β3‐Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche

Vafaei, Rana; Nassiri, Seyed Mahdi; Siavashi, Vahid

doi:10.1002/jcb.26143

Cited by 14 publications

(8 citation statements)

References 35 publications

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“…MSCs regulate the immuno-microenvironment by interacting with macrophages and regulating blood vessel formation by secreting angiogenic growth factors. This process involves interacting cells, including MSCs, macrophages, and vascular endothelial cells, as well as extracellular matrix molecules and cytokines, all of which constitute the MSC niche that is of great significance in regulating bone regeneration (Moore and Lemischka, 2006;Kuhn and Tuan, 2010;Vafaei et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications

Sun

Wan

Wang

et al. 2022

Front. Cell Dev. Biol.

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Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the most promising alternative to autologous bone grafting. However, one of the limiting factors of artificial bone grafts is the limited means of regulating stem cell differentiation during bone regeneration. As a weight-bearing organ, bone is in a continuous mechanical environment. External mechanical force, a type of biophysical stimulation, plays an essential role in bone regeneration. It is generally accepted that osteocytes are mechanosensitive cells in bone. However, recent studies have shown that mesenchymal stem cells (MSCs) can also respond to mechanical signals. This article reviews the mechanotransduction mechanisms of MSCs, the regulation of mechanical stimulation on microenvironments surrounding MSCs by modulating the immune response, angiogenesis and osteogenesis, and the application of mechanical stimulation of MSCs in bone regeneration. The review provides a deep and extensive understanding of mechanical stimulation mechanisms, and prospects feasible designs of biomaterials for bone regeneration and the potential clinical applications of mechanical stimulation.

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Section: Introductionmentioning

confidence: 99%

Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications

Sun

Wan

Wang

et al. 2022

Front. Cell Dev. Biol.

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“…IGF-1/IGF-2 bind to IGF-1R/IGF-2R on BMSCs and increase proliferation and self-renewal [83]. CXCL12 enhances BMSC colony forming capacity, which is promoted by activation of the b3-adrenergic neuron and followed by promotion of EPC colony forming potency [84].…”

Section: Bmsc/epc Nichementioning

confidence: 99%

Endogenous Stem Cells in Homeostasis and Aging

Lim

Son

2017

Tissue Eng Regen Med

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In almost all human tissues and organs, adult stem cells or tissue stem cells are present in a unique location, the so-called stem cell niche or its equivalent, continuously replenishing functional differentiated cells. Those endogenous stem cells can be expanded for cell therapeutics using ex vivo cell culture or recalled for tissue repair in situ through cell trafficking and homing. In the aging process, inefficiency in the endogenous stem cell-mediated healing mechanism can emerge from a variety of impairments that accumulate in the processes of stem cell self-renewal, function, differentiation capacity, and trafficking through cell autonomous intrinsic pathways (such as epigenetic alterations) or systemic extrinsic pathways. This review examines the homeostasis of endogenous stem cells, particularly bone marrow stem cells, and their dysregulation in disease and aging and discusses possible intervention strategies. Several systemic pro-aging and rejuvenating factors, recognized in heterochronic parabiosis or premature aging progeroid animal models, are reviewed as possible anti-aging pharmaceutical targets from the perspective of a healthy environment for endogenous stem cells. A variety of epigenetic modifications and chromosome architectures are reviewed as an intrinsic cellular pathway for aging and senescence. A gradual increase in inflammatory burden during aging is also reviewed. Finally, the tissue repair and anti-aging effects of Substance-P, a peptide stimulating stem cell trafficking from the bone marrow and modifying the inflammatory response, are discussed as a future anti-aging target.Keywords Hematopoietic stem cell Á Bone marrow stem cell Á Endothelial precursor cell Á Aging Á Rejuvenation & Youngsook Son

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“…Previous study showed that EPCs can be mobilized by SDF-1 cytokine and recruited to sites of neovascularization. 27,28 Furthermore, we found that increase in cEPCs was associated with increased circulating levels of VEGF, Ang1, and Ang2 cytokines that are considered as important activators of EPCs. 29,30 Previous studies showed that increases in angiogenic factors are associated with high proliferation and migration in EPCs.…”

Section: Discussionmentioning

confidence: 85%

“…Confirming this finding, we showed that SDF‐1 mRNA level increases in infants with ROP, which can induce EPC mobilization from the bone marrow to contribute into the growing network of blood vessels in the developing retina. Previous study showed that EPCs can be mobilized by SDF‐1 cytokine and recruited to sites of neovascularization …”

Section: Discussionmentioning

confidence: 99%

Increased circulation mobilization of endothelial progenitor cells in preterm infants with retinopathy of prematurity

Babaei

Alibabrdel

Asadian

et al. 2018

J of Cellular Biochemistry

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Retinopathy of prematurity (ROP) is a result of increased pathological neoangiogenesis of the retina in preterm infants. Cells responsible for the pathogenesis of ROP are unclear, but some evidence indicates that bone marrow derived cells are involved in this disorder. Endothelial progenitor cells (EPCs), play a role in angiogenesis in response to tissue ischemia or endothelial damage. In this study, the number of cEPCs in preterm infants with ROP was determined to identify whether the circulation mobilization of EPCs is associated with ROP. We evaluated 99 participants in this study: 22 preterm infants with ROP, 35 preterm infants without ROP, and 42 full-term infants. The release of EPCs in the circulation was first quantified. Thereafter, cEPCs were harvested and cultivated, then the biological features of these cells including migratory, proliferative, and tubulogenic activities were analyzed. The mRNA levels of some proangiogenic factors were also measured in preterm infants. Our results showed greater numbers of cEPCs in infants with ROP, which was associated with increased serum concentrations of angiogenic factors and with augmented proliferative, migratory, and tubulogenic activity of these cells. Western blotting showed increased protein levels of VEGF and HIF-α in cEPCs harvested from ROP infants. This study showed that ROP in preterm infants is associated with increased mobilization of EPCs into the circulation. Therefore, increased cEPCs along with elevated levels of angiogenic factors and tubulogenesis suggest that these cells may play a role in the development and progression of ROP.

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β3‐Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche

Cited by 14 publications

References 35 publications

Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications

Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications

Endogenous Stem Cells in Homeostasis and Aging

Increased circulation mobilization of endothelial progenitor cells in preterm infants with retinopathy of prematurity

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