2015
DOI: 10.1097/meg.0000000000000463
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: AimTo evaluate the main platelet volume (MPV) as a severity marker in patients with primary biliary cirrhosis (PBC).Materials and methodsThirty-nine patients with biopsy-proven and as yet untreated PBC followed between January 2008 and January 2015 were included in this study. Liver biopsies were categorized as early stage (stage 1 and 2 according to Scheuer’s histological stage) and late stage (Scheuer’s stage 3 and 4). As part of the routine evaluation, all PBC patients had their full blood count and biochem… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

2
12
1

Year Published

2016
2016
2021
2021

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 20 publications
(15 citation statements)
references
References 27 publications
2
12
1
Order By: Relevance
“…Further, studies investigating the relationship between biochemical markers and histological stages of fibrosis are limited in PBC. Recently, Tahtaci et al 27 found that increased MPV is related to the histologic severity of PBC, but their sample size of 39 patients was small. Hence, the need to identify a noninvasive diagnostic marker that is indicative of the histological severity observed in PBC in a large population is urgent.…”
Section: Discussionmentioning
confidence: 99%
“…Further, studies investigating the relationship between biochemical markers and histological stages of fibrosis are limited in PBC. Recently, Tahtaci et al 27 found that increased MPV is related to the histologic severity of PBC, but their sample size of 39 patients was small. Hence, the need to identify a noninvasive diagnostic marker that is indicative of the histological severity observed in PBC in a large population is urgent.…”
Section: Discussionmentioning
confidence: 99%
“…In the last decade, several studies have been carried out to evaluate liver fibrosis and noninvasive methods in PBC. [ 8 , 9 , 12 , 13 ] To our knowledge, this study is the first to evaluate noninvasive test to predict histological severity of PBC with spleen diameters. In this study, we assessed the diagnostic performance of five noninvasive parameters for the histological severity of PBC.…”
Section: Discussionmentioning
confidence: 99%
“…Most studies and prognostic scores report on only total bilirubin, although a key disease‐related component of total bilirubin is direct or conjugated bilirubin 6‐7,18‐20 . Tahtaci et al evaluated various haematological and biochemical parameters in patients with advanced or early‐stage PBC and found that, of total and direct bilirubin, only direct bilirubin level was significantly higher in patients with late‐stage disease 21 . Although fractionation of total bilirubin is not a routine clinical laboratory assessment at this time, the American College of Gastroenterology's clinical guidelines for the evaluation of abnormal liver chemistries recommends that total serum bilirubin levels be separated into direct and indirect fractions 22 .…”
Section: Introductionmentioning
confidence: 99%