Клініко-Патогенетична Значущість Остеоасоційованих Мікроелементів При Хворобах Суглобів. Повідомлення І. Мікроелементоз У Крові

Syniachenko, О.V.; Гейко, И А; Сокрут, О.П.; Hapchenkova, D.S.; Perepada, H.V.

doi:10.22141/2224-1507.2.22.2016.75759

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Studying experimental osteoarthritis on mutant cell lines of chondrosarcoma SW1353 and model animals, it was found that increasing of zinc concentration in cell culture or adding it to the diet of rats reduces general oxidative stress, secretion of interleukin 1b, interleukin 13 and matrix metalloproteinase 13, thereby reducing the risk of osteoarthritis [26]. Studying the levels of microelementsin patients with rheumatic diseases, a decrease in zinc concentration was revealed only in osteoarthritis, magnesium concentration was reduced in osteoarthritis, rheumatoid arthritis, copper concentration was elevated in psoriatic arthritis [27]. According to the results of our research, a reduced concentration of zinc is associated with isolated JH.…”

Section: Discussionmentioning

confidence: 99%

The level of microelements and heterogeneity of joint hypermobility as an endophenotype of undifferentiated connective tissue dysplasia

et al. 2020

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Objective — The aim of the work was to study serum concentrations of magnesium, copper, zinc, phosphorus and calcium in individuals with undifferentiated connective tissue dysplasia (uCTD) and joint hypermobility (JH) in an isolated and combined state. Material and methods — the concentrations of magnesium, copper, zinc, phosphorus and calcium were measured by the direct colorimetric method in 55 people with joint hypermobility and in 34 – without hypermobility. Results — There were no significant differences between serum concentrations of microelementsin groups with and without JH. In patients with mild and severe uCTD significant decrease in serum magnesium concentrations was noted (U=2.12, p=0.034 and U=3.7, p=0.012). In patients with isolated JH significant serum zinc concentrationdecrease was revealed compared with the control group (U=3.12, p=0.022). Serum magnesium concentrations were reduced in all patients with uCTD and JH; in the groups with isolated dysplasia and combined pathology, the differences reached the level of statistical significance (U=2.78, p=0.024 and U=3.2, p=0.018). Conclusion — The study revealed significant associations of a decrease in serum magnesium concentrations with the development of uCTD in an isolated and combined with JH state and decrease in serum zinc concentrations with the development of isolated JH.

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Section: Discussionmentioning

confidence: 99%

The level of microelements and heterogeneity of joint hypermobility as an endophenotype of undifferentiated connective tissue dysplasia

et al. 2020

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Impact of the trace element status on the course of ankylosing spondylitis in the Orenburg Region patients

Якубова

Бугрова

Красиков

et al. 2019

Sovremennaâ revmatologiâ

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The role of trace elements (TEs) and their imbalance in the physiology of bone tissue and in the development of inflammatory diseases of the joints and spine has been discussed in recent years; however, there is no evidence for the TE status of patients with ankylosing spondylitis (AS) and its possible impact on the course of the disease.Objective: to investigate the impact of the TE status of patients with AS on the course, clinical manifestations, and activity of the disease.Patients and methods. Examinations were made in 58 patients (39 men and 19 women), residents of the Orenburg Region, with a reliable diagnosis of AS, the duration of which was 16 [11; 26] years. The patients’ mean age was 38 [31; 48] years. HLA-B27 antigen was detected in 91.4% of cases. In addition to the generally accepted examination, atomic absorption spectrophotometry was used to determine the hair levels of 9 TEs: Cu, Zn, Fe, Mn, Cr, Co, Ni, Pb, and Cd in all the patients.Results and discussion. The AS patients living in the Orenburg Region showed TE imbalance manifested by Cu and Zn deficiency and Ni, Cr, and Mn accumulation in the hair. Multidirectional correlations were found between the values of these TEs and the presence of extra-axial (peripheral arthritis, dactylitis) and extra-skeletal (uveitis) manifestations of AS, its activity, and severity of functional disorders.Conclusion. The preliminary results may suggest that the emerging imbalance of TEs can affect the course of AS, maintaining and increasing its activity.

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The effect of natural mineral bicarbonate sodium-calcium water «Tib-1» on the antioxidant status of rats with adjuvant rheumatoid arthritis

Skupnevskiy¹,

Batagova²,

Pukhaeva³

et al. 2022

Vopr. kurortol. fizioter. lech. fiz. kul't.

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Клініко-Патогенетична Значущість Остеоасоційованих Мікроелементів При Хворобах Суглобів. Повідомлення І. Мікроелементоз У Крові

Cited by 3 publications

References 12 publications

The level of microelements and heterogeneity of joint hypermobility as an endophenotype of undifferentiated connective tissue dysplasia

The level of microelements and heterogeneity of joint hypermobility as an endophenotype of undifferentiated connective tissue dysplasia

Impact of the trace element status on the course of ankylosing spondylitis in the Orenburg Region patients

The effect of natural mineral bicarbonate sodium-calcium water «Tib-1» on the antioxidant status of rats with adjuvant rheumatoid arthritis

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