Zinkkomplexe von Aminosäuren und Peptiden, 2^[1]. Koordination einfacher Histidin‐Derivate an Zink

Abstract

The bis(L-histidine)ZnCl, complex 1 is likely to have tetrahe-histidine derivative N"-acetylhistidine the complexes (Acdral ZnN,Cl, coordination. For the compound @-histidine)-His)ZnX . H,O (5, X = C104, BF4) have been isolated which ZnCl, . HCl (2) a structure determination has revealed a tetra-are coordination polymers in the solid state. From pH-dehedral ZnOC1, coordination. Of the C-protected histidine de-pendent 13C-NMR studies it is concluced that in solution the rivatives His-OMe and His-NH, and zinc salts of non-imidazole N and carboxyl 0 are coordinated to zinc in (Accoordinating anions the complexes (His-OMe),ZnXz (3) and His)Zn and (Ac-His),Zn units. The doubly protected histidine (His-NH,),Zn(C10,)2 (4) were obtained. A structure determi-derivative Bz-His-OMe acts as a monodentate ligand forming nation of (His-OMe),Zn(BPh,), . H 2 0 has revealed a ZnN4 co-the tetrahedral complexes (Bz-Hi~-0Me)~Zn(C10~), (6) and ordination with chelating histidine units. Of the N-protected [(Bz-His-OMe),Zn(2,9-dimethyl-o-phenanthroline)](C~O4)~ (7).

Zinc Thiolate Complexes of (N,N,S)‐Tridentate Ligands for the Modeling of Thiolate Alkylating Enzymes

“…[27] Organic starting materials were obtained commercially. Ligands L 1 [14] and L 3 [20] were prepared according to the published procedures.…”

New Tris(thioimidazolyl)borate Ligands and Some Zinc Complexes Thereof

“…[35] All procedures for the ligand synthesis were performed under an inert gas. The isolation procedures described below yielded the new complexes spectroscopically pure.…”

(Neocuproin)zinc Thiolates: Attempts at Modeling Cobalamin‐Independent Methionine Synthase

“…[41] Starting materials were obtained commercially, except for Zn[N(SiMe 3 ) 2 ] 2 , [42] o-(mercaptomethyl)thiophenol, [43] and o-bis-(mercaptomethyl)benzene. [44] The methyl thioethers resulting from the methylations have been described [45Ϫ48] and were identified by their 1 H NMR spectra.…”