α-Glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice

Casirola, D.; Ferraris, Ronaldo P.

doi:10.1016/j.metabol.2006.02.011

Cited by 97 publications

(60 citation statements)

References 34 publications

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“…Our studies offer a natural key to unlock the complications in future. α-glucosidase inhibitor inhibits the disaccharide digestion and impedes the postprandial glucose excur-sion to enable overall smooth glucose profile (Casirola and Ferraris, 2006). Thus, natural products of great structural diversity are still a good source for searching for such inhibitors, thereby motivating to explore biologically active compounds from the highly diverse plants.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic potential of <i>Conocarpus lancifolius</i>

Saadullah

Chaudary

Uzair

et al. 2014

Bangladesh J Pharmacol

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Section: Resultsmentioning

confidence: 99%

Antidiabetic potential of <i>Conocarpus lancifolius</i>

Saadullah

Chaudary

Uzair

et al. 2014

Bangladesh J Pharmacol

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“…Thus, use of glycosidase inhibitor such as alpha-glucosidase inhibitors would be a prospective therapeutic agent for the effective management of diabetes. Alpha-glucosidase inhibitors inhibit the disaccharide digestion and impede the postprandial glucose excursion to enable overall smooth glucose profile (Casirola and Ferraris, 2006). Several alpha-glucosidase inhibitors have been isolated from medicinal plants to develop as an alternative drug with increased potency and lesser adverse effects than the existing drugs (Toeller, 1994).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Sayed¹,

Ezzat²,

Khalil³

et al. 2016

J. Med. Plants Res.

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Many of the health benefits associated withPolysaccharides from the plants were isolated using hot extraction method and then hydrolyzed. The polysaccharide hydrolysates were identified using high performance liquid chromatographic technique. Maximum yield of total polysaccharides identified were obtained from A 7 (12.04%), A 1 (8.51%), A 8 (8.03%), A 2 (5.32%) and A 6 (2.18%) respectively. The isolated polysaccharides were tested for antihyperglycemic activity in alloxan-induced diabetic rats and alpha glucosidase inhibitory activity. Chromatographic investigation of the polysaccharides recorded the presence of 18 saccharides, glucuronic acid, stachyose, galacturonic acid, sucrose, glucose, xylose, galactose, rhamnose, mannose, arabinose, fructose polyol, mannitol and sorbitol in the eight Aloe species, but their quantitative composition differed among the species. Glucuronic acid, stachyose and galacturonic acid were the major detected saccharides. The results of the biological activities revealed significant antihyperglycemic activities with variable degrees. After four weeks of daily administration, polysaccharides isolated from A. vera (A 1 ) and A. arborescens (A 2 ) were the most active with 40 and 44% reduction in blood glucose level, respectively. All the tested polysaccharides showed significant alpha glucosidase inhibitory activity with IC50 (µg/ml) 11.70, 14.60 and 15.80 for A 7 , A 6 and A 1 respectively. In conclusion, the tested polysaccharides contribute to the antidiabetic action of these Aloe species.

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“…We could not confirm this suppressive effect in normal rats given AE with glucose. Casirola and Ferraris have reported that an ␣-glucosidase inhibitor prevents the increase in glucose transport induced by a high carbohydrate diet in diabetic mice (29). Thus, the inhibitory effects of bitter melon on sugar transport might be more potent under conditions of higher sugar transport.…”

Section: Discussionmentioning

confidence: 99%

Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats

Uebanso

Arai

Taketani

et al. 2007

J Nutr Sci Vitaminol

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Summary Momordica charantia (bitter melon) is commonly known as vegetable insulin, but the mechanisms underlying its hypoglycemic effect remain unclear. To address this issue, the effects of bitter melon extracts on postprandial glycemic responses have been investigated in rats. An aqueous extract (AE), methanol fraction (MF) and methanol insoluble fraction (MIF) were prepared from bitter melon. An oral sucrose tolerance test revealed that administration of AE, MF or MIF each significantly suppressed plasma glucose levels at 30 min as compared with the control. In addition, the plasma insulin level at 30 min was also significantly lower after MF administration than in the control in the oral sucrose tolerance test. By contrast, these effects of bitter melon extracts were not observed in the oral glucose tolerance test. In terms of mechanism, bitter melon extracts dose-dependently inhibited the sucrase activity of intestinal mucosa with IC 50 values of 8.3, 3.7 and 12.0 mg/ mL for AE, MF and MIF, respectively. The fraction with a molecular weight of less than 1,300 (LT 1,300) obtained from MF inhibited the sucrase activity most strongly in an uncompetitive manner with an IC 50 value of 2.6 mg/mL. Taken together, these results demonstrated that bitter melon suppressed postprandial hyperglycemia by inhibition of ␣ -glucosidase activity and that the most beneficial component is present in the LT 1,300 fraction obtained from MF.

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α-Glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice

Cited by 97 publications

References 34 publications

Antidiabetic potential of <i>Conocarpus lancifolius</i>

Antidiabetic potential of <i>Conocarpus lancifolius</i>

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Extracts of Momordica charantia Suppress Postprandial Hyperglycemia in Rats

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