Zinc therapy and distribution in psoriasis

Voorhees, J. J.

doi:10.1001/archderm.100.6.669

Cited by 19 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidermal and dermal zinc in normal skin were increased in the three groups, con firming results in the literature [5,10], However, in suction blister fluid, which has a content similar to that of the interstitial sector [11], the zinc levels remained normal in groups 1 and 2, whereas they dropped markedly in the pustular psoriasis group, parallel to the decrease in plasma zinc.…”

Section: Discussionsupporting

confidence: 86%

“…When psoriasis groups were considered plasma zinc was normal in the palmoplantar psoriasis and vulgaris psoriasis groups whereas a marked decrease was seen in the extensive pustular psoriasis group. These findings confirm the results of Thune [8,9] in 4 cases of pustular psoriasis and may ac count for the conflicting results in the litera ture for plasma zinc in psoriatic patients (ta ble III) [1][2][3][4][5]10]. Even though there was a mild inflammatory syndrome in the group 3 population, this syndrome was also present in group 1 and thus could not in itself ac count for the significant decrease in plasma [10] Zinc in group 3.…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

Plasma Zinc Is Decreased Only in Generalized Pustular Psoriasis

et al. 1986

View full text Add to dashboard Cite

Plasma and cutaneous zinc were studied in 22 psoriatic patients and 14 controls. The psoriatics were divided into three groups: 10 extensive psoriasis vulgaris, 5 palmoplantar psoriasis and 7 extensive pustular psoriasis. Low plasma zinc and decreased in vitro chemotaxis of polymorphonuclear leukocytes were found only in extensive pustular psoriasis, whereas zinc was not decreased but rather elevated in skin. This explains why conflicting results on plasma zinc have been previously reported in psoriasis and confirms that cutaneous zinc depletion is not a feature of psoriasis.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 84%

Plasma Zinc Is Decreased Only in Generalized Pustular Psoriasis

et al. 1986

View full text Add to dashboard Cite

show abstract

“…The studies of plasma zinc in psoriatics resulted in confiicting results with lowered (Voorhees et al, 1969;Greaves & Boyde, 1967), and normal (Withers et al, 1968) levels recorded. A possible reason for confiicting results was the varying surface area involvement in subjects chosen (Greaves 1970) with significant loss of zinc in psoriatic scale (Ponomareva, 1966J Molin & Webster, 1973.…”

mentioning

confidence: 99%

Plasma zinc in psoriasis: relation to surface area involvement

McMillan

Rowe

1983

Br J Dermatol

View full text Add to dashboard Cite

Plasma zinc, serum albumin and alkaline phosphatase (a zinc-dependent enzyme) were measured in thirty-five psoriatics and their age- and sex-matched controls. No significant difference was seen between these two groups as a whole, but psoriatics with less than 10% surface involvement had significantly higher mean plasma zinc levels than their respective control group. Psoriatic patients also showed a relationship between the extent of surface involvement and the plasma zinc level, those with more extensive involvement having lower levels than those with minimal involvement. The differences were not due to disturbances in serum albumin, and no abnormalities in serum alkaline phosphatase were observed.

show abstract

“…poor index of the zinc status of the body as a whole in these patients. Patients with normal serum zinc concentrations are usually assumed not to be zinc deficient and thus are likely to be excluded from trials of treatment with zinc from which they might benefit: zinc has previously been advocated for certain skin diseases including psoriasis, leg ulcers and the skin lesions of leprosy (Voorhees et al, 1969;Husain, 1969;Hallbrook & Lanner, 1972;Oon et al, 1974). It is equally possible that patients reported to have low serum concentrations of zinc are not zinc deficient and that the low concentrations in fact results from an altered distribution of zinc within the body.…”

mentioning

confidence: 99%

Whole body monitoring and other studies of zinc-65 metabolism in patients with dermatological diseases

et al. 1976

View full text Add to dashboard Cite

SiunmaryThe retention of-an oral dose of **'Zn was measured in patients with skin disease over a period of 231 days using a whole body monitor. The retention was compared with available data on healthy subjects. No significant differences were observed for the group as a whole. In a small clinical subgroup with venous leg ulcers, a lower retention and a shorter biological half life of^2 n were found. Faecal and urinary loss of ^^Zn were measured over the first 7 days, and indirectly confirmed the retention values obtained by whole body counting. Whole blood and plasma *' -^Zn concentrations were studied up to 192 days. No significant differences were observed when compared with other disease groups. The activity profiles of some patients appeared to confirm the liver as the organ of early preferential uptake. A close similarity of the metabolic behaviour of zinc and iron was observed. The minimum daily requirements of zinc to maintain body stores is assessed as 24-4-2 mg.

show abstract

Zinc therapy and distribution in psoriasis

Cited by 19 publications

References 0 publications

Plasma Zinc Is Decreased Only in Generalized Pustular Psoriasis

Plasma Zinc Is Decreased Only in Generalized Pustular Psoriasis

Plasma zinc in psoriasis: relation to surface area involvement

Whole body monitoring and other studies of zinc-65 metabolism in patients with dermatological diseases

Contact Info

Product

Resources

About