Chemistry and Biological Activity of Ramalina Lichenized Fungi

Moreira, Antônio Sérgio Nascimento; Braz-Filho, Raimundo; Mussi‐Dias, Vicente; Vieira, Ivo José Curcino

doi:10.3390/molecules20058952

Cited by 42 publications

(40 citation statements)

References 143 publications

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“…Herein, they likely come from hydrolysis of depsides and/or depsidones, a phenomenon that can occur during our extraction process. [40] As reviewed by Moreira et al, [37] the Ramalina genus is characterized by high content of usnic acid as well as depsides and depsidones. Our results showed that R. fastigiata and R. farinacea from Algeria were constituted of similar compounds.…”

Section: Discussionmentioning

confidence: 96%

“…Salazinic acid (compound 16, t R 6.25) already described in R. siliquosa var. crassa [36] was found at m/z 387.0347 [37] exhibits a typical fragmentation pattern as depicted in Figure 3. Indeed, the following ions can be observed in its MS/MS spectra at m/z 269.0446 ([M À H À CO 2 ] À ), 241.0491 ([M À H À CO À CO 2 ] À ), and 225.0544 ([M À H À 2CO 2 ] À ).…”

Section: Depsidonesmentioning

confidence: 99%

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UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

Rafika

Ahmed

Burger

et al. 2018

Chemistry & Biodiversity

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Lichens are complex symbiotic organisms able to produce a vast array of compounds. The Algerian lichen diversity has only prompted little interest even given the 1085 species listed. Herein, the chemodiversity of four Algerian lichens including Cladonia rangiformis, Ramalina farinaceae, R. fastigiata, and Roccella phycopsis was investigated. A dereplication strategy, using ultra high performance liquid chromatography-high resolution-electrospray ionization-mass spectrometry (UHPLC-HRMS/MS), was carried out for a comprehensive characterization of their substances including phenolics, depsides, depsidones, depsones, dibenzofurans, and aliphatic acids. Some known compounds were identified for the first time in some species. Additionally, the lichenic extracts were evaluated for their antifungal and antimicrobial activities on human pathogenic strains (Candida albicans, C. glabrata, Aspergillus fumigatus, Staphylococcus aureus, and Escherichia coli). Cyclohexane extracts were found particularly active against human pathogenic fungi with MIC values ranging from 8 to 62.5 μg/mL, without cytotoxicity. This study highlights the therapeutic and prophylactic potential of lichenic extracts as antibacterial and antifungal agents.

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Section: Discussionmentioning

confidence: 96%

Section: Depsidonesmentioning

confidence: 99%

UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

Rafika

Ahmed

Burger

et al. 2018

Chemistry & Biodiversity

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“…A diversity of secondary metabolites were isolated, includes dibenzofuran derivatives like usnic acid, depsides, depsidones, fatty acids, sterols and monocyclic aromatic compounds. Moreover, the biological screening of this genus results in identification of antioxidant, anti-inflammatory, anticancer, antimicrobial activities 9 . The present study was performed to evaluate the in vitro anti-inflammatory and cytotoxicity properties of two mangrove associated lichens namely Dirinaria consimilis and Ramalina leiodea using standard procedures and protocols.…”

Section: Vinay Bharadwaj Tatipamula Et Almentioning

confidence: 99%

In vitro anti-inflammatory and cytotoxicity studies of two mangrove associated lichens, Dirinaria consimilis and Ramalina leiodea extracts

Tatipamula¹,

Vedula²

2018

Hygeia.J.D.Med.

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Plan: To evaluate the anti-inflammatory and cytotoxicity activity of different extracts from two different manglicolous lichens (Dirinaria consimilis and Ramalina leiodea). Preface: Inflammation is the origin of several deadly diseases like cancer, atherosclerosis, Alzheimer’s and rheumatoid arthritis. From decades, lichen extracts and its metabolites are well known in treating inflammation and cancer. Outcome: The outcome of protein denaturation method confirmed that the ethyl acetate and acetone extract of R. leiodea depicted better inhibitory profile against protein denaturation with IC50 values of 268 and 330 µg/mL Furthermore, the results of SRB assay showed that ethyl acetate and acetone extracts of both the lichens acts potently against MCF-7, DLD-1, HeLa and A549. Simultaneously, all the tested extracts depicted the low degree of specificity towards NHME, they are less toxic. Hence, further screening of these extracts may lead to the exploration of safe and potent anti-inflammatory and anticancer agents.

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“…The Ramalina genus has approximately 246 species distributed around the world, of which in this review approximately 118 species with published chemical or biological activity studies of extracts or isolated compounds were cited. [2] This paper reports the isolation and structural determination of eight compounds from the chloroform extract of the lichen Ramalina peruviana Ach. (Ramalinaceae), collected at Cau Dat farm, Lam Dong province, Vietnam, and the α-glucosidase inhibitory activity of some isolated compounds.…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of chloroform extract from the lichen Ramalina peruviana Arch (Ramalinaceae)

Linh¹,

Danova

Truong

et al. 2020

Vietnam Journal of Chemistry

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From the chloroform extract of the lichen Ramalina peruviana Ach. (Ramalinaceae), collected at Cau Dat farm, Lam Dong province, Vietnam, eight organic compounds had been isolated: nonadecan-1-ol (1); nonadecenoic acid (2); (+)-(12R)-usnic acid (3); three monophenolic compounds-rhizonic acid (4), divarinolmonomethylether (5) and divaricatinic acid (6); and two depsides-decarboxy-2'-O-methyldivaricatic acid (7) and sekikaic acid (8). The chemical structure of these compounds was elucidated by spectroscopic analysis as well as high resolution ESI-MS analysis and comparison with those reported in the literature. Among these compounds, (1), (2), (4), (5) and (7) were the first time known in the Ramalina genus. Although compound (7) was detected in the lichen Neofuscelia depsidella by chromatographic comparisons with authentic material that was synthesized by condensation of the benzoic acid and 3-methoxyl-5propylphenol but it is isolated in the nature for the first time. The results of determining the α-glucosidase inhibitory activity of four isolated compounds show that the α-glucosidase inhibitory effect of (8) was the best with IC50 values in 136.62 μg/mL (compared with the control acarbose IC50 93.63 μg/mL).

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Chemistry and Biological Activity of Ramalina Lichenized Fungi

Cited by 42 publications

References 143 publications

UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

UHPLC‐HRMS/MS Based Profiling of Algerian Lichens and Their Antimicrobial Activities

In vitro anti-inflammatory and cytotoxicity studies of two mangrove associated lichens, Dirinaria consimilis and Ramalina leiodea extracts

Chemical constituents of chloroform extract from the lichen Ramalina peruviana Arch (Ramalinaceae)

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