β-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection

Shi, Shaohua; Yin, Lei; Shen, Xuehuai; Dai, Yun; Wang, Jieru; Yin, Daqiang; Zhang, Danjun; Pan, Xiaocheng

doi:10.3390/v14020237

Cited by 16 publications

(5 citation statements)

References 34 publications

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“…Namely, polysaccharides most often realize their antimicrobial potential through an improvement in immune functions, thereby affecting the overall defense ability of the organism. This was demonstrated, for example, in a study conducted by Shi et al; β-glucans from C. versicolor exert antiviral properties on influenza in experimental in vivo systems, via an increase in the production of various cytokines [ 24 ]. No direct antimicrobial effects were demonstrated with C. versicolor polysaccharides, but a boost in the phagocytic activity of macrophages was clear, suggesting an indirect increase in defensive mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome

et al. 2023

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The present study aimed to examine the biological activity and cardioprotective potential of Trametes versicolor heteropolysaccharides (TVH) in a rat model of metabolic syndrome (MetS). This study included 40 Wistar rats divided into 5 groups: CTRL—healthy non-treated rats; MetS—non-treated rats; and H-TV, M-TV and L-TV-rats with MetS treated with either 300, 200 or 100 mg/kg TVH per os for 4 weeks. After finishing the treatment, we conducted an oral glucose tolerance test (OGTT), hemodynamic measurements and the animals were sacrificed, hearts isolated and subjected to the Langendorff technique. Blood samples were used for the determination of oxidative stress parameters, lipid status and insulin levels. We showed that α-amylase inhibition was not the mode of TVH antidiabetic action, while TVH showed a moderate inhibition of pathogenic microorganisms’ growth (MIC 8.00 mg·mL−1; MBC/MFC 16.00 mg·mL−1). H-TV and M-TV significantly reduced the level of prooxidants (O2−, H2O2, TBARS; p < 0.05), increased antioxidants activity (SOD, CAT, GSH; p < 0.05), reduced blood pressure (p < 0.05), improved glucose homeostasis in the OGTT test (p < 0.05), and ejection fraction (p < 0.05) and cardiac contractility (p < 0.05) compared to MetS (p < 0.05). Moreover, TVH treatment normalized the lipid status and decreased insulin levels compared to MetS rats (p < 0.05). The obtained results demonstrated that the TVH may be considered a useful agent for cardioprotection in MetS conditions.

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Section: Discussionmentioning

confidence: 99%

Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome

et al. 2023

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“…β-glucan is a recognized and effective inducer for trained immunity to protect the organism from viral, bacterial, and fungal pathogens [ 3 , 19 , 20 , 21 ], and its immunomodulatory effect lasts for several weeks. Training phenotype of macrophages derived from myeloid cells protected the host from the secondary infection and improved the recovery from chemotherapy-induced myeloablation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1

Wang,

Li,

Tian

et al. 2023

Viruses

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Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming. However, it is unclear whether β-glucan plays a role in antiviral infection. Therefore, this study investigated the role of trained immunity induced by Candida albicans and β-glucan in antiviral innate immunity. It showed that C. albicans and β-glucan promoted the expression of interferon-β (IFN-β) and interleukin-6 (IL-6) in mouse macrophages triggered by viral infection. In addition, β-glucan pretreatment attenuated the pathological damage induced by the virus in mouse lungs and promoted the expression of IFN-β. Mechanistically, β-glucan could promote the phosphorylation and ubiquitination of TANK Binding Kinase 1 (TBK1), a key protein of the innate immune pathway. These results suggest that β-glucan can promote innate antiviral immunity, and this bioactive material may be a potential therapeutic target for antiviral treatment.

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“…The main biological activities attributed to medicinal mushrooms are due to the β-glucans present in their wall and in some plants. These substances are antitumor, immunomodulatory, antimicrobial, contraceptive, anti-inflammatory, prebiotic, and antioxidant [73,74]. Supplemental β-glucans in poultry diet can enhance their innate defense by inducing intestinal colonization and invasion of internal organs by Salmonella [75].…”

Section: β-Glucansmentioning

confidence: 99%

Natural Products as an Alternative to Formaldehyde for Disinfection of Fertile Eggs in Commercial Hatcheries

Rebolledo¹,

Casillas²,

Tellez³

et al. 2023

Poultry Farming - New Perspectives and Applications

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Formaldehyde has been used in commercial hatcheries to cleanse eggs and prevent illness. However, formaldehyde’s health risks and customer demand for eco-friendly products have spurred interest in natural egg disinfection. Formaldehyde-free natural materials sterilize viable eggs in commercial hatcheries. Formaldehyde’s health and environmental dangers start the chapter. Modern hatcheries need safer and greener options. Natural egg disinfectants are next: plant-based extracts, oils, and acids. These natural chemicals’ mechanisms, bactericidal properties, potential commercial hatchery pros, and cons are evaluated. The chapter also examines commercial hatcheries’ natural disinfectant limits. Cost-effectiveness, efficacy against common diseases, application simplicity, and hatchery equipment compatibility are discussed. Regulations and uniform egg disinfection using natural agents are covered in the chapter. It emphasizes industry stakeholders, researchers, and regulators working together to promote natural alternatives. Finally, formaldehyde-free natural substances can disinfect viable eggs in industrial hatcheries. Studying natural product-based disinfection methods will increase their efficacy, safety, and feasibility. This book chapter concludes with natural alternatives to formaldehyde for cleaning viable eggs in industrial hatcheries.

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β-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection

Cited by 16 publications

References 34 publications

Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome

Characterization, In Vitro Biological Activity and In Vivo Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quél. Heteropolysaccharides in a Rat Model of Metabolic Syndrome

β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1

Natural Products as an Alternative to Formaldehyde for Disinfection of Fertile Eggs in Commercial Hatcheries

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