ZnO@ZIF-8 Nanoparticles as Nanocarrier of Ciprofloxacin for Antimicrobial Activity

Abstract

Numerous antimicrobial drugs have been prescribed to kill or inhibit the growth of microbes such as bacteria, fungi, and viruses. Despite the known therapeutic efficacy of these drugs, inefficient delivery could result in an inadequate therapeutic index and several side effects. In order to overcome this adversity, the present study investigated antibiotic drug loading in zeolitic imidazolate frameworks (ZIFs), in association with ZnO nanoparticles with known antimicrobial properties. In an economic synthesis method, the ZnO surface was first converted to ZIF-8 with 2-methylimidazole as a ligand, resulting in a ZnO@ZIF-8 structure. This system enables the high drug-loading efficiency (46%) of an antimicrobial drug, ciprofloxacin, within the pores of the ZIF-8. This association provides a control of the release of the active moieties, in simulated body-fluid conditions, with a maximum of 67% released in 96 h. The antibacterial activities of ZnO@ZIF-8 and CIP-ZnO@ZIF-8 were tested against the Gram-positive Staphylococcus aureus strain and the Gram-negative Pseudomonas aeruginosa strain, showing good growth inhibition. This result was obtained by combining ZnO@ZIF-8 with ciprofloxacin in a minimal inhibitory concentration (MIC) that was 10 times lower than ZnO@ZIF-8 for S. aureus and 200 times lower for P. aeruginosa, suggesting that CIP-ZnO@ZIF-8 may have potential application in prolonged antimicrobial treatment.

Nanoparticles of Cerium-Doped Zeolitic Imidazolate Framework-8 Promote Soft Tissue Integration by Reprogramming the Metabolic Pathways of Macrophages

“…Here, we used ZIF-8 NPs instead of other biomaterials including mesoporous bioglass as vehicles of Ce ions, although mesoporous bioglass has many advantages . Aided by the generation of ROS and the accumulation of increased electrostatic attraction on the bacterial cell membrane, Zn 2+ is a potent antibacterial agent effective against both Gram-negative and Gram-positive bacteria. , ZIF-8 NPs are antibacterial when Zn 2+ is released sustainedly from nano ZIF-8. In this study, 2%, 4%, and 8% Ce@ZIF-8 all demonstrated a sustained release of Zn and Ce ions in complete DMEM (Figure E,F).…”

Amination of Polyurethane for Designing Infection-Resistant Surfaces

“…The alteration in the chemical composition, thermal behavior, and crystalline structure of these modified PU surfaces was evaluated using water contact angle measurement, FTIR, DSC, and XRD, respectively. Ciprofloxacin (a second-generation fluoroquinolone) , was used as a model drug for this study. The drug was incorporated onto the surface by using the dip-coating technique.…”

Dissolved Carbon Dioxide: The Lifespan of Staphylococcus aureus and Enterococcus faecalis in Bottled Carbonated Mineral Water

“…Staphylococcus aureus were cultivated on blood agar and exposed to pure CO 2 , a standard anaerobic gas, or air, over a period of 24 h [ 4 ]. Recent studies on methicillin-resistant S. aureus (MRSA) were concerned with antibacterial material and pathogeny [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The survival of Escherichia coli , P. aeruginosa , Enterobacter cloacae , and Klebsiella pneumonia were investigated in bottled still water and demonstrated a reduction of colony-forming units (CFUs) over a period of twenty days [ 13 ].…”