Zur Kenntniss des Amids und Imids der Schwefelsäure

Implementation of Diverse Synthetic and Strategic Approaches to Biologically Active Sulfamides

“…[121] In general, the imidazolidinone ring is nearly planar, certainly in the urea region. To determine whether the planar structure future is necessary for the activity, the carbonyl group (sp 2 ) was replaced with the sulfonyl group (sp 3 Diamination of cyclic sulfamide and the mechanism study. [119] Table 6.…”

“…The sulfamide (R 2 NSO 2 NR 2 ) functionality continues to receive widespread attention due to their potential to serve as prospective targets for the development and design of novel small molecule therapeutic agents, agricultural agents, and high‐affinity protein ligands [1,2] . The first synthetic method of the sulfamide formation was reported in 1892 by Traube, who prepared it from sulfuryl chloride and gaseous ammonia [3] …”

“…[1,2] The first synthetic method of the sulfamide formation was reported in 1892 by Traube, who prepared it from sulfuryl chloride and gaseous ammonia. [3] The utility of sulfamides can be identified to the capability to variably substitute with up to four different substituents conceivably, which are distributed on the two nitrogen atoms, thus offering diversity. Due to the energy difference between S and N orbitals in sulfamides resulting in the reduction of the sp 2 character of the N atoms, the geometry of the nitrogen atoms can alter from trigonal planar to pyramidal , [2b,2c,4] The two oxygen atoms at the tetrahedral S atom are well contributed to exploit dipole-dipole or hydrogen bond interactions with residues from interacting protein placed nearby.…”

“…Scheme 45). Migratory insertion allows the formation of the new sp3 NÀ C bond to furnish the intermediate 45.2. The organocopper species 45.2 is then suggested to undergo ligand exchange with the remaining nitrogen, followed by reductive elimination to afford cyclic sulfamide 45.2.…”

Syntheses and Electron Density Determination of Novel Polyimido Sulfur Ylides

“…[11] Moreover, a great variety of binary sulfur nitrogen compounds was explored. Although the synthesis of the first amino sulfur compound SO 2 (NH 2 ) 2 was reported as early as 1892 by Traube, [12] this branch of chemistry did not prosper until the Second World War. The synthesis of the first aliphatic sulfur diimide S(N n Bu) 2 by Goehring and Weis [13] in 1956 gave the so far idle chemical field the necessary impetus for a quick development (cf.…”