A case with rare manifestation of Cronkhite-Canada Syndrome with remission after treatment and literature review

Patel, Dharmik; Mani, Tripathi Kaushalendra

doi:10.17352/2455-5282.000065

Glob J Medical Clin Case Rep

2018

DOI: 10.17352/2455-5282.000065

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A case with rare manifestation of Cronkhite-Canada Syndrome with remission after treatment and literature review

Dharmik Patel¹,

Tripathi Kaushalendra Mani²

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2022

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Cronkhite-Canada syndrome: First case report from Egypt and North Africa

Alzamzamy¹,

Aboubakr²,

Okasha³

et al. 2022

World J Gastrointest Endosc

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BACKGROUND Gastrointestinal (GI) polyposis is a rare condition in GI diseases. To date about 500 cases of Cronkhite-Canada syndrome (CCS) have been reported worldwide. CASE SUMMARY We report a 60-year-old female patient who presented with dyspepsia, abdominal pain, and weight loss of 1-year duration. Her physical examination showed alopecia and onychodystrophy. Upper endoscopy revealed diffuse markedly thickened gastric mucosa involving the whole stomach with thickened gastric rugae and numerous polypoidal lesions. Histopathological examination showed marked hyperplasia of the foveolar glands with inflammatory cell infiltration. Endoscopic ultrasound showed a significantly hypertrophic mucosa and muscularis mucosa, while the submucosa and the muscularis propria were spared, favouring its benign nature. Colonoscopy showed multiple sessile polyps scattered at different parts of the colon. Histopathological examination revealed tubular adenomatous polyps with low-grade dysplasia. Differential diagnoses included CCS, Menterier disease (MD), other polyposis syndromes, lymphoma, amyloidosis, and gastric malignancies. The presence of alopecia, nail dystrophy, GI polyposis, markedly thickened gastric mucosa and folds, abdominal pain, weight loss, and marked foveolar gland hyperplasia; all was in favour of CCS. Lymphoma was excluded due to sparing of the muscularis propria. The presence of colonic polyps and antral and duodenal infiltration, and the absence of hypoproteinaemia decreased the possibility for MD. CONCLUSION The patient was diagnosed as having CCS.

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Cronkhite-Canada syndrome: First case report from Egypt and North Africa

Alzamzamy¹,

Aboubakr²,

Okasha³

et al. 2022

World J Gastrointest Endosc

View full text Add to dashboard Cite

show abstract

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A case with rare manifestation of Cronkhite-Canada Syndrome with remission after treatment and literature review

Cited by 1 publication

References 30 publications

Cronkhite-Canada syndrome: First case report from Egypt and North Africa

Cronkhite-Canada syndrome: First case report from Egypt and North Africa

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