Assistant Professor; James Madison University

Martin, Carla D.

doi:10.5948/9781614441168.088

Cited by 5 publications

(12 citation statements)

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“…10 However, it has recently been reported that in wounds with a low risk of infection, neutrophils delayed wound healing and accelerated scar formation. 28,29 In the present study, the administration of rIL-17A promoted the neutrophil accumulation and impeded the wound healing.…”

Section: Discussionmentioning

confidence: 45%

IL‐17A promotes neutrophilic inflammation and disturbs acute wound healing in skin

Takagi

Kawakami

Emi

et al. 2016

Experimental Dermatology

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In the wound healing process, neutrophils are the first inflammatory cells to move to the wound tissues. They sterilize wounds by killing microbes, and they stimulate other immune cells to protect the host from infection. In contrast, neutrophil-derived proteases cause damage to host tissues, so neutrophils play dual opposite roles in wound healing. Interleukin-17A (IL-17A) is a proinflammatory cytokine that promotes the recruitment of these cells. The role of this cytokine in the wound healing process is not fully clarified. In the present study, therefore, we examined how defect in IL-17A production affected the wound healing in skin. IL-17A-knockout (KO) mice showed promoted wound closure, myofibroblast differentiation and collagen deposition and decreased the neutrophil accumulation compared with wild-type (WT) mice. In contrast, the administration of recombinant IL-17A led to delayed wound closure, low collagen deposition and accelerated neutrophilic accumulation. In addition, the treatment of IL-17A-administered mice with a neutrophil elastase inhibitor improved the wound repair to the same level as that of WT mice. These results indicated that IL-17A hampered the wound healing process and suggested that neutrophilic inflammation caused by IL-17A may be associated with impaired wound healing in skin.

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Section: Discussionmentioning

confidence: 45%

IL‐17A promotes neutrophilic inflammation and disturbs acute wound healing in skin

Takagi

Kawakami

Emi

et al. 2016

Experimental Dermatology

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“…View Content, View profiles of others, View own profile, Add Profile Image, Add Profile Text, View Blogs, View Discussion Forum, Contribute to Discussion Forum, Contribute to Blogs, Write Wall Comment, Friending, Plan Meals, Check Diet Compliance, Click on News Feed, Record Weight4 We also measured interaction levels using raw counts of actions for each feature and obtained similar results.…”

mentioning

confidence: 57%

“…In some arenas, e.g., e-commerce, where customer loyalty is important, retaining even small numbers of users reaps significant rewards [5]. Social technologies, like Yahoo Answers and Wikipedia, survive by retaining users and their contributions in order to supply services and information [4]. In domains, like health and the environment, where online interventions are becoming more popular, the benefits of retaining users goes beyond financial gains and vibrant networks, and directly impact on user attitude and behaviour.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with persistent participation in an online diet intervention

Freyne

Saunders

Brindal

et al. 2012

CHI '12 Extended Abstracts on Human Factors in Computing Systems

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In recent years, much work has been carried out in interface design and service quality in order to maximise user experience and sustain engagement. We are often unsure, however, what factors really influence user interactions with the technologies. Here we report on an ongoing examination of the relationships between user demographics, self reported attitudes, efficacy, and system feature, and participation on an online diet support site. Our findings indicate that not only the characteristics of the users themselves are associated with sustained engagement with a weight loss site, but also that usage of particular features on the site results in higher return rates. These findings support a push for designers to understand their users and features of their site, in order to maximise engagement with their target audiences.

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“…Powder X-ray diffraction was performed using a PANalytical XÕPert PRO diffractometer and Cu wavelength. Identification of the crystallographic phases in diffractograms was performed using the X powder program (J. D. Martin, 2004).…”

Section: Analysesmentioning

confidence: 99%

Growth of Self‐Assembling Tubular Structures of Magnesium Oxy/Hydroxide and Silicate Related With Seafloor Hydrothermal Systems Driven by Serpentinization

Sainz‐Díaz

Escamilla‐Roa

Cartwright

2018

Geochem Geophys Geosyst

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Tubular structures self‐assemble from precipitating magnesium salts under the chemical garden chemobrionic growth process. Two experimental procedures, the dissolution of magnesium salt pellets and the injection of magnesium salt solutions into silicate solutions, were explored to reproduce in the laboratory the geochemical conditions under which similar structures may form from mineral‐rich fluids at some seafloor hydrothermal vents driven by serpentinization. X‐ray diffraction and Raman microspectroscopy applied to the materials formed indicated the presence of layers of magnesium silicate and magnesium oxide/hydroxide. Quantum mechanical calculations based on density functional theory were performed on models of hydrated magnesium silicate surfaces and related minerals to explain the Raman spectroscopy results. We examine the precipitate morphology, chemical structure, and crystal or mineral structure in our experiments and how these change with the reaction conditions. This is a fascinating example in geochemistry of a self‐organizing nonequilibrium process that creates complex structures.

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