Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA

Association of gene polymorphism and serum levels of IL-12p40 with the susceptibility to non-Hodgkin’s lymphoma in Iraq

“…However, several analyses indicated that the C allele could lead to a decrease in the expression of IL-12p40, which consequently results in a lack of IL-12 protein. 22,32,33 On the other hand, the results of this study are inconsistent with a previous study, 34 where the A allele was found but not C to be associated with different cancers including the NHL and in TB infected patients, 35 that resulted in lower plasma levels of IL-12 in normal control rather than in TB infected patients. Thus, it is expected there will be an increase of IL-12 associated CC genotype resulting in robust cell-mediated immune response, as with the current result that revealed a strong relationship C allele with high levels of IL-12 which was more prevalent in NHLs patients than in healthy controls.…”

Association of gene polymorphism and serum levels of IL-12p40 with the susceptibility to non-Hodgkin’s lymphoma in Iraq

“…However, several analyses indicated that the C allele could lead to a decrease in the expression of IL-12p40, which consequently results in a lack of IL-12 protein. 22,32,33 On the other hand, the results of this study are inconsistent with a previous study, 34 where the A allele was found but not C to be associated with different cancers including the NHL and in TB infected patients, 35 that resulted in lower plasma levels of IL-12 in normal control rather than in TB infected patients. Thus, it is expected there will be an increase of IL-12 associated CC genotype resulting in robust cell-mediated immune response, as with the current result that revealed a strong relationship C allele with high levels of IL-12 which was more prevalent in NHLs patients than in healthy controls.…”

Aberrant expression of p-STAT3 in peripheral blood CD4+ and CD8+ T cells related to hepatocellular carcinoma development

“…We observed that the IFN-γ level is decreased and the IL-4 level is increased in the serum of HCC patients compared to healthy controls, in agreement with a previous study (36). Cytokine profiles indicating a deregulation of both Th1-and Th2-type cells have been previously associated with the development of HCC (18). Th1 cytokines (IFN-γ and IL-2) are related to cell-mediated immune responses in HCC (19).…”

Host genetic factors associated with hepatitis B virus infection and progression to chronic disease: A systematic review and Meta analysis

“…In our study, 12 eligible studies involved IL-10-1082A/G and IL-10-592C/A polymorphisms (Dondeti, El-maadawy, & Talaat, 2016, Gao et al, 2016,Gusatti et al, 2016, Yao et al, 2015, Manjita et al, 2014, Sofian et al, 2013Ge et al, 2009, Baghi, Alavian, Mehrnoush, & Salimi, 2015, Q. Gao et al, 2017) Sofian et al, 2013, 8 eligible studies involved INF-γ +874 (Heidari et al, 2016, Yao et al, 2015, Migita et al, 2005, Ognjanovic, Yuan, Chaptman, Fan, & Yu, 2009, 9 studies involved TNF-α (Panigrahi et al, 2014, Gusatti et al, 2016, Panigrahi et al, 2014, Migita et al, 2005, Q. Gao et al, 2017, Ognjanovic et al, 2009, Kim et al, 2018, Fletcher et al, 2011 and 5 studies involved VDR (Falleti et al, 2010,Suneetha et al, 2006, Peng et al, 2014, Elmer, Tuncbilek, Aydin, & Hizel, 2013, X. Yao et al, 2013. The numbers of quality scores for each study for each study were summarized in Table 1.…”

Association of gene polymorphism and serum levels of IL-12p40 with the susceptibility to non-Hodgkin’s lymphoma in Iraq

“…However, several analyses indicated that the C allele could lead to a decrease in the expression of IL-12p40, which consequently results in a lack of IL-12 protein. 22,32,33 On the other hand, the results of this study are inconsistent with a previous study, 34 where the A allele was found but not C to be associated with different cancers including the NHL and in TB infected patients, 35 that resulted in lower plasma levels of IL-12 in normal control rather than in TB infected patients. Thus, it is expected there will be an increase of IL-12 associated CC genotype resulting in robust cell-mediated immune response, as with the current result that revealed a strong relationship C allele with high levels of IL-12 which was more prevalent in NHLs patients than in healthy controls.…”

Aberrant expression of p-STAT3 in peripheral blood CD4+ and CD8+ T cells related to hepatocellular carcinoma development

“…We observed that the IFN-γ level is decreased and the IL-4 level is increased in the serum of HCC patients compared to healthy controls, in agreement with a previous study (36). Cytokine profiles indicating a deregulation of both Th1-and Th2-type cells have been previously associated with the development of HCC (18). Th1 cytokines (IFN-γ and IL-2) are related to cell-mediated immune responses in HCC (19).…”

Host genetic factors associated with hepatitis B virus infection and progression to chronic disease: A systematic review and Meta analysis

“…In our study, 12 eligible studies involved IL-10-1082A/G and IL-10-592C/A polymorphisms (Dondeti, El-maadawy, & Talaat, 2016, Gao et al, 2016,Gusatti et al, 2016, Yao et al, 2015, Manjita et al, 2014, Sofian et al, 2013Ge et al, 2009, Baghi, Alavian, Mehrnoush, & Salimi, 2015, Q. Gao et al, 2017) Sofian et al, 2013, 8 eligible studies involved INF-γ +874 (Heidari et al, 2016, Yao et al, 2015, Migita et al, 2005, Ognjanovic, Yuan, Chaptman, Fan, & Yu, 2009, 9 studies involved TNF-α (Panigrahi et al, 2014, Gusatti et al, 2016, Panigrahi et al, 2014, Migita et al, 2005, Q. Gao et al, 2017, Ognjanovic et al, 2009, Kim et al, 2018, Fletcher et al, 2011 and 5 studies involved VDR (Falleti et al, 2010,Suneetha et al, 2006, Peng et al, 2014, Elmer, Tuncbilek, Aydin, & Hizel, 2013, X. Yao et al, 2013. The numbers of quality scores for each study for each study were summarized in Table 1.…”

Association of gene polymorphism and serum levels of IL-12p40 with the susceptibility to non-Hodgkin’s lymphoma in Iraq

“…However, several analyses indicated that the C allele could lead to a decrease in the expression of IL-12p40, which consequently results in a lack of IL-12 protein. 22,32,33 On the other hand, the results of this study are inconsistent with a previous study, 34 where the A allele was found but not C to be associated with different cancers including the NHL and in TB infected patients, 35 that resulted in lower plasma levels of IL-12 in normal control rather than in TB infected patients. Thus, it is expected there will be an increase of IL-12 associated CC genotype resulting in robust cell-mediated immune response, as with the current result that revealed a strong relationship C allele with high levels of IL-12 which was more prevalent in NHLs patients than in healthy controls.…”

Aberrant expression of p-STAT3 in peripheral blood CD4+ and CD8+ T cells related to hepatocellular carcinoma development

“…We observed that the IFN-γ level is decreased and the IL-4 level is increased in the serum of HCC patients compared to healthy controls, in agreement with a previous study (36). Cytokine profiles indicating a deregulation of both Th1-and Th2-type cells have been previously associated with the development of HCC (18). Th1 cytokines (IFN-γ and IL-2) are related to cell-mediated immune responses in HCC (19).…”

Host genetic factors associated with hepatitis B virus infection and progression to chronic disease: A systematic review and Meta analysis

“…In our study, 12 eligible studies involved IL-10-1082A/G and IL-10-592C/A polymorphisms (Dondeti, El-maadawy, & Talaat, 2016, Gao et al, 2016,Gusatti et al, 2016, Yao et al, 2015, Manjita et al, 2014, Sofian et al, 2013Ge et al, 2009, Baghi, Alavian, Mehrnoush, & Salimi, 2015, Q. Gao et al, 2017) Sofian et al, 2013, 8 eligible studies involved INF-γ +874 (Heidari et al, 2016, Yao et al, 2015, Migita et al, 2005, Ognjanovic, Yuan, Chaptman, Fan, & Yu, 2009, 9 studies involved TNF-α (Panigrahi et al, 2014, Gusatti et al, 2016, Panigrahi et al, 2014, Migita et al, 2005, Q. Gao et al, 2017, Ognjanovic et al, 2009, Kim et al, 2018, Fletcher et al, 2011 and 5 studies involved VDR (Falleti et al, 2010,Suneetha et al, 2006, Peng et al, 2014, Elmer, Tuncbilek, Aydin, & Hizel, 2013, X. Yao et al, 2013. The numbers of quality scores for each study for each study were summarized in Table 1.…”