Deep brain stimulation is an effective and safe medical treatment for a variety of neurological and psychiatric disorders including Parkinson's disease, essential tremor, dystonia, and treatment resistant obsessive compulsive disorder. A closed loop deep brain stimulation (CLDBS) system automatically adjusts stimulation parameters by the brain response in real time. The CLDBS continues to evolve due to the advancement in the brain stimulation technologies. This paper provides a study on the existing systems developed for CLDBS. It highlights the issues associated with CLDBS systems including feedback signal recording and processing, stimulation parameters setting, control algorithm, wireless telemetry, size, and power consumption. The benefits and limitations of the existing CLDBS systems are also presented. Whilst robust clinical proof of the benefits of the technology remains to be achieved, it has the potential to offer several advantages over open loop DBS. The CLDBS can improve efficiency and efficacy of therapy, eliminate lengthy start-up period for programming and adjustment, provide a personalized treatment, and make parameters setting automatic and adaptive.

This paper presents design, implementation, and evaluation of a miniature rectenna for energy harvesting applications. The rectenna produces DC power from a distant microwave energy transmitter. The generated DC power is then utilized to operate a head-mountable deep brain stimulation device. The rectenna consists of a miniature three-layer planar inverted-F antenna and a Schottky-diode-based bridge rectifier. The antenna has a volume of π × 6 × 1.584 mm 3 , a resonance frequency of 915 MHz with a simulated bandwidth of 18 MHz (907-925 MHz), and a measured bandwidth of 18 MHz (910-928 MHz) at the return loss of −10 dB. A dielectric substrate of FR-4 of ε r = 4.5 and δ = 0.02 is used for simulation and fabrication of the antenna and the rectifier due to its low cost. An L-section impedance matching circuit is employed between the antenna and the rectifier to reduce the mismatch loss. The impedance matching circuit operates as a low-pass filter eliminating higher order harmonics. A deep brain stimulation device is successfully operated by the rectenna at a distance of 20 cm away from a microwave energy transmitter of power 26.77 dBm. The motivation of this paper includes creation of a deep brain stimulation device that operates indefinitely without a battery. From the application standpoint, the developed energy harvesting rectenna facilitates long-term deep brain stimulation of laboratory animals for preclinical research investigating neurological disorders. INDEX TERMSEnergy harvesting, rectenna, deep brain stimulation, miniature device.

Design of a rectangular spiral planar inverted-F antenna (PIFA) at 915 MHz for wireless power transmission applications is proposed. The antenna and rectifying circuitry form a rectenna, which can produce dc power from a distant radio frequency energy transmitter. The generated dc power is used to operate a low-power deep brain stimulation pulse generator. The proposed antenna has the dimensions of 10 mm \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\times\,$ \end{document}12.5 mm \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\times\,$ \end{document}1.5 mm and resonance frequency of 915 MHz with a measured bandwidth of 15 MHz at return loss of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}${-}{\rm 10}~{\rm dB}$ \end{document}. A dielectric substrate of FR-4 of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\varepsilon _{r}=4.8$ \end{document} and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$\delta=0.015$ \end{document} with thickness of 1.5 mm is used for both antenna and rectifier circuit simulation and fabrication because of its availability and low cost. An L-section impedance matching circuit is used between the PIFA and voltage doubler rectifier. The impedance matching circuit also works as a low-pass filter for elimination of higher order harmonics. Maximum dc voltage at the rectenna output is 7.5 V in free space and this rectenna can drive a deep brain stimulation pulse generator at a distance of 30 cm from a radio frequency energy transmitter, which transmits power of 26.77 dBm.

A new three phase multilevel inverter with reduced number of components count is proposed in this paper. This inverter is designed using a single DC source per phase to generate multiple level output voltage which makes it suitable for low and medium voltage applications, including ac-coupled renewables or energy storages. A generalized circuit configuration is shown in this paper following which the number of output voltage level can be increased as per expectation. Although, each element endures the voltage stress equivalent to the input DC voltage, the value of total standing voltage (TSV) is reduced by the utilization of minimized number of components with respect to the number of series connected capacitors. Further, staircase modulation scheme is used to generate the switching signals. Hence, the proposed inverter can be operated at low switching frequency with optimal output current harmonic distortion which decreases switching losses and suppresses power factor falling. In order to validate the theoretical explanations and practical performances of the proposed inverter, the hypothesis is simulated for 9, 13 and 39 output voltage level inverters for three phase with a line voltage total harmonic distortion (THD) of 6.06%, 4.16% and 2.10% respectively in MATLAB/Simulink and a 5-level single phase laboratory prototype is implemented in the laboratory. INDEX TERMS Pulse width modulation inverters, multilevel inverters, total harmonic distortion, total standing voltage, photovoltaic systems, energy storage.

Deep brain stimulation has emerged as an effective medical procedure that has therapeutic efficacy in a number of neuropsychiatric disorders. Preclinical research involving laboratory animals is being conducted to study the principles, mechanisms, and therapeutic effects of deep brain stimulation. A bottleneck is, however, the lack of deep brain stimulation devices that enable long term brain stimulation in freely moving laboratory animals. Most of the existing devices employ complex circuitry, and are thus bulky. These devices are usually connected to the electrode that is implanted into the animal brain using long fixed wires. In long term behavioral trials, however, laboratory animals often need to continuously receive brain stimulation for days without interruption, which is difficult with existing technology. This paper presents a low power and lightweight portable microdeep brain stimulation device for laboratory animals. Three different configurations of the device are presented as follows: 1) single piece head mountable; 2) single piece back mountable; and 3) two piece back mountable. The device can be easily carried by the animal during the course of a clinical trial, and that it can produce non-stop stimulation current pulses of desired characteristics for over 12 days on a single battery. It employs passive charge balancing to minimize undesirable effects on the target tissue. The results of bench, in-vitro, and in-vivo tests to evaluate the performance of the device are presented.

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Due to global warming and shortage of fossil fuels, the grid-connected solar photovoltaic (PV) system has gained significant popularity all over the world. The modular multilevel cascaded (MMC) inverter is the natural choice for step-up transformer and line filter less direct medium voltage grid integration of solar PV systems. However, power quality and loss are the important issues while connecting the PV system to the medium voltage grid through MMC inverter. Modulation technique is the key to maintain output power quality, e.g., total harmonic distortion (THD) and to ensure low switching and conduction losses. In this paper, an advanced modulation technique named “triangle saturated common mode pulse width modulation (TSCMPWM)” control is proposed for a 3-phase 5-level MMC inverter-based grid-tied PV system. Compared to traditional modulation techniques, the proposed TSCMPWM control offers the lowest voltage THD as well as lower inverter power losses. Performance of the proposed modulation technique is evaluated in MATLAB/Simulink environment and tested with a reduced scale prototype test platform. Both simulation and experimental results show the effectiveness of the proposed modulation technique.