Abstract:Parkinson Disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathological changes in the olfactory pathway of transgenic (Tg) mice expressing the human A30P mutant alpha-synuclein (alpha-syn) (alpha-syn-Tg mice) at 6-7 and 12-14 months of age, representing early and late-stages of motor progression, respectively. alpha-Syn-Tg mice at late stages exhibited olfactory behavioral deficits, which correlated with severe al… Show more
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