A Case Report of a Patient with Bronchiectasis Managed with <italic>Sikyungbanha-tang</italic>

Abstract

This case reports the management of a patient with bronchiectasis treated with Sikyungbanha-tang, an herbal extract covered by national health insurance. Methods: Twice a year, the patient was treated for a 30-day period with the herbal extract Sikyungbanha-tang. History-taking and a chest X-ray (CXR) were used to evaluate the effects. Results: Following treatment with herbal medicine, the patient's complaints of symptoms decreased, and improvement was shown on CXR. Conclusions: Sikyungbanha-tang in herbal extract form in insured herbal extracts has effects on the management of bronchiectasis patients.

Sikyungbanha‐Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3

“…Consistent with the results in Figure 3(b), SKBHT significantly suppressed the mRNA expression of those cytokine genes in the lung tissue (Figure 3(c)). To further confirm the effect of SKBHT on neutrophils, we measured the myeloperoxidase (MPO) activity that is mainly attributed to neutrophils [1,26]. As shown in Figure 3(d), SKBHT significantly suppressed MPO activity (4 th column), which was induced by LPS treatment (3 rd column).…”

“…SKBHT comprises ten different medicinal herbs [1], and some of the herbal constituents of SKBHT exhibit anti-inflammatory activity. For instance, Bupleuri Radix has been used to treat various inflammatory diseases, and its major chemical constituents saikosaponins are known to suppress inflammation [34].…”

“…Sikyungbanha-Tang (SKBHT) is a Chinese traditional herbal remedy popularly used in Korea as a curative for patients who suffer from inflammatory, respiratory symptoms, including cough, sputum, and fever [1]. Recently, the Korean National Health Insurance System enlisted the prescription of SKBHT as an insurance-covered therapeutics for patients who suffer from inflammatory diseases [2].…”

“…Despite the insurance system recognizing the effectiveness of SKBHT, the experimental or clinical evidence for the anti-inflammatory activity of SKBHT is limited; how SKBHT exerts this effect remains less understood. ere is a report showing that SKBHT is effective in pneumonia patients and a bronchiectasis patient [1]. In mouse peritoneal macrophages, SKBHT was shown to suppress the production of nitric oxide and proinflammatory cytokines induced by bacterial lipopolysaccharides (LPS) [3].…”

Sikyungbanha‐Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3

“…Consistent with the results in Figure 3(b), SKBHT significantly suppressed the mRNA expression of those cytokine genes in the lung tissue (Figure 3(c)). To further confirm the effect of SKBHT on neutrophils, we measured the myeloperoxidase (MPO) activity that is mainly attributed to neutrophils [1,26]. As shown in Figure 3(d), SKBHT significantly suppressed MPO activity (4 th column), which was induced by LPS treatment (3 rd column).…”

“…SKBHT comprises ten different medicinal herbs [1], and some of the herbal constituents of SKBHT exhibit anti-inflammatory activity. For instance, Bupleuri Radix has been used to treat various inflammatory diseases, and its major chemical constituents saikosaponins are known to suppress inflammation [34].…”

“…Sikyungbanha-Tang (SKBHT) is a Chinese traditional herbal remedy popularly used in Korea as a curative for patients who suffer from inflammatory, respiratory symptoms, including cough, sputum, and fever [1]. Recently, the Korean National Health Insurance System enlisted the prescription of SKBHT as an insurance-covered therapeutics for patients who suffer from inflammatory diseases [2].…”

“…Despite the insurance system recognizing the effectiveness of SKBHT, the experimental or clinical evidence for the anti-inflammatory activity of SKBHT is limited; how SKBHT exerts this effect remains less understood. ere is a report showing that SKBHT is effective in pneumonia patients and a bronchiectasis patient [1]. In mouse peritoneal macrophages, SKBHT was shown to suppress the production of nitric oxide and proinflammatory cytokines induced by bacterial lipopolysaccharides (LPS) [3].…”

Sikyungbanha‐Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3

“…Consistent with the results in Figure 3(b), SKBHT significantly suppressed the mRNA expression of those cytokine genes in the lung tissue (Figure 3(c)). To further confirm the effect of SKBHT on neutrophils, we measured the myeloperoxidase (MPO) activity that is mainly attributed to neutrophils [1,26]. As shown in Figure 3(d), SKBHT significantly suppressed MPO activity (4 th column), which was induced by LPS treatment (3 rd column).…”

“…SKBHT comprises ten different medicinal herbs [1], and some of the herbal constituents of SKBHT exhibit anti-inflammatory activity. For instance, Bupleuri Radix has been used to treat various inflammatory diseases, and its major chemical constituents saikosaponins are known to suppress inflammation [34].…”

“…Sikyungbanha-Tang (SKBHT) is a Chinese traditional herbal remedy popularly used in Korea as a curative for patients who suffer from inflammatory, respiratory symptoms, including cough, sputum, and fever [1]. Recently, the Korean National Health Insurance System enlisted the prescription of SKBHT as an insurance-covered therapeutics for patients who suffer from inflammatory diseases [2].…”

“…Despite the insurance system recognizing the effectiveness of SKBHT, the experimental or clinical evidence for the anti-inflammatory activity of SKBHT is limited; how SKBHT exerts this effect remains less understood. ere is a report showing that SKBHT is effective in pneumonia patients and a bronchiectasis patient [1]. In mouse peritoneal macrophages, SKBHT was shown to suppress the production of nitric oxide and proinflammatory cytokines induced by bacterial lipopolysaccharides (LPS) [3].…”

Sikyungbanha‐Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3

“…Consistent with the results in Figure 3(b), SKBHT significantly suppressed the mRNA expression of those cytokine genes in the lung tissue (Figure 3(c)). To further confirm the effect of SKBHT on neutrophils, we measured the myeloperoxidase (MPO) activity that is mainly attributed to neutrophils [1,26]. As shown in Figure 3(d), SKBHT significantly suppressed MPO activity (4 th column), which was induced by LPS treatment (3 rd column).…”

“…SKBHT comprises ten different medicinal herbs [1], and some of the herbal constituents of SKBHT exhibit anti-inflammatory activity. For instance, Bupleuri Radix has been used to treat various inflammatory diseases, and its major chemical constituents saikosaponins are known to suppress inflammation [34].…”

“…Sikyungbanha-Tang (SKBHT) is a Chinese traditional herbal remedy popularly used in Korea as a curative for patients who suffer from inflammatory, respiratory symptoms, including cough, sputum, and fever [1]. Recently, the Korean National Health Insurance System enlisted the prescription of SKBHT as an insurance-covered therapeutics for patients who suffer from inflammatory diseases [2].…”

“…Despite the insurance system recognizing the effectiveness of SKBHT, the experimental or clinical evidence for the anti-inflammatory activity of SKBHT is limited; how SKBHT exerts this effect remains less understood. ere is a report showing that SKBHT is effective in pneumonia patients and a bronchiectasis patient [1]. In mouse peritoneal macrophages, SKBHT was shown to suppress the production of nitric oxide and proinflammatory cytokines induced by bacterial lipopolysaccharides (LPS) [3].…”