This study aims to determine the toxic effect for different concentrations of supercyren pesticide on some physiological and histological features of the sixty male mice by oral administration. The experimental mice took oral administration of 5mg and 10mg/Kg every day to every mice for two weeks in group 2 and 3 respectively and for four weeks for group 5 and 6 respectively. After 2 or 4 weeks AST, ALT and ALP enzymes, urea , creatinine and testosterone hormone were estimated. The following organs were taken for histological studies (Liver, Kidney, testes). The results of this physiological study showed that the oral administration of supercyren pesticide affect these organs (Kidney, liver, testes). Then histological changes in kidney, liver and testes proved the physiological effect. On the other hand, the high concentration of the pesticide had a significant impact on users as well as the greater duration effect was greater physiological and histologically.
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