Zinc supplementation for improving pregnancy and infant outcome

Mahomed, Kassam; Bhutta, Zulfiqar Ahmed; Middleton, Philippa

doi:10.1002/14651858.cd000230.pub3

Cited by 80 publications

(74 citation statements)

References 75 publications

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“…As with observational designs, the main weakness of the study was that unknown confounding factors capable of affecting birth outcomes were not adjusted for, such as zinc (49) and n-3 fatty acids (50). In addition, subjects were recruited only from one exclusive clinical hospital, so the characteristics of women visiting the clinic for prenatal care may have influenced the results.…”

Section: Effect Of Maternal Vitamin C and Vitamin E Status On Birth Omentioning

confidence: 99%

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Wang

Ren

Liao

et al. 2009

J Nutr Sci Vitaminol

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Summary Background: Emerging evidence indicates that maternal oxidative stress during pregnancy could impair fetal growth and that antioxidant vitamins (e.g. vitamins A, E and C) have a significant role in miantaining physiological processes of pregnancy and growth. Aims: To determine the concentrations of vitamins A, E, and C in pair-matched maternal and cord serum samples of neonate, and thus to investigate the relationship between maternal serum levels of these vitamins at delivery and birth outcomes. Methods: A total of 143 mother-neonate pairs were recruited into the cross-sectional descriptive study. Demographic information was investigated by questionnaire. After delivery, both cord and maternal blood were collected for quantification of serum levels of vitamins A, E and C by HPLC. Results: Maternal serum levels of vitamins A and E were significantly higher than those in cord serum. In contrast, vitamin C level in cord serum was significantly higher than that in maternal serum. Further, we found that maternal vitamin A status was significantly correlated to both birth weight ( r ϭ 0.19, p ϭ 0.0419) and birth height ( r ϭ 0.21, p ϭ 0.0311), and these were manifested by these findings: (i) per 250.2 g reduction in birth weight concomitant with 1 mol/L increase in maternal serum vitamin A level ( p Ͻ 0.01; 95% CI: 56.9-451.5); and (ii) per 1% increase in the ratio of serum vitamin A level of neonate to mother concomitant with 0.8 cm increase in birth height ( p ϭ 0.049; 95% CI: 0.004-1.639). Conclusion: Maternal vitamin A, but not vitamins E and C, during pregnancy had a significant effect on birth outcomes. Further studies are necessary to investigate the role of these antioxidant vitamins in fetal growth at various gestation stages.

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Section: Effect Of Maternal Vitamin C and Vitamin E Status On Birth Omentioning

confidence: 99%

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Wang

Ren

Liao

et al. 2009

J Nutr Sci Vitaminol

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“…Major problems associated with zinc deficiency include growth retardation, delayed immune system development, cognitive impairment, impaired glucose tolerance, low birth weight, congenital malformations, pregnancy-induced hypertension and increased risk of abortion, miscarriage, stillbirths, preterm labour, postpartum hemorrhage and prolonged labor [1,3,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of zinc deficiency and its association with dietary, serum albumin and intestinal parasitic infection among pregnant women attending antenatal care at the University of Gondar Hospital, Gondar, Northwest Ethiopia

et al. 2015

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Prevalence of zinc deficiency and its association with dietary, serum albumin and intestinal parasitic infection among pregnant women attending antenatal care at the University of Gondar Hospital, Gondar, Northwest Ethiopia Conclusion: Zinc deficiency is of public health concern in the study area. To combat the problems, nutrition education to increase knowledge as well as practices concerning the consumption of zinc rich foods and optimal dietary diversity, use of home based phytate reduction techniques and agricultural based approaches should be considered.

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“…The Cochrane review on zinc supplementation in pregnancy by Mahomed et al included 17 trials involving over 9000 women and their babies [18]. There was a significant, although small, reduction in preterm births based on 13 RCTs and 6854 women (RR: 0.86; 95% CI: 0.76-0.98) (FigurE 2).…”

Section: Zincmentioning

confidence: 98%