β-Glucans in promoting health: Prevention against mutation and cancer

Mantovani, Mário Sérgio; Bellini, Marilanda Ferreira; Angeli, José Pedro Friedmann; Oliveira, Rodrigo Juliano; Silva, Ariane F.; Ribeiro, Lúcia Regina

doi:10.1016/j.mrrev.2007.07.002

Cited by 212 publications

(116 citation statements)

References 49 publications

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“…β-Glucan is a water-soluble fibre found in cereals, as well as in yeast, bacteria, algae and mushrooms (145) . The EPS β-glucan has been reported to have many health promoting properties, including immunomodulatory effects (146)(147)(148)(149) , lowering serum cholesterol levels (145,150) , antiosteoporotic (151) , antitumourigenic, anticytotoxic and antimutagenic effects (152,153) . Furthermore, oat β-glucan has also been associated with the ability to modulate satiety, thus controlling appetite (154,155) .…”

Section: Microbial Production Of Exopolysaccharidesmentioning

confidence: 99%

Gut microbiota, the pharmabiotics they produce and host health

et al. 2014

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A healthy gut microbiota plays many crucial functions in the host, being involved in the correct development and functioning of the immune system, assisting in the digestion of certain foods and in the production of health-beneficial bioactive metabolites or ‘pharmabiotics’. These include bioactive lipids (including SCFA and conjugated linoleic acid) antimicrobials and exopolysaccharides in addition to nutrients, including vitamins B and K. Alterations in the composition of the gut microbiota and reductions in microbial diversity are highlighted in many disease states, possibly rendering the host susceptible to infection and consequently negatively affecting innate immune function. Evidence is also emerging of microbially produced molecules with neuroactive functions that can have influences across the brain–gut axis. For example, γ-aminobutyric acid, serotonin, catecholamines and acetylcholine may modulate neural signalling within the enteric nervous system, when released in the intestinal lumen and consequently signal brain function and behaviour. Dietary supplementation with probiotics and prebiotics are the most widely used dietary adjuncts to modulate the gut microbiota. Furthermore, evidence is emerging of the interactions between administered microbes and dietary substrates, leading to the production of pharmabiotics, which may directly or indirectly positively influence human health.

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Section: Microbial Production Of Exopolysaccharidesmentioning

confidence: 99%

Gut microbiota, the pharmabiotics they produce and host health

et al. 2014

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“…They recognize b-glucans and mannoprotein as pathogen-associated molecular patterns (PAMPs) [31,45]. Significance of polysaccharides of cell wall in yeasts in stimulation of immunological response, antibacterial activity as well as probiotic one with respect to beneficial microflora of alimentary tract is emphasized [6,9,13,26,37,40,47,51,55]. Polymers of yeasts cell wall exhibit an ability to adsorb harmful chemical substances, for example, mycotoxins, they lower the level of cholesterol and triglycerides in blood, act in anti-mutagenic, anticancerous, antioxidative way, and protect against UV radiations [17,29,41,45,54].…”

Section: Introductionmentioning

confidence: 99%

Chemical composition of the cell wall of probiotic and brewer’s yeast in response to cultivation medium with glycerol as a carbon source

Bzducha-Wróbel

Kieliszek

Błażejak

2013

Eur Food Res Technol

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The structure of cell wall of yeasts (genus Saccharomyces) is one of the factors that determine their health-promoting properties connected to the presence of b-glucans and mannoprotein. The aim of the study was to determine the influence of glycerol as a carbon source on structural polymers of cell wall (b-glucan and mannoprotein) of probiotic yeasts Saccharomyces cerevisiae var. boulardii and brewer's yeasts S. cerevisiae R9. Significant increase of the percentage of polysaccharide content in the cell wall dry weight of S. cerevisiae R9 brewer's yeasts was noted (in the range of 10-20 %) after cultivation in medium containing glycerol at a concentration of 2-5 % and pH 4.0. The highest content of carbohydrates in probiotic yeasts' cell wall (58 %) was observed after cultivation in medium containing 3 % of glycerol and pH 5.0. The cell wall of probiotic yeasts was characterized by higher content of mannoprotein comparing with cell wall preparation of brewer's yeasts S. cerevisiae R9 composed mainly of b-glucans. After cultivation in mediums with 2 and 3 % of glycerol, the cell of brewer's yeasts contained the highest amount of b(1,3/1,6)-glucan in dry weight of the cell wall (about 36 %). Glycerol at a concentration of 3 and 5 % also intensified mannoprotein biosynthesis in cell wall of S. cerevisiae R9, approximating their content to those noted in the cells of probiotic yeasts (about 29 % (w/w) of dry weight of the cell wall) after cultivation in a medium of pH 5.0 containing 3 % of glycerol.

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“…In this context, β-glucans from mushrooms are considered as functional compounds because they appear to stimulate the immunomodulatory response, modulate humoral and cellular immunity, and thereby have a beneficial effect in fighting against infections. Moreover, these substances also exhibit hypocholesterolemic effects (Hetland et al 2008;Mantovani et al 2008) and are also promising candidates as anticoagulant agents (Chang et al 2006). Recently, they have been demonstrated to have anti-cytotoxic, antimutagenic and anti-tumorogenic properties, being promising candidates for pharmacological agents (Hetland et al 2008).…”

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confidence: 99%

Total, soluble, and insoluble dietary fibre contents of wild growing edible mushrooms

Nile¹,

Park²

2014

Czech J. Food Sci.

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Nile S.H., Park S.W. (2014): Total, soluble, and insoluble dietary fibre contents of wild growing edible mushrooms. Czech J. Food Sci., 32: 302-307.Mushrooms have been long valued as tasty and nutritional foods for human beings and assumed to contain beneficial fibres, so the objective of this study was to analyse 20 species of wild growing edible mushrooms for their total dietary fibre (TDF), insoluble dietary fibre (IDF), and soluble dietary fibre (SDF) contents. The TDF, IDF, and SDF contents ranged between 24-37, 12-21, and 2-4 g/100 g dry weight, respectively. The SDF as % of TDF was low in Phellinus florida (5.5%) and Phellinus rimosus (5.8%), and high in Sparassis crispa, lentinus squarrulosus, and lactarius sanguifluus (12.5%). Interestingly, the majority of the mushrooms had 10-11% of TDF as SDF. The TDF was high in Pleurotus djamor (37%) Cantharellus cibarius, Cantharellus clavatus, and Phellinus florida (36%), and low in lactarius sanguifluus (24%). Also, the majority of mushrooms had average 31.6% TDF and 2.85% SDF. These results indicate that mushrooms such as Sparassis crispa, lentinus squarrulosus, lentinus delicious, and Cantharellus clavatus are rich sources of TDF and SDF.

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β-Glucans in promoting health: Prevention against mutation and cancer

Cited by 212 publications

References 49 publications

Gut microbiota, the pharmabiotics they produce and host health

Gut microbiota, the pharmabiotics they produce and host health

Chemical composition of the cell wall of probiotic and brewer’s yeast in response to cultivation medium with glycerol as a carbon source

Total, soluble, and insoluble dietary fibre contents of wild growing edible mushrooms

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