2019
DOI: 10.1101/616201
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Abstract: Zinc is a key component of proteins, including interaction with varying pancreatic hormones, including insulin and amylin. Zinc is key in insulin crystallinity in ZnT8 knock-out mice models, although the dietary role of zinc restriction over both energetic metabolism and ß-pancreatic hormonemia and morphology remained unexplored. We aimed to test whether dietary zinc restriction on swiss male mice would impact over endocrine pancreas and metabolic phenotype. We evaluated the role of dietary zinc restriction on… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2020
2020
2020
2020

Publication Types

Select...
1

Relationship

1
0

Authors

Journals

citations
Cited by 1 publication
(2 citation statements)
references
References 66 publications
0
2
0
Order By: Relevance
“…The animals (n=6-8 animals/group), immediately after weaning, were divided into two groups that received regular or zinc deficient diets, and maintained with the assigned diets throughout the experiment. Control group was exclusively fed with the AIN-93 modified chow (with casein replaced by hen egg white solids; Salto’s LTDA), formulated with either regular mineral mix (AIN-93G-MX) or zinc-deficient mineral mix formulated without added zinc salts (AIN-93G-MX-ZnDef) as previously reported (Sisnande et al, 2020).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The animals (n=6-8 animals/group), immediately after weaning, were divided into two groups that received regular or zinc deficient diets, and maintained with the assigned diets throughout the experiment. Control group was exclusively fed with the AIN-93 modified chow (with casein replaced by hen egg white solids; Salto’s LTDA), formulated with either regular mineral mix (AIN-93G-MX) or zinc-deficient mineral mix formulated without added zinc salts (AIN-93G-MX-ZnDef) as previously reported (Sisnande et al, 2020).…”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, zinc acts also as a cofactor of tyrosine kinases, enzymes responsible to activate IGF-1 receptor (Wilson et al, 2012). A recent study of our group revealed that zinc restriction produces selective degeneration of the endocrine pancreas in mice (SISNANDE et al, 2020). In the central nervous system (CNS), zinc is an essential micronutrient for the development of memory and learning processes, as well as mediating synaptic plasticity (Hagmeyer et al, 2015).…”
Section: Introductionmentioning
confidence: 99%