Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting

Zhao, Zhengdong; Chen, Zong-Ming; Xiang, Xinkuan; Hu, Mengna; Xie, Hengchang; Jia, Xiaoning; Cai, Fang; Cui, Yuting; Chen, Zijun; Qian, Lechen; Liu, Jiashu; Shang, Congping; Yang, Yi‐Qing; Ni, Xinyan; Sun, Wenzhi; Hu, Ji; Cao, Peng; Li, Hao‐Hong; Shen, Wei

doi:10.1038/s41593-019-0404-5

Cited by 142 publications

(146 citation statements)

References 57 publications

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“…Motion plays a crucial role in predator-prey interactions. Predator and prey both use motion cues to detect each other using these to make decisions about when and how to strike or whether and how to escape (Carr and Christensen-Dalsgaard, 2015; Catania et al, 2008; Friedel et al, 2008; Zhao et al, 2019). Furthermore, prey animals also use motion cues from other prey as an indirect cue of a predator’s presence (Handegard et al, 2012; Hingee and Magrath, 2009; Pereira et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Behavioral and neuronal underpinnings of safety in numbers in fruit flies

Ferreira

Moita

2019

Preprint

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13Living in a group allows individuals to decrease their defenses enabling other beneficial 14behaviors such as foraging. The detection of a threat through social cues is widely reported, 15however the safety cues that guide animals to break away from a defensive behavior and 16resume alternate activities remain elusive. Here we show that fruit flies displayed a graded 17 decrease in freezing behavior, triggered by an inescapable threat, with increasing group 18 sizes. Furthermore, flies used the cessation of movement of other flies as a cue of threat and 19 its resumption as a cue of safety. Finally, we found that lobula columnar neurons, LC11, 20 mediate the propensity for freezing flies to resume moving in response to the movement of 21 others. By identifying visual motion cues, and the neurons involved in their processing, as 22the basis of a social safety cue this study brings new insights into the neuronal basis of 23 safety in numbers. 24 25

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Section: Discussionmentioning

confidence: 99%

Behavioral and neuronal underpinnings of safety in numbers in fruit flies

Ferreira

Moita

2019

Preprint

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“…Prey capture can serve as a useful paradigm for investigating visually guided behavior. Recent studies have shown that mice use vision to accurately orient towards and pursue cricket prey [4] , and have begun to uncover neural circuit mechanisms that mediate both the associated sensory processing and motor output [11][12][13][14] . Importantly, prey capture also provides a context to investigate how mice actively acquire visual information, as it entails identifying and tracking a localized and ethological sensory input during freely moving behavior.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of gaze control during prey capture in freely moving mice

Michaiel

Abe

Niell

2020

Preprint

102

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Many studies of visual processing are conducted in unnatural conditions, such as head-and gaze-fixation.As this radically limits natural exploration of the visual environment, there is much less known about how animals actively use their sensory systems to acquire visual information in natural, goal-directed contexts.Recently, prey capture has emerged as an ethologically relevant behavior that mice perform without training, and that engages vision for accurate orienting and pursuit. However, it is unclear how mice target their gaze during such natural behaviors, particularly since, in contrast to many predatory species, mice have a narrow binocular field and lack foveate vision that would entail fixing their gaze on a specific point in the visual field. Here we measured head and bilateral eye movements in freely moving mice performing prey capture. We find that the majority of eye movements are compensatory for head movements, thereby acting to stabilize the visual scene. During head turns, however, these periods of stabilization are interspersed with non-compensatory saccades that abruptly shift gaze position. Analysis of eye movements relative to the cricket position shows that the saccades do not preferentially select a specific point in the visual scene. Rather, orienting movements are driven by the head, with the eyes following in coordination to sequentially stabilize and recenter the gaze. These findings help relate eye movements in the mouse to other species, and provide a foundation for studying active vision during ethological behaviors in the mouse.

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“…Animals exhibit a range of aggressive behaviors (Blanchard et al, 2003; Moyer, 1968) essential for survival, reproduction, and social hierarchy establishment (Nelson and Trainor, 2007), while pathological aggression and the inability to control aggressive states cause serious social problems (Coccaro, 2012; Davidson, 2000; Siegel and Victoroff, 2009). Distinct regions in the mouse brain have been shown to be essential for male (Chamero et al, 2007; Hong et al, 2014; Lee et al, 2014; Leroy et al, 2018; Lin et al, 2011; Stagkourakis et al, 2018; Stowers et al, 2002; Todd et al, 2018; Unger et al, 2015; Yang et al, 2013; Yang et al, 2017; Zelikowsky et al, 2018), female (Hashikawa et al, 2017; Unger et al, 2015), predatory (Han et al, 2017; Li et al, 2018; Park et al, 2018; Shang et al, 2019; Zhao et al, 2019), and infant-directed (Autry et al, 2019; Chen et al, 2019; Isogai et al, 2018; Trouillet et al, 2019) aggressive behaviors. Furthermore, studies from some brain regions that have been examined for more than one type of aggressive behaviors suggest that different behaviors are regulated by distinct, dedicated neural circuits under specific internal and external conditions (Chen and Hong, 2018; Chen et al, 2019; Han et al, 2017; Hashikawa et al, 2017; Isogai et al, 2018; Yang et al, 2017; Zelikowsky et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Activation of the GABAergic neurons in the medial amygdala (MeA) promotes pup-directed aggression in male but hardly in female mice (Chen et al, 2019). In addition, activation of neurons in the central amygdala (Han et al, 2017), zona incerta (Shang et al, 2019; Zhao et al, 2019), or medial preoptic area (Park et al, 2018) triggers predatory aggression but not intra-conspecific aggression.…”

Section: Introductionmentioning

confidence: 99%

A Substantia Innominata-midbrain Circuit Controls a General Aggressive Response

Zhu

Yang

et al. 2020

Preprint

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SUMMARYAnimals display various aggressive behaviors essential for survival, while ‘uncontrollable’ attacks and abnormal aggressive states have massive social costs. Neural circuits regulating specific forms of aggression under defined conditions have been described, but whether there are circuits governing a general aggressive state to promote diverse aggressive behaviors remains unknown. Here, we found that posterior substantia innominata (pSI) neurons responded to multiple aggression-provoking cues with graded activity of differential dynamics, predicting the aggressive state and the topography of aggression in mice. Activation of pSI neurons projecting to the periaqueductal gray (PAG) increased aggressive arousal and robustly initiated/promoted all the types of aggressive behavior examined in an activity level-dependent manner. Inactivation of the pSI circuit largely blocked diverse aggressive behaviors, but not mating. By encoding a general aggressive state, the pSI-PAG circuit universally drives multiple aggressive behaviors and thus may provide a potential target for alleviating human pathological aggression.

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Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting

Cited by 142 publications

References 57 publications

Behavioral and neuronal underpinnings of safety in numbers in fruit flies

Behavioral and neuronal underpinnings of safety in numbers in fruit flies

Dynamics of gaze control during prey capture in freely moving mice

A Substantia Innominata-midbrain Circuit Controls a General Aggressive Response

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