Zur Kenntnis des Vitamins-A aus Fischtranen

Karrer, P.; Morf, R.; Schöpp, K.

doi:10.1002/hlca.19310140511

Cited by 120 publications

(25 citation statements)

References 2 publications

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“…This theory was then confirmed 10 years later by Moore (1930). At the same time, β-carotene and retinol were being isolated and their chemical structure defined by Karrer's team (Karrer, Morf, & Schoepp, 1931) and a few years later, Isler succeeded in the total synthesis of retinol thus allowing the beginning of scientific work in the field of vitamin A (Isler, Huber, Ronco, & Kofler, 1947). The visual function of vitamin A was then elucidated by Wald (1968) and in parallel, much research was carried out increasing understanding of vitamin A metabolism and its physiological actions notably with the discovery of RA receptors (see below).…”

Section: The History and Nomenclature Of Vitamin Amentioning

confidence: 91%

Vitamin A enrichment: Caution with encapsulation strategies used for food applications

Sauvant

Cansell

Sassi

et al. 2012

Food Research International

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Section: The History and Nomenclature Of Vitamin Amentioning

confidence: 91%

Vitamin A enrichment: Caution with encapsulation strategies used for food applications

Sauvant

Cansell

Sassi

et al. 2012

Food Research International

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“…The first observations that suggested a link between vitamin A and immunity were made even before the structure of vitamin A was deduced in 1931 (70). These included the discoveries that fat in butter improved the outcome of infections in malnourished animals (98) and that vitamin A-deficient rats appeared to be more susceptible to infection (55,80).…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin A Supplementation on Immune Responses and Correlation with Clinical Outcomes

2005

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Vitamin A supplementation to preschool children is known to decrease the risks of mortality and morbidity from some forms of diarrhea, measles, human immunodeficiency virus (HIV) infection, and malaria. These effects are likely to be the result of the actions of vitamin A on immunity. Some of the immunomodulatory mechanisms of vitamin A have been described in clinical trials and can be correlated with clinical outcomes of supplementation. The effects on morbidity from measles are related to enhanced antibody production and lymphocyte proliferation. Benefits for severe diarrhea could be attributable to the functions of vitamin A in sustaining the integrity of mucosal epithelia in the gut, whereas positive effects among HIV-infected children could also be related to increased T-cell lymphopoiesis. There is no conclusive evidence for a direct effect of vitamin A supplementation on cytokine production or lymphocyte activation. Under certain circumstances, vitamin A supplementation to infants has the potential to improve the antibody response to some vaccines, including tetanus and diphtheria toxoids and measles. There is limited research on the effects of vitamin A supplementation to adults and the elderly on their immune function; currently available data provide no consistent evidence for beneficial effects. Additional studies with these age groups are needed

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“…The chemical structure of vitamin A was solved by Karrer and colleagues in 1931 [28]. Strictly applied, the term “vitamin A” describes the molecule all- trans -retinol (ROL) [29].…”

Section: Vitamin a Is The Molecular Precursor Of Ramentioning

confidence: 99%

Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos

Metzler

Sandell

2016

Nutrients

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Embryonic development is orchestrated by a small number of signaling pathways, one of which is the retinoic acid (RA) signaling pathway. Vitamin A is essential for vertebrate embryonic development because it is the molecular precursor of the essential signaling molecule RA. The level and distribution of RA signaling within a developing embryo must be tightly regulated; too much, or too little, or abnormal distribution, all disrupt embryonic development. Precise regulation of RA signaling during embryogenesis is achieved by proteins involved in vitamin A metabolism, retinoid transport, nuclear signaling, and RA catabolism. The reversible first step in conversion of the precursor vitamin A to the active retinoid RA is mediated by retinol dehydrogenase 10 (RDH10) and dehydrogenase/reductase (SDR family) member 3 (DHRS3), two related membrane-bound proteins that functionally activate each other to mediate the interconversion of retinol and retinal. Alcohol dehydrogenase (ADH) enzymes do not contribute to RA production under normal conditions during embryogenesis. Genes involved in vitamin A metabolism and RA catabolism are expressed in tissue-specific patterns and are subject to feedback regulation. Mutations in genes encoding these proteins disrupt morphogenesis of many systems in a developing embryo. Together these observations demonstrate the importance of vitamin A metabolism in regulating RA signaling during embryonic development in vertebrates.

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Zur Kenntnis des Vitamins-A aus Fischtranen

Cited by 120 publications

References 2 publications

Vitamin A enrichment: Caution with encapsulation strategies used for food applications

Vitamin A enrichment: Caution with encapsulation strategies used for food applications

Effects of Vitamin A Supplementation on Immune Responses and Correlation with Clinical Outcomes

Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos

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