進行/再発非小細胞肺癌における癌免疫療法治療効果と宿主免疫栄養状態との関連性の検討

Fukushima, Shoji; Kinoshita, Fumihiko; Takamori, S.; Fujishita, Takatoshi; Ito, Kensaku; Toyozawa, Ryo; Seto, T.; Okamoto, Tatsuro

doi:10.2468/jbes.73.150

Cited by 64 publications

(17 citation statements)

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Section: Discussionsupporting

confidence: 89%

“…Moreover, the comparison of AUC values revealed that the PNI had higher discriminative ability than did the NLR and PLR. Our results are supported by the results of other studies that have reported that the PNI is a more robust biomarker and exhibits higher internal and external validity in predicting survival when compared with other inflammation‐related prognostic indices, such as the NLR, PLR and CRP (Bruixola et al., 2018; Du et al., 2015; Shoji et al., 2019; Tokunaga et al., 2017). A partial explanation for these findings is that the PNI combines both nutritional status and systemic inflammatory response, thus possibly rendering it a superior prognostic indicator to other inflammation‐based indices, which reflect only the host's inflammatory components and may be strongly influenced by external factors such as intercurrent inflammation, infection and corticosteroid use.…”

Section: Discussionsupporting

confidence: 88%

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Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer

et al. 2021

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Objective To investigate whether prognostic nutritional index (PNI) predicts patient survival outcomes in oral cavity squamous cell carcinoma (OSCC). Materials and methods The data of a total of 360 patients subjected to primary surgery for OSCC were retrospectively analysed. Patients were categorised into high‐PNI (≥51.75) and low‐PNI (<51.75) groups based on the PNI cut‐off value attained from receiver operating characteristic analyses (p < .001), and the intergroup differences in clinicopathological features were determined. The Kaplan–Meier method and Cox proportional hazard model were employed to determine the survival prediction ability of the PNI, and a nomogram based on the PNI was established for individualised survival prediction. Results A low PNI was noted to exhibit a significant association with shorter overall survival (OS) and disease‐free survival (DFS) (both p < .001). Multivariate Cox analyses showed that a lower PNI independently indicated shorter OS and DFS (hazard ratio [HR] = 2.187; p = .001 and HR = 1.459; p = .023, respectively). The concordance index and calibration plots of the PNI‐based nomogram revealed the high discriminative ability for OS. Conclusions Preoperative PNI is a valuable biomarker for predicting OSCC prognosis, and the proposed PNI‐based nomogram can provide individualised prognostic prediction.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer

et al. 2021

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“…It was found that there has a significant difference between elevated PLR and NLR levels with shorter OS and PFS in patients with advanced NSCLC treated with nivolumab (46). Pretreatment PNI has also been found to be an independent predictive biomarker for NSCLC patients after treatment with immune checkpoint inhibitors and may help to identify which patients can obtain good therapeutic effect from immune checkpoint inhibitors (47) there is no similar study on PNETs, immunotherapy is gradually emerging in SCLC research. It was found that acetazolamide monoclonal antibody could improve OS and PFS of SCLC patients more effectively than chemotherapy alone (48).…”

Section: Discussionmentioning

confidence: 99%

Preoperative systemic immune-inflammation index and prognostic nutritional index predict prognosis of patients with pulmonary neuroendocrine tumors after surgical resection

He¹,

Guo²,

Song³

et al. 2020

Ann Transl Med

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Background: Pulmonary neuroendocrine tumors (PNETs) are a special subtype of lung cancer with treatment methods are limited and prognostic indicators are insufficient. The preoperative systemic immuneinflammation index (SII) and prognostic nutritional index (PNI) are effective tumor biomarkers that have important significance for the prognosis of many malignant tumors. However, there is no similar research on the predictive value of SII and PNI for operable PNETs. Our study aimed to clarify the predictive value of SII and PNI in PNETs patients after surgical resection.Methods: This study retrospectively analysed the relevant clinical data of PNETs patients who received surgical treatment from 2005 to 2015, which was obtained from patient's clinical records, blood test results recorded on admission before surgical treatment, and follow-up by hospital records.Results: A total of 381 PNETs patients were enrolled in this study. Preoperative PNI was associated with age (P=0.001), T stage (P=0.001), tumor length (P=0.002), drinking status (P=0.013) and smoking status (P=0.049), while SII was significantly associated with T stage (P=0.001), tumor length (P=0.001) and TNM stage (P=0.001). There was significant difference between high SII and low PNI and worse OS of PENTs (P=0.001 and P<0.001). SII (P=0.002), neutrophil/lymphocyte ratio (NLR) (P<0.001), platelet/lymphocyte ratio (PLR) (P=0.001), lymph node metastasis (P<0.001), operation time (P=0.034<0.05), treatment (P<0.001) and PNI (P=0.044<0.05) were independent prognostic factors for PNETs identified by multivariate Cox regression analysis.Conclusions: High SII and low PNI indicated poor prognosis of patients with PNETs. Both of SII and PNI can predict the prognosis of PNETs and stratify patients for better treatment.

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“…Another research compared the PNI before and after the operation and confirmed the effectiveness of preoperative PNI in the prognosis prediction of patients after anticancer drug therapy [26]. It can also be used as a biomarker to predict therapeutic efficacy, even in immune checkpoint inhibitor (ICI) monotherapy [27].…”

Section: Introductionmentioning

confidence: 85%

Prognostic Nutritional Index and Neutrophil/Lymphocyte Ratio Can Serve as Independent Predictors of the Prognosis of Hepatocellular Carcinoma Patients Receiving Targeted Therapy

Chen

Zhang

Chen

et al. 2022

Journal of Oncology

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Objective. The prognostic nutritional index (PNI) is an immunonutritional indicator, and the neutrophil/lymphocyte ratio (NLR) reflects the inflammatory status. This research intends to determine the implications of NLR and PNI in evaluating the outcome of hepatocellular carcinoma (HCC) patients undergoing targeted therapy (TT). Methods. We retrospectively analyzed 83 patients’ records with sorafenib treatment for advanced HCC in the Second Affiliated Hospital of Anhui Medical University. Patient records comprised general data and blood routines. The PNI and NLR values were calculated using the serum albumin levels (ALB), neutrophil (NEU) count, and lymphocyte (LY) count. The optimal thresholds of the PNI and NLR for predicting HCC patients’ outcomes were calculated by X-tile. Patients were further assigned to low- and high-groups of PNI and NLR according to their thresholds. By using the Cox proportional hazards regression models, univariate and multivariate analyses were conducted to identify risk factors influencing the patient's prognosis. Results. The participants were assigned to the corresponding low-PNI (≤42.9; n = 10) and high-PNI (>42.9; n = 73) groups, as well as low-NLR (≤2.4; n = 64) and high-NLR (>2.4; n = 19) groups based on the critical values of PNI (42.9) and NLR (2.4) obtained through the X-tile calculation. A higher overall survival (OS) rate was observed in the high-PNI group and low-NLR group, than in the low-PNI group and high-NLR group, respectively. The disease control rate showed no evident difference between the groups. The PNI and NLR were of high reliability in predicting the OS of patients. Cox multivariate analysis identified the independence of the PNI and NLR as prognostic factors for patients receiving TT for advanced HCC. Conclusions. The pretreatment PNI and NLR levels have great prognostic implications for advanced HCC patients receiving TT. A higher PNI and a lower NLR suggest a higher postoperative survival rate.

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進行/再発非小細胞肺癌における癌免疫療法治療効果と宿主免疫栄養状態との関連性の検討

Cited by 64 publications

References 0 publications

Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer

Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer

Preoperative systemic immune-inflammation index and prognostic nutritional index predict prognosis of patients with pulmonary neuroendocrine tumors after surgical resection

Prognostic Nutritional Index and Neutrophil/Lymphocyte Ratio Can Serve as Independent Predictors of the Prognosis of Hepatocellular Carcinoma Patients Receiving Targeted Therapy

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