Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect

Markovitch, Daniella; Tyrrell, Rex M.; Thompson, Dylan

doi:10.1152/japplphysiol.00096.2008

Cited by 62 publications

(84 citation statements)

References 44 publications

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“…Hirose et al (35) stated that the activities that performed resistive eccentric cause a significant increase in serum IL-10. In addition, Markovitch et al (14) and Wilund (36) stated that by increasing physical fitness, concentrations of IL-10 increase; thus, IL-10 has a direct relationship with the fitness that is consistent with the results of the present study. In study of Kasapis and Thompson (37) indicated that some of the beneficial effects of physical activity increase the IL-10 by stimulating anti-inflammatory actions.…”

Section: Discussionsupporting

confidence: 92%

“…Several studies have shown the inverse relationship between fitness and the amount of lymphocytes and inflammatory markers such as IL-6 and C-reactive protein (CRP), whereas IL-10 has been shown to be positively correlated with fitness. Encouraging the obese individuals, especially children and teens who face with a critical period of their life, to participate in a regular and a desirable sports activity forces the researchers to encourage the people in sports as well as guarantee their health (13,14).…”

Section: Introductionmentioning

confidence: 99%

“…The CRP has been identified as a risk factor for cardiovascular disease (14). The risk of heart attack in people with the CRP concentration higher than 2.11 mg/L is three times higher than those who will not have levels higher than 55.0 g/L (15).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of an Eight-Week Rope Skipping Exercise Program on Interleukin-10 and C-Reactive Protein in Overweight and Obese Adolescents

Zakavi¹,

Bizhani

Hashemi

et al. 2015

Jentashapir J Health Res

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Background:The different effects of exercise on obesity in obese adolescents have not sufficiently been studied. Objectives: This study aimed to investigate the effect of an eight-week rope skipping exercise on interleukin-10 (IL-10) and C-reactive protein (CRP) in obese and overweight adolescents. Patients and Methods:In this semi-experimental study, using purposive convenience sampling 30 overweight and obese teens were randomly divided into two groups: the experimental (height 165.28 cm; weight 85.53 kg and age 13.73 years old) and control (height 164.54 cm; weight 83.02 kg and age 13.93 years old) groups. Then the experimental group performed the eight-week rope skipping exercise program while the control group did not receive any intervention and was only following up. Before and after the exercise, the variables including weight, fat percentage, body mass index (BMI) and the maximum oxygen consumption (Vo2max) in both groups were measured. To assess the amount of serum IL-10, CRP, 48 hours before and after the exercise, fasting blood samples were taken during the two-stage mode. The correlated t-test and the independent t-test were used to compare the intragroup and intergroup relationships, respectively. Results: There was no significant change in the serum levels of IL-10 (P > 0.05); however, the intragroup comparison in the experimental group showed a significant increase in serum levels of IL.10 (P < 0.05). Moreover, the variables of the weight, BMI, fat percentage, V02max and CRP were significantly changed (P < 0.05). Conclusions: A rope skipping protocol increases the anti-inflammatory index, reduces the risk of cardiovascular disease, and improves the body compounds and immune system of the obese and overweight teens.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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The Effect of an Eight-Week Rope Skipping Exercise Program on Interleukin-10 and C-Reactive Protein in Overweight and Obese Adolescents

Zakavi¹,

Bizhani

Hashemi

et al. 2015

Jentashapir J Health Res

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“…Com relação ao exercício de baixa intensidade houve uma pequena redução na concentração circulante da IL-6 imediatamente após o exercício, resposta esta, que contradiz prévios achados, que em geral apresentam pequenos incrementos ou nenhum efeito 12,33 do exercício sobre a IL-6.…”

Section: Discussionunclassified

Efeitos de diferentes intensidades de exercício sobre a concentração sérica de interleucinas

Neves

Tenório

Muniz

et al. 2014

Rev. bras. educ. fís. esporte

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ResumoO presente estudo teve como objetivo analisar os efeitos agudos e de curta duração de duas intensidades de exercício aeróbio sobre a concentração circulante de IL-6 e IL-10. Quinze homens jovens fi sicamente ativos (21,0 ± 1,9 anos) foram submetidos a duas sessões de exercício ("crossover"): alta intensidade de exercício (AIE)-(80% VO 2 pico), e baixa intensidade de exercício (BIE)-(40% VO 2 pico), com intervalo de sete dias ("Wash out"). Amostras de sangue foram coletadas em tubos com EDTA, antes do exercício (basal), imediatamente após o exercício (agudo) e após 2 h de recuperação passiva. As concentrações séricas de IL-6 e IL-10 foram determinadas com a utilização de kits comerciais de ELISA. Os resultados demonstraram elevação aguda da IL-6, em resposta ao AIE em relação ao BIE (p < 0,05), enquanto que a IL-10 apresentou maior redução sistêmica aguda para BIE em comparação a AIE (p < 0,05). Não houve diferença na variação das citocinas após 2 h do término do exercício. Conclui-se que ambas as sessões agudas de exercício são capazes de modular a concentração circulante destas citocinas, e que a magnitude das alterações são dependentes da intensidade do esforço. PALAVRAS-CHAVE: Exercício aeróbio; Infl amação; Citocinas; Homens jovens.Um estado de in amação crônico, caracterizado pelo aumento na concentração sistêmica de algumas citocinas e proteína de fase aguda com concomitante redução da contagem de neutró los e células "natural killer" (NK) 1-2 , é um fator chave para o desenvolvimento de algumas condições patológicas 3 , tais como a resistência à insulina 4-5 e aterosclerose 6 .Por estarem envolvidas em diversas funções como angiogênese, lipólise, controle do metabolismo da glicose e regulação de processos in amatórios, citocinas como a interleucina 10 (IL-10) e a interleucina 6 (IL-6) têm recebido especial atenção por parte de diversos grupos de pesquisa [7][8] . O balanço entre a concentração circulante de citocinas pró e antiin amatórias, é considerado, um importante meio de controle da in amação crônica, estando condicionada a regulação por parte de fatores gené-ticos (polimor smos) e ao estilo de vida 9 .Dentre os fatores modi cáveis, o exercício físico ocupa um lugar de destaque, pois oferece proteção contra algumas das principais causas de morte na vida adulta, incluindo doenças cardiovasculares, diabetes tipo 2, câncer de cólon e de mama 2,10 .O efeito crônico do exercício físico sobre os processos in amatórios é re exo do somatório de diversas ações antiin amatórias promovidas pelas sessões de exercícios (efeito agudo) 1 . Classicamente, acredita-se que em resposta ao esforço físico, ocorram incrementos na produção da IL-6, com consequente disparo de uma cascata antiin amatória, efetivada pela elevação nos níveis circulantes de IL-10, do receptor antagonista da interleucina -1 (IL-1ra) e do receptor solúvel do

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“…It is largely accepted that the expression of IL-6 after acute physical activity do not reach consistent concentrations with short durations or low-to-moderate intensity of training (153) and that routine physical activity determines a decrease of IL-6 levels (instead of IL-10 concentration that is shown to increase). On the other hand, many studies reported data that assess how also low-intensity programs of exercise, such as fast walking (16,27,154,155), could produce a consistent decrease in plasma markers of systemic inflammation although does not determine any enhance in circulating cytokines expression (156). These data allow us to hypothesize that other well-known mechanisms (direct and indirect modulation of the activity of immune cells, neuroendocrine changes induced by exercise, reduced fat mass, for example) could explain a great part of the anti-inflammatory effect of exercise.…”

Section: Conclusive Remarksmentioning

confidence: 99%

New insights about the putative role of myokines in the context of cardiac rehabilitation and secondary cardiovascular prevention

et al. 2017

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Exercise training prevents the onset and the development of many chronic diseases, acting as an effective tool both for primary and for secondary prevention. Various mechanisms that may be the effectors of these beneficial effects have been proposed during the past decades: some of these are well recognized, others less. Muscular myokines, released during and after muscular contraction, have been proposed as key mediators of the systemic effects of the exercise. Nevertheless the availability of an impressive amount of evidence regarding the systemic effects of muscle-derived factors, few studies have examined key issues: (I) if skeletal muscle cells themselves are the main source of cytokine during exercise; (II) if the release of myokines into the systemic circulation reach an adequate concentration to provide significant effects in tissues far from skeletal muscle; (III) what may be the role carried out by muscular cytokine regarding the well-known benefits induced by regular exercise, first of all the anti-inflammatory effect of exercise. Furthermore, a greater part of our knowledge regarding myokines derives from the muscle of healthy subjects. This knowledge may not necessarily be transferred per se to subjects with chronic diseases implicating a direct or indirect muscular dysfunction and/or a chronic state of inflammation with persistent immune-inflammatory activation (and therefore increased circulating levels of some cytokines): cachexia, sarcopenia due to multiple factors, disability caused by neurological damage, chronic congestive heart failure (CHF) or coronary artery disease (CAD). A key point of future studies is to ascertain how is modified the muscular release of myokines in different categories of unhealthy subjects, both at baseline and after rehabilitation. The purpose of this review is to discuss the main findings on the role of myokines as putative mediators of the therapeutic benefits obtained through regular exercise in the context of secondary cardiovascular prevention.

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Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect

Abstract: Markovitch D, Tyrrell RM, Thompson D. Acute moderateintensity exercise in middle-aged men has neither an anti-nor proinflammatory effect.

Cited by 62 publications

References 44 publications

The Effect of an Eight-Week Rope Skipping Exercise Program on Interleukin-10 and C-Reactive Protein in Overweight and Obese Adolescents

The Effect of an Eight-Week Rope Skipping Exercise Program on Interleukin-10 and C-Reactive Protein in Overweight and Obese Adolescents

Efeitos de diferentes intensidades de exercício sobre a concentração sérica de interleucinas

New insights about the putative role of myokines in the context of cardiac rehabilitation and secondary cardiovascular prevention

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