Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective

Jamadagni, Pallavi Shrirang; Pawar, Sharad; Jamadagni, Shrirang; Chougule, Shridhar; Gaidhani, Sudesh; Murthy, Subramanyam N.

doi:10.4103/phrev.phrev_31_16

Cited by 28 publications

(16 citation statements)

References 13 publications

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“…The liver, renal, and cerebral toxicity of Devil's weed and the cytotoxicity of bitter oleander, guava, and passion fruit leaf extracts consumed by patients in our study are well described . It was interesting to note that the liver biopsies of those consuming Malabar nut tree (or vasaka) extracts demonstrated autoimmune hepatitis‐like histologic features, probably because of the presence of quinazoline alkaloids, phytosteroids, chalcones, triterpenoids, and flavonoids with possible immunomodulatory properties .…”

Section: Discussionmentioning

confidence: 57%

A Single‐Center Experience on Outcomes of Complementary and Alternative Medicine Use Among Patients With Cirrhosis

Philips¹,

Paramaguru

Augustine³

et al. 2019

Hepatol Commun

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Drug‐induced liver injury (DILI) due to complementary and alternative medicine (CAM) use is on the rise throughout the world by patients looking for “safer” alternatives. However, data on acute‐on‐chronic liver failure (ACLF) due to CAM are lacking. In a large cohort of patients with cirrhosis, we retrospectively studied CAM‐related health‐seeking behavior and attempted to identify those who developed possible CAM‐DILI‐related ACLF. In this study, we examine the clinical, biochemical, and liver histopathologic characteristics of possible CAM‐DILI‐related ACLF, describe implicated CAM agents, and discuss predictors of patient outcomes. Out of 1,666 patients with cirrhosis, 68% used CAM at some point. A total of 35.7% (n = 30/84) patients presented with CAM‐related DILI leading to ACLF in the whole CAM‐DILI‐related decompensation cohort. The most common CAM was unlabeled polyherbal Ayurvedic formulations. Of possible patients with ACLF, 63% self‐medicated with CAM based on social media sharing. Mean age ± SD was 51.9 ± 9.9 years, 83% were male patients, median follow‐up duration was 173 (range, 14‐584) days, median Child‐Turcotte‐Pugh score was 13 (range, 10‐14), Model for End‐Stage Liver Disease‐sodium score was 30.1 ± 4.8, median chronic liver failure‐organ failure (CLIF‐C‐OF) score was 11 (range, 8‐14), and median CLIF‐C‐ACLF score was 98 (range, 87‐127). Portal‐based neutrophilic predominant mixed inflammation, hepatocyte ballooning, autoimmune‐like features, and severe cholestasis were seen on liver biopsy. Overall, 53% of patients died (median survival 194 days). Baseline overt hepatic encephalopathy and CLIF‐C‐OF score, total bilirubin, hyponatremia and leukocytosis, and grade of ACLF predicted 1‐, 3‐, 6‐ and 12‐month mortality, respectively. Conclusion : Possible CAM‐DILI‐related ACLF has a high mortality. Strict monitoring and identification of CAM use among people with cirrhosis and an integrative public health educational practice can help ameliorate this modifiable risk factor that potentiates heavy liver disease burden and resource use.

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Section: Discussionmentioning

confidence: 57%

A Single‐Center Experience on Outcomes of Complementary and Alternative Medicine Use Among Patients With Cirrhosis

Philips¹,

Paramaguru

Augustine³

et al. 2019

Hepatol Commun

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“…In addition, HABE blocked RANKL-induced osteoclastogenesis at noncytotoxic concentrations. A clinical pharmacology study reported that 70% of clinical symptoms were improved in the individuals given 4 g of H. antidysenterica stem bark extract/day [ 11 ]. Therefore, HABE may be a safe anticancer agent against OSCC growth and OSCC-mediated bone resorption.…”

Section: Discussionmentioning

confidence: 99%

“…Holarrhena antidysenterica L. (Apocynaceae), which is distributed throughout Sri Lanka and India up to an altitude of 3,500 ft, has been used as a folk remedy for treating various diseases, including diarrhea, stomach pain, and dysentery, in India [ 10 ]. Seed extract of H. antidysenterica has antidiabetic, antihyperglycemic, and antihyperlipidemic activities [ 11 ]. The methanol extract of H. antidysenterica leaves, which has a high level of total phenolic content, scavenges reactive oxygen species (ROS) that otherwise participate in every step of carcinogenesis by causing intrinsic oxidative stress [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Methanol Extract of Holarrhena antidysenterica Inhibits the Growth of Human Oral Squamous Cell Carcinoma Cells and Osteoclastogenesis of Bone Marrow Macrophages

Yoon

Park

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Oral squamous cell carcinoma (OSCC) frequently invades mandibular bone, and outcomes for treatment with surgical resection are typically poor, ultimately resulting in death. Holarrhena antidysenterica L. (Apocynaceae), distributed throughout Sri Lanka and India, has been used as a folk remedy to treat various diseases. Treatment with methanol extract of H. antidysenterica bark (HABE) inhibited cell viability and BrdU incorporation and induced apoptotic cell death in Ca9-22 gingival and HSC-3 tongue SCC cells. Flow cytometric analysis indicated that HABE treatment preferentially induces apoptotic cell death via increasing the sub-G1 peak in Ca9-22 cells and cell cycle arrest at the G1 phase in HSC-3 cells. HABE treatment in the presence of zVAD-fmk, a pan-caspase inhibitor, rescued cell viabilities in both OSCC cell lines. The ratio of Bax to Bcl-2 increased with reductions in the Bcl-2 protein expression, and the activation of caspase 3 and subsequent cleavage of PARP was detected in HABE-treated Ca9-22 and HSC-3 cells. Furthermore, HABE treatment at noncytotoxic concentrations inhibited osteoclast formation in RANKL-stimulated bone marrow macrophages. Taken together, HABE possesses the inhibitory activity on the growth of OSCC cells and antiosteoclastogenic activity. Therefore, HABE may be a promising alternative and complementary agent for preventing and treating OSCC.

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“…The aim of next regimen was to maintain remission, prevent relapse, eliminate probability of malignancy via antioxidant and antineoplastic remedies. Conessine, an alkaloid extracted from bark of Holarrhena antidysenterica gives protection against multiple stages of diarrhea [28]. Pal et al observed that the bark powder administered to patients with bleeding piles at a dose of 4 g twice a day for 2 weeks each showed signifi cant effi cacy [29], Plumbago zeylanica possess bactericidal activity [30] and also helps in normalizing gut fl ora [31].…”

Section: Endoscopy With Biopsymentioning

confidence: 99%

A case with rare manifestation of Cronkhite-Canada Syndrome with remission after treatment and literature review

Patel¹,

Mani²

2018

Glob J Medical Clin Case Rep

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Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective

Cited by 28 publications

References 13 publications

A Single‐Center Experience on Outcomes of Complementary and Alternative Medicine Use Among Patients With Cirrhosis

A Single‐Center Experience on Outcomes of Complementary and Alternative Medicine Use Among Patients With Cirrhosis

Methanol Extract of Holarrhena antidysenterica Inhibits the Growth of Human Oral Squamous Cell Carcinoma Cells and Osteoclastogenesis of Bone Marrow Macrophages

A case with rare manifestation of Cronkhite-Canada Syndrome with remission after treatment and literature review

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