α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice

Li, Dan; Liu, Qianyu; Lu, Xiuqiang; Li, Zhengqiu; Wang, Chunming; Leung, Chung‐Hang; Wang, Ying; Peng, Cheng; Lin, Ligen

doi:10.18632/aging.102512

Cited by 16 publications

(27 citation statements)

References 70 publications

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“…Our study showed that obese rats given G. mangostana rind had decreased mean retroperitoneal adipocyte size. This finding was similar to previous findings showing decreased retroperitoneal and epididymal adipocyte size in mice treated with α-mangostin (10–50 mg/kg/day for 5 days–12 weeks) [ 31 , 32 , 33 ]. This suggests that α-mangostin could ameliorate obesity by reducing the expansion of fat cells.…”

Section: Discussionsupporting

confidence: 92%

“…The expansion of adipocytes in obesity contributes to chronic low-grade local and systemic inflammation which cause physiological and metabolic abnormalities such as insulin resistance and endothelial dysfunction [ 29 , 30 ]. Further, reduction in adipocyte size was linked to the reduction of white adipose tissue pro-inflammatory cytokines [ 31 , 32 ]. Our study showed that obese rats given G. mangostana rind had decreased mean retroperitoneal adipocyte size.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that α-mangostin could ameliorate obesity by reducing the expansion of fat cells. α-Mangostin also reduced ageing-related adipose tissue inflammation by decreasing macrophage content, changing pro-inflammatory macrophage polarisation and reducing pro-inflammatory cytokines and chemokines concentration, specifically IL-1β, iNOS and TNF [ 32 ]. The reduced inflammation was partly due to the downregulation of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) pathways in adipose tissue [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats

et al. 2021

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The pulp of the purple mangosteen, Garcinia mangostana, is a popular tropical fruit but the rind containing xanthones such as α-mangostin together with procyanidins and anthocyanidins is usually discarded as waste. However, this rind has been used in South-East Asia for diarrhoea, dysentery, skin infections and wounds. As xanthones have reported anti-inflammatory and antioxidant responses, this study has determined the bioactive compounds and evaluated the effects of G. mangostana rind on physiological, metabolic, liver and cardiovascular parameters in rats with diet-induced metabolic syndrome. Rats fed a diet with increased simple sugars and saturated fats developed obesity, hypertension, increased left ventricular stiffness, dyslipidaemia and fatty liver. Administration of G. mangostana rind as 5% of the food to rats with diet-induced metabolic syndrome gave a dose of 168 mg/kg/day α-mangostin, 355 mg/kg/day procyanidins, 3.9 mg/kg/day anthocyanins and 11.8 mg/kg/day hydroxycitric acid for 8 weeks which reduced body weight and attenuated physiological and metabolic changes in rats including decreased abdominal fat deposition, decreased abdominal circumference and whole-body fat mass, improved liver structure and function and improved cardiovascular parameters such as systolic blood pressure, left ventricular stiffness and endothelial function. These responses were associated with decreased infiltration of inflammatory cells, decreased deposition of collagen in both heart and liver and decreased mean adipocyte size in retroperitoneal adipose tissues. We conclude that, in rats with diet-induced metabolic syndrome, chronic intake of G. mangostana rind decreased infiltration of inflammatory cells which decreased physiological, metabolic, liver and cardiovascular symptoms.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats

et al. 2021

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“…Western blot analysis was performed as described previously [ 23 , 24 ]. In brief, protein concentration of sample was determined by using the BCA (bicinchoninic acid) protein assay kit (Thermo Fisher, Waltham, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Pimarane Diterpenoids from the Seeds of Caesalpinia minax as PTP1B Inhibitors and Insulin Sensitizers

Zhang

et al. 2020

Molecules

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Protein-tyrosine phosphatase 1B (PTP1B) has been considered as a promising target for treating insulin resistance. In searching for naturally occurring PTB1B antagonists, two new pimarane diterpenoids, named 2α-hydroxy-7-oxo-pimara-8(9),15-diene (1) and 19-hydroxy-2α-acetoxy-7-oxo-pimara-8(9),15-diene (2), were isolated from the seeds of Caesalpinia minax. Their structures were determined by extensive analysis of NMR and HR-ESIMS data, and their absolute configurations were determined by electronic circular dichroism (ECD) spectra. Compound 1 was disclosed as a competitive inhibitor of PTP1B with an IC50 (the half-maximal inhibitory concentration) value of 19.44 ± 2.39 µM and a Ki (inhibition constant) value of 13.69 ± 2.72 μM. Moreover, compound 1 dose-dependently promoted insulin-stimulated glucose uptake in C2C12 myotubes through activating insulin signaling pathway. Compound 1 might be further developed as an insulin sensitizer.

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“…It has also shown antihyperglycemic, antioxidant, and anti-inflammatory effects, as well as improved blood flux and integrity of the retina [ 153 , 154 ]. The fruit has also produced improved results in terms of adiposity, hyperlipidemia, insulin resistance, and hepatic lesion related to ageing [ 155 ].…”

Section: Garcinia Species and Bioactive Compounmentioning

confidence: 99%

Medicinal Potential of Garcinia Species and Their Compounds

et al. 2020

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Garcinia is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New Caledonia, Polynesia, and Brazil. Garcinia plants contain a broad range of biologically active metabolites which, in the last few decades, have received considerable attention due to the chemical compositions of their extracts, with compounds which have been shown to have beneficial effects in several diseases. Our work had the objective of reviewing the benefits of five Garcinia species (G. brasiliensis, G. gardneriana, G. pedunculata, G. cambogia, and G. mangstana). These species provide a rich natural source of bioactive compounds with relevant therapeutic properties and anti-inflammatory effects, such as for the treatment of skin disorders, wounds, pain, and infections, having demonstrated antinociceptive, antioxidant, antitumoral, antifungal, anticancer, antihistaminic, antiulcerogenic, antimicrobial, antiviral, vasodilator, hypolipidemic, hepatoprotective, nephroprotective, and cardioprotective properties. This demonstrates the relevance of the genus as a rich source of compounds with valuable therapeutic properties, with potential use in the prevention and treatment of nontransmissible chronic diseases.

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α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice

Cited by 16 publications

References 70 publications

Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats

Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats

Pimarane Diterpenoids from the Seeds of Caesalpinia minax as PTP1B Inhibitors and Insulin Sensitizers

Medicinal Potential of Garcinia Species and Their Compounds

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