Zinc supplementation for the treatment or prevention of disease: Current status and future perspectives

Haase, Hajo; Overbeck, Silke; Rink, Lothar

doi:10.1016/j.exger.2007.12.002

Cited by 170 publications

(122 citation statements)

References 129 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…This is a common finding in diabetic patients and can be related to hyperzincuria (16). It is well established that zinc supplementation effectively prevents the metabolic syndrome and diabetes and its secondary complications (13,38). In our study, ZnO treatment to diabetic rats improved serum zinc status in a time-and dose-dependent manner.…”

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

2015

View full text Add to dashboard Cite

Abstract. In the current study, antidiabetic activity and toxic effects of zinc oxide nanoparticles (ZnO) were investigated in diabetic rats compared to zinc sulfate (ZnSO 4 ) with particular emphasis on oxidative stress parameters. One hundred and twenty male Wistar rats were divided into two healthy and diabetic groups, randomly. Each major group was further subdivided into five subgroups and then orally supplemented with various doses of ZnO (1, 3, and 10 mg/kg) and ZnSO 4 (30 mg/kg) for 56 consecutive days. ZnO showed greater antidiabetic activity compared to ZnSO 4 evidenced by improved glucose disposal, insulin levels, and zinc status. The altered activities of erythrocyte antioxidant enzymes as well as raised levels of lipid peroxidation and a marked reduction of total antioxidant capacity were observed in rats receiving ZnO. ZnO nanoparticles acted as a potent antidiabetic agent, however, severely elicited oxidative stress particularly at higher doses.

show abstract

Section: Discussionmentioning

confidence: 58%

“…A wide range of biological activities such as cell division (8), immune responses regulation (9,10), epithelial cell integrity (11), and the proper function of more than 300 enzymes from all enzyme families (12,13) are tightly correlated with zinc.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats

2015

View full text Add to dashboard Cite

show abstract

“…7 Since, the role of Zinc in insulin synthesis and secretion has been established over the years, [18][19][20][21] it is possible that hypozincaemia caused by chronic Frusemide administration may lead to hyperglycemia in normal individuals and deteriorate the condition further in diabetics.…”

Section: Discussionmentioning

confidence: 99%

Effect of Frusemide on Serum and Urinary Zinc levels in Rabbits

Bhat¹,

Khan²

2015

JYP

View full text Add to dashboard Cite

Introduction:Zinc is an essential trace element playing a vital role in the maintenance of health. Frusemide, a loop diuretic, is known to deplete sodium, potassium, magnesium and calcium levels. But, very few reports exist on its effect on Zinc levels. Hence, this study was performed on rabbits to investigate the same in detail. Material & Methods: Healthy adult New Zealand White rabbits (n=6 per group) were treated with Normal saline (2 ml kg -1 ) and Frusemide (5, 10 or 15 mg kg -1 each) intraperitoneally. Their serum and urinary zinc levels were studied by Atomic Absorption Spectrophotometry. Analysis of serum Zinc levels was also done after dietary Zinc supplementation for 20 days. Results: A dose-dependent decrease in serum Zinc levels owing to increased urinary Zinc excretion was observed. Both the urinary volume and urinary Zinc concentration increased dose-dependently. The percent fall in serum Zinc occurred in proportion to the pre-treatment serum values. Administration of Zinc in the diet restored the serum Zinc levels to normal. Conclusion: Frusemide may be responsible for Zinc depletion. Supplementation of Zinc may help to prevent the same in patients on prolonged Frusemide therapy.

show abstract

“…Findings from several epidemiologic studies, however, attain no consensus on the effectiveness of zinc against prostate cancer, partly because of differences in experimental design, amount of zinc administered and methods in determining plasma/serum zinc status (Haase et al, 2008). Several studies showed that there are either no beneficiary effects of zinc or there are no potential adverse effects of dietary zinc on prostate cancer risk (Andersson et al, 1996;Kolonel, 1996;Vlajinac et al, 1997;West et al, 1991).…”

Section: Epidemiologic Studiesmentioning

confidence: 99%