However, in the present study no mutation of the NAMPT -948G ⁄ T polymorphism was detected in Chinese Han T2DM patients and healthy controls. These apparent discrepancies imply that there is probably an ethnic difference in the distributive frequency of the NAMPT -948G ⁄ T polymorphism and that the NAMPT -948G ⁄ T polymorphism is possibly unrelated to Chinese T2DM.…”

Pharmacogenetics of Oral Antidiabetic Drugs: Potential Clinical Application

“…Thus, NAMPT may be involved in the repaglinide action. Despite contradictory results were reported about the correlation of NAMPT gene polymorphisms and T2DM susceptibility [34,35], our result showed that -948G>T and -3186C>T polymorphisms are not associated with T2DM susceptibility in Chinese population. However, -3186C>T polymorphism is PGC-1α G1182A rs2970847 GG/ Good drug efficacy [73] PGC-1α G1444A rs8192678 GG/ Good drug efficacy [73] Adiponectin T45G rs2241766 TT/ Good drug efficacy [67] Adiponectin C-11377G CC/ Good drug efficacy [67] UCP2 G-866A GG/ Good drug efficacy [76] TNF-α G-308A GG/ Poor drug efficacy [79] associated with plasma levels of postprandial insulin secretion (PINS) and cholesterol (CHO) in Chinese T2DM patients with repaglinide monotherapy [22].We also found that frequencies of -3186C> T polymorphism in Chinese Han population were different from those in Caucasian populations, thus, different dosages of repaglinide may be used among different populations.…”

No Association between Visfatin (NAMPT) Gene Variants and Metabolic Traits in the Newfoundland Population

“…16 A number of other studies have also found no significant differences in allele, genotype, or haplotype frequencies between type 2 diabetes patients and healthy controls. 18,20,23,31 Interestingly, the study by Bottcher et al did observe a marginally significant association between variation in NAMPT and fasting plasma insulin levels as well as 2-h plasma glucose in 626 Caucasian subjects without type 2 diabetes in quantitative trait analyses. 18 This was in contrast to the study by Zhang et al who did not find any association with fasting glucose or insulin levels in 630 healthy individuals.…”

NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus

“…6,7 However, in the present study no mutation of the NAMPT -948G ⁄ T polymorphism was detected in Chinese Han T2DM patients and healthy controls. These apparent discrepancies imply that there is probably an ethnic difference in the distributive frequency of the NAMPT -948G ⁄ T polymorphism and that the NAMPT -948G ⁄ T polymorphism is possibly unrelated to Chinese T2DM.…”

Pharmacogenetics of Oral Antidiabetic Drugs: Potential Clinical Application

“…Thus, NAMPT may be involved in the repaglinide action. Despite contradictory results were reported about the correlation of NAMPT gene polymorphisms and T2DM susceptibility [34,35], our result showed that -948G>T and -3186C>T polymorphisms are not associated with T2DM susceptibility in Chinese population. However, -3186C>T polymorphism is PGC-1α G1182A rs2970847 GG/ Good drug efficacy [73] PGC-1α G1444A rs8192678 GG/ Good drug efficacy [73] Adiponectin T45G rs2241766 TT/ Good drug efficacy [67] Adiponectin C-11377G CC/ Good drug efficacy [67] UCP2 G-866A GG/ Good drug efficacy [76] TNF-α G-308A GG/ Poor drug efficacy [79] associated with plasma levels of postprandial insulin secretion (PINS) and cholesterol (CHO) in Chinese T2DM patients with repaglinide monotherapy [22].We also found that frequencies of -3186C> T polymorphism in Chinese Han population were different from those in Caucasian populations, thus, different dosages of repaglinide may be used among different populations.…”

No Association between Visfatin (NAMPT) Gene Variants and Metabolic Traits in the Newfoundland Population

“…16 A number of other studies have also found no significant differences in allele, genotype, or haplotype frequencies between type 2 diabetes patients and healthy controls. 18,20,23,31 Interestingly, the study by Bottcher et al did observe a marginally significant association between variation in NAMPT and fasting plasma insulin levels as well as 2-h plasma glucose in 626 Caucasian subjects without type 2 diabetes in quantitative trait analyses. 18 This was in contrast to the study by Zhang et al who did not find any association with fasting glucose or insulin levels in 630 healthy individuals.…”

NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus

“…6,7 However, in the present study no mutation of the NAMPT -948G ⁄ T polymorphism was detected in Chinese Han T2DM patients and healthy controls. These apparent discrepancies imply that there is probably an ethnic difference in the distributive frequency of the NAMPT -948G ⁄ T polymorphism and that the NAMPT -948G ⁄ T polymorphism is possibly unrelated to Chinese T2DM.…”

Pharmacogenetics of Oral Antidiabetic Drugs: Potential Clinical Application

“…Thus, NAMPT may be involved in the repaglinide action. Despite contradictory results were reported about the correlation of NAMPT gene polymorphisms and T2DM susceptibility [34,35], our result showed that -948G>T and -3186C>T polymorphisms are not associated with T2DM susceptibility in Chinese population. However, -3186C>T polymorphism is PGC-1α G1182A rs2970847 GG/ Good drug efficacy [73] PGC-1α G1444A rs8192678 GG/ Good drug efficacy [73] Adiponectin T45G rs2241766 TT/ Good drug efficacy [67] Adiponectin C-11377G CC/ Good drug efficacy [67] UCP2 G-866A GG/ Good drug efficacy [76] TNF-α G-308A GG/ Poor drug efficacy [79] associated with plasma levels of postprandial insulin secretion (PINS) and cholesterol (CHO) in Chinese T2DM patients with repaglinide monotherapy [22].We also found that frequencies of -3186C> T polymorphism in Chinese Han population were different from those in Caucasian populations, thus, different dosages of repaglinide may be used among different populations.…”

No Association between Visfatin (NAMPT) Gene Variants and Metabolic Traits in the Newfoundland Population

“…16 A number of other studies have also found no significant differences in allele, genotype, or haplotype frequencies between type 2 diabetes patients and healthy controls. 18,20,23,31 Interestingly, the study by Bottcher et al did observe a marginally significant association between variation in NAMPT and fasting plasma insulin levels as well as 2-h plasma glucose in 626 Caucasian subjects without type 2 diabetes in quantitative trait analyses. 18 This was in contrast to the study by Zhang et al who did not find any association with fasting glucose or insulin levels in 630 healthy individuals.…”