Zinc Supplementation Forms Influenced Zinc Absorption and Accumulation in Piglets

Liu, Fenfen; Azad, Md. Abul Kalam; Li, Zhihe; Li, Jing; Mo, Kaibin; Ni, Hengjia

doi:10.3390/ani11010036

Cited by 11 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrary to the present study, Liu et al [23], Li et al [24] and Xie et al [25] reported ZnMet had no effect on ADG, ADFI, and FCR in weaned piglets. The discrepancies may be attributed to variations in the bioavailability of diverse amino acid-chelated zinc and differences in the types of diets consumed.…”

Section: Discussioncontrasting

confidence: 99%

“…In this study, the supplementation of 75-100 mg/kg ZnVal showed a higher concentration of zinc in liver and dietary supplementation with 50-100 mg/kg ZnVal increased the concen-trations of zinc in the heart, spleen and kidney, indicating that the addition of ZnVal improved the absorption of trace elements. These results were partly in accordance with the results of Liu et al [23], who reported that dietary supplementation with 150 mg/kg ZnMet showed a higher concentration of zinc in liver in piglets. Furthermore, Zhang et al [43], reported that the supplementation of ZnMet to growing-nishing pigs signi cantly increased the concentrations of zinc in the muscle, liver, kidney and serum in comparison with the ZnSO 4 supplementation of growing-nishing pigs and Jahanian et al [44] found that incremental levels of ZnMet increased zinc concentrations in liver and thymus of broiler chicks.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Effects of dietary valine chelated zinc supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets

Zhang

Peng

et al. 2023

Preprint

View full text Add to dashboard Cite

This study was conducted to investigate the effects of dietary valine chelated zinc (ZnVal) supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets. A total of 240 healthy 35-day-old weaned piglets [Duroc × (Landrace × Yorkshire), average weight 10.70 ± 0.14 kg] were randomly divided into five groups with six replicate pens and eight piglets per pen. Dietary treatments were a corn–soybean meal basal diet supplemented with 0, 25, 50, 75, and 100 mg/kg ZnVal, respectively. The experiment lasted for 28 days. Results showed that average daily gain (ADG) was increased (P < 0.05) by ZnVal with 75–100 mg/kg supplementation on days 15–28 and with 50–100 mg/kg supplementation on days 1–28. Supplementation of 25–100 mg/kg ZnVal reduced (P < 0.01) the diarrhea rate of weaned piglets at 1 to 14 days and 1 to 28 days. Dietary supplementation with 25–100 mg/kg ZnVal increased (P < 0.05) copper/zinc-superoxide dismutase (Cu/Zn-SOD) and decreased malonaldehyde (MDA) activities in the serum on day 14 and 28. Supplementation of 25–100 mg/kg ZnVal increased (P < 0.05) glutathione peroxidase (GSH-Px) activity in serum on day 14. In addition, supplementation of 75 mg/kg ZnVal increased (P < 0.05) the superoxide dismutase (SOD) activity in liver and Cu/Zn-SOD, total antioxidant capacity (T-AOC) with 25–100 mg/kg ZnVal supplementation in liver increased (P < 0.05). Higher (P < 0.05) concentrations of IgG in the serum were measured from piglets supplemented with 75–100 mg/kg ZnVal on day 14 and dietary supplementation with 25–100 mg/kg ZnVal increased the level of immunoglobulin G (IgG) in serum on in serum day 28 (P < 0.05). In addition, higher (P < 0.05) concentration of immunoglobulin A (IgA) in the duodenum and ileum were measured from piglets supplemented with 75 mg/kg ZnVal and the supplementation of 25–100 mg/kg ZnVal also showed a higher (P < 0.05) concentration of immunoglobulin G (IgG) in duodenum. Supplementation of 50–100 mg/kg ZnVal increased the villus height and villus height/crypt depth of jejunum (P < 0.05). Moreover, dietary supplementation with 75–100 mg/kg ZnVal showed a higher (P < 0.05) concentration of zinc in liver and supplementation of 50–100 mg/kg ZnVal increased (P < 0.05) the concentration of zinc in the heart, spleen and kidney. In conclusion, dietary supplementation with ZnVal improves ADG, antioxidant ability, and immunity in weaned piglets.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Effects of dietary valine chelated zinc supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets

Zhang

Peng

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…qPCR was performed in a 10 μl reaction volume using a SYBR Premix Ex Taq kit (Takara, Japan). PCR amplification was performed according to a previous study ( 18 ).…”

Section: Methodsmentioning

confidence: 99%

Superiority of Microencapsulated Essential Oils Compared With Common Essential Oils and Antibiotics: Effects on the Intestinal Health and Gut Microbiota of Weaning Piglet

Liu

et al. 2022

Front. Nutr.

Self Cite

View full text Add to dashboard Cite

Essential oils (EOs) have long been considered an alternative to antibiotics in the breeding industry. However, they are unstable and often present unpleasant odors, which hampers their application. Microencapsulation can protect the active gradients from oxidation and allow them to diffuse slowly in the gastrointestinal tract. The purpose of this study was to investigate the effect of microencapsulation technology on the biological function of EOs and the possibility of using microencapsulate EOs (MEEOs) as an alternative to antibiotics in weaning piglets. First, we prepared MEEOs and common EOs both containing 2% thymol, 5% carvacrol and 3% cinnamaldehyde (w/w/w). Then, a total of 48 weaning piglets were randomly allotted to six dietary treatments: (1) basal diet; (2) 75 mg/kg chlortetracycline; (3) 100 mg/kg common EOs; (4) 500 mg/kg common EOs; (5) 100 mg/kg MEEOs; and (6) 500 mg/kg MEEO. The trial lasted 28 days. The results showed that piglets in the 100 mg/kg MEEOs group had the lowest diarrhea index during days 15–28 (P < 0.05). In addition, 100 mg/kg MEEOs significantly alleviated intestinal oxidative stress and inflammation (P < 0.05), whereas 500 mg/kg common EOs caused intestinal oxidative stress (P < 0.05) and may lead to intestinal damage through activation of inflammatory cytokine response. MEEOs (100 mg/kg) significantly reduced the ratio of the relative abundance of potential pathogenic and beneficial bacteria in the cecum and colon (P < 0.05), thus contributing to the maintenance of intestinal health. On the other hand, chlortetracycline caused an increase in the ratio of the relative abundance of potential pathogenic and beneficial bacteria in the colon (P < 0.05), which could potentially have adverse effects on the intestine. The addition of a high dose of MEEOs may have adverse effects on the intestine and may lead to diarrhea by increasing the level of colonic acetic acid (P < 0.05). Collectively, the results suggest that microencapsulation technology significantly promotes the positive effect of EOs on the intestinal health of weaning piglets and reduces the adverse effect of EOs, and 100 mg/kg MEEOs are recommended as a health promoter in piglets during the weaning period.

show abstract

“…It is reported that ZnMet had a higher bioavailability among zinc sources ( 41 ); therefore, we further detected the concentration of zinc in serum and tissues, which can reflect the absorption and utilization of zinc and is also used as an indicator to evaluate the nutritional status of the body ( 42 ). An increase in serum zinc concentration indicates that zinc metabolism is enhanced ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Inorganic or Amino Acid-Chelated Zinc on Mouse Myoblast Growth in vitro and Growth Performance and Carcass Traits in Growing-Finishing Pigs

et al. 2022

View full text Add to dashboard Cite

This study aimed to investigate the effects of the supplementation of different sources of zinc on mouse myoblast growth in vitro and the growth performance and carcass traits in growing-finishing pigs. In the in vitro trial, 25 or 75 mM zinc sulfate (ZnSO4), methionine-chelated zinc (ZnMet), and glycine-chelated zinc (ZnGly) were co-cultured with the myoblast during proliferation and differentiation. The results showed that the amino acid-chelated zinc supplementation, especially ZnMet, enhances cell proliferation and differentiation in mouse myoblast, and regulates the distribution in S and G2/M phases (P < 0.05). Meanwhile, the protein expression levels of the mammalian target of rapamycin pathways were up-regulated after treatment with 25 μM ZnMet (P < 0.05), which is consistent with the results of the enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway in the transcriptome analysis. In the in vivo trial, 27 Duroc × (Landrace × Large White) pigs with an initial average weight of 31.62 ± 0.36 kg were divided into three groups with nine replicates per treatment. The dietary treatment groups were as follows: (1) ZnSO4 group, basal diet +75 mg/kg ZnSO4; (2) ZnMet group, basal diet +75 mg/kg ZnMet; and (3) ZnGly group, basal diet +75 mg/kg ZnGly. The whole trial lasted for 75 days. Increased final body weight, average daily gain, and decreased F/G were noted in the ZnMet group (P < 0.05). Moreover, the ZnMet group had higher carcass weight and loin eye area (P = 0.05). The ZnMet and ZnGly group both had lower serum total protein (P < 0.05), while the ZnMet group had higher serum alkaline phosphatase (P < 0.05). Also, the addition of ZnMet showed higher concentrations of zinc and iron in muscle, kidney, and serum (P < 0.05), improving the deposition and availability of micronutrients. In conclusion, amino acid-chelated zinc, particularly ZnMet, had the best effect, which could improve growth in vitro and increase growth performance while boosting bioavailability in growing-finishing pigs, ultimately, enhancing muscle mass, providing a theoretical basis and guidance for the future use of amino acid-chelated zinc to effectively replenish energy in animal nutrition and production.

show abstract

Zinc Supplementation Forms Influenced Zinc Absorption and Accumulation in Piglets

Cited by 11 publications

References 38 publications

Effects of dietary valine chelated zinc supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets

Effects of dietary valine chelated zinc supplementation on growth performance, antioxidant capacity, immunity, and intestine health in weaned piglets

Superiority of Microencapsulated Essential Oils Compared With Common Essential Oils and Antibiotics: Effects on the Intestinal Health and Gut Microbiota of Weaning Piglet

Comparison of the Effects of Inorganic or Amino Acid-Chelated Zinc on Mouse Myoblast Growth in vitro and Growth Performance and Carcass Traits in Growing-Finishing Pigs

Contact Info

Product

Resources

About