α-Haloenamides: Synthesis and Subsequent Transformations

Abstract

This short review is aimed at giving an updated overview of α- haloenamides synthesis. α-Haloenamides constitute a versatile sub-class of enamides. They can be prepared from ynamides, acetamides, or gem- dibromo olefins in the presence of N-nucleophiles and easily converted into more elaborated structures through halogen-metal exchange and transition metal catalyzed cross-coupling reactions.

Catalytic intermolecular hydrofunctionalizations of ynamides

“…Therefore, tremendous efforts have been devoted to the synthesis of such important frameworks over the past decades. 54 The hydrohalogenation of ynamides, featuring high atom- and step-economy, is arguably the simplest and most straightforward strategy. On the basis of the addition mode to deliver regio- and stereoisomers, the adducts can be classified into three types: the syn -α-adduct, anti -α-adduct and anti -β-adduct, while the syn -β-adduct has not been reported yet.…”