ZOUSH Ointment with the Properties of Antibacterial Moreover, Burn Wound Healing

Meskini, Maryam; Gholami, Maryam; Bahadoran, H; Zaree, Ali; Esmaeili, Davoud

doi:10.1007/s10989-019-09841-3

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…In the study by Davoodi et al, the metabolite profiling of methanolic extract from aerial parts of Satureja khuzistanica Jamzad was evaluated using HPLC-PDAESI (27). In the study of Meskini et al, the antibacterial and wound healing effects of Satureja khuzestanica in the form of an oint- ment formulation were investigated, and its antibacterial activity and acceleration in wound healing were also confirmed, which was consistent with our study result (20,25). In the study of Jalalvand et al, the antibacterial effects and apoptosis of gastric cancer cells were examined using flow cytometry -a technique which was also used in our study (27).…”

Section: Discussionsupporting

confidence: 87%

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Determination of the Antibacterial and Apoptotic Effects of Carvacrol and Anti-cancer Peptide

Elahi

Hekmati

Esmaeili

et al. 2022

Jentashapir J Cell Mol Biol

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Background: Treating gastric cancer and antibacterial remains a major challenge. There have been many reports about the positive effects of carvacrol and anti-cancer peptides contributing to cancer inhibition and antibacterial activities. Objectives: This study aimed to determine antibacterial and anti-cancer effects of modified carvacrol against AGS gastric cancer cell line by adopting the flow cytometry technique. Methods: The treatment of cells with modified carvacrol containing anti-cancer peptide was used to evaluate the apoptosis effect against the AGS cell line. The treatment of AGS cells was performed by adopting flow cytometry in order to evaluate the apoptosis. Disc diffusion and MIC methods were used to determine the antibacterial effects. Results: The results showed that cells treated with carvacrol and anti-cancer peptide at a concentration of 0.125 µg/mL induced a 31-fold apoptotic effect. Phosphate buffered saline was used as the control group for the treatment that induced a 63% apoptotic effect on the AGS cell line. The results of antibacterial activity suggested that the modified carvacrol had antibacterial properties against Staphylococcus aureus (MIC = 6 µg/mL, Growth inhibition zone with diameter of 20mm) and Escherichia coli (12 µg/mL, Growth inhibition zone with diameter 16). The results also revealed that the minimum inhibitory concentration of the compound was 6 µg/mL for Staphylococcus aureus, while this value was 12 µg/mL for Escherichia coli. Conclusions: Since the anti-cancer properties of modified carvacrol mixture with anti-cancer peptide induced 1.25 times more than phosphate-buffered saline, the above combination may have been used to treat and induce apoptotic activity against gastric cancer cell lines.

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Section: Discussionsupporting

confidence: 87%

“…Carvacrol is the most effective compound of the Satureja khuzestanica plant, and according to researchers, this compound can inhibit cancer cells (19,20).…”

Section: Introductionmentioning

confidence: 99%

Determination of the Antibacterial and Apoptotic Effects of Carvacrol and Anti-cancer Peptide

Elahi

Hekmati

Esmaeili

et al. 2022

Jentashapir J Cell Mol Biol

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“…The World Health Organization (WHO) has identified TB as the leading cause of death from a single infectious agent worldwide, surpassing even the human immunodeficiency virus (HIV) (Kasavandi et al 2023 ). MTB is the most prevalent infection and one of thirteen causes of mortality due to infections in the world (Meskini et al 2020 , 2021 ; Tilwani et al 2023 ). These alarming statistics underscore the pressing need for innovative diagnostic tools and approaches to enhance TB detection, treatment, and control.…”

Section: Introductionmentioning

confidence: 99%

New insight in molecular detection of Mycobacterium tuberculosis

Mousavi-Sagharchi,

Afrazeh,

Seyyedian-Nikjeh

et al. 2024

AMB Expr

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Mycobacterium tuberculosis, the causative agent of tuberculosis, is a pathogenic bacterium that has claimed millions of lives since the Middle Ages. According to the World Health Organization’s report, tuberculosis ranks among the ten deadliest diseases worldwide. The presence of an extensive array of genes and diverse proteins within the cellular structure of this bacterium has provided us with a potent tool for diagnosis. While the culture method remains the gold standard for tuberculosis diagnosis, it is possible that molecular diagnostic methods, emphasis on the identification of mutation genes (e.g., rpoB and gyrA) and single nucleotide polymorphisms, could offer a safe and reliable alternative. Over the past few decades, as our understanding of molecular genetics has expanded, methods have been developed based on gene expansion and detection. These methods typically commence with DNA amplification through nucleic acid targeted techniques such as polymerase chain reaction. Various molecular compounds and diverse approaches have been employed in molecular assays. In this review, we endeavor to provide an overview of molecular assays for the diagnosis of tuberculosis with their properties (utilization, challenges, and functions). The ultimate goal is to explore the potential of replacing traditional bacterial methods with these advanced molecular diagnostic techniques.

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“…The definition of productivity, according to the European Productivity Agency (EPA), is the ratio of returns to resources consumed. On the other hand, productivity is the ratio of goods or services produced to the resources used during production ( 7 , 8 ). Productivity today is one of the most important factors in achieving the goals and progress of organizations.…”

Section: Introductionmentioning

confidence: 99%

Key Factors to Improve Pharmaceutical Industry's R&D Productivity: A Case Study of Iranian Pharmaceutical Holding

Shabani

Rajabi

Alipanahi

et al. 2022

Med. J. Islam. Republ. Iran

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Background: Productivity is one of the most important factors of development in pharmaceutical companies, which is in direct contact with research and development (R&D) employees. The study aimed to identify and prioritize the effective factors for improving the R&D Activities of Iranian pharmaceutical holding. Methods: This case study was performed by a questionnaire designed into two sectors, demographic profile data, and nine attitude factors. The questionnaire was distributed to Iranian pharmaceutical holding. The main sampling targets were managers and employees of the R&D department. Cronbach's alpha considered the reliability of the questionnaire, and the validity of the questionnaire was measured by the content validity method. Descriptive analyses were done using frequency, percentage, mean, standard deviation, and variance. Also, Kolmogorov–Smirnov, Pearson correlation coefficient, F test, and Friedman test were used as comparative and inferential analyses. Results: A total of 65 questionnaires were collected (43 are men and 22 are women) from 11 companies of an Iranian pharmaceutical holding. The 5-10 years of work experience with doctorate education levels were common. Based on the ranking done on the data using the Friedman test method, economic factors were recognized as the most important and individual factors as the least important factors. People aged 35-40 years had a higher frequency. Furthermore, there was a significant difference between considered factors and productivity of R&D. Conclusion: All current study's hypotheses show a significant difference in productivity in Iranian pharmaceutical companies.

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ZOUSH Ointment with the Properties of Antibacterial Moreover, Burn Wound Healing

Cited by 8 publications

References 27 publications

Determination of the Antibacterial and Apoptotic Effects of Carvacrol and Anti-cancer Peptide

Determination of the Antibacterial and Apoptotic Effects of Carvacrol and Anti-cancer Peptide

New insight in molecular detection of Mycobacterium tuberculosis

Key Factors to Improve Pharmaceutical Industry's R&D Productivity: A Case Study of Iranian Pharmaceutical Holding

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