Zinc picolinate supplementation decreases oxidative stress in rainbow trout (Oncorhynchus mykiss)

Küçükbay, Zehra; Yazlak, H.; Şahin, Nurhan; Tuzcu, Mehmet; Çakmak, Mehmet Nuri; Gürdoğan, Fuat; Juturu, Vijaya; Şahin, Kazım

doi:10.1016/j.aquaculture.2006.03.005

Cited by 67 publications

(42 citation statements)

References 35 publications

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“…Kucukbay et al (2006) reported that supplemental Zn in the diet decreases serum and tissue lipid peroxidation in rainbow trout. The CuZn-Sod gene expression pattern decreased markedly in Zn-supplemented fishes when compared to Cd-exposed animals in liver and was similar to control animals in ovaries.…”

Section: Discussionmentioning

confidence: 98%

Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio

Bannı

Chouchene²,

Saïd³

et al. 2011

Biometals

107

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The present study was designed to elucidate the protective effect mechanism of Zinc (Zn) and Selenium (Se) on cadmium (Cd)-induced oxidative stress in zebrafish. For this purpose we investigate the response of oxidative stress markers, metallothionein accumulation and gene expression in liver and ovary of female zebrafish exposed to 0,4 mg/l Cd in water and supplemented with Zn (5 mg kg(-1)) and/or Se (2 mg kg(-1)) for 21 days in their diet. Liver and ovary Cd uptake was evaluated after the exposure period. Cd exposure significantly inhibited the antioxidant enzyme activities termed as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) and caused a pronounced malondialdehyde (MDA) accumulation in both organs. Co-administration of Zn and Se reversed the Cd-induced toxicity in liver and ovary measured as MDA accumulation. Interestingly, gene expression patterns of Cat, CuZnSod and Gpx were up-regulated when related enzymatic activities were altered. Zebrafish metallothionein transcripts (zMt) significantly decreased in tissues of fish supplemented with Zn and/or Se when compared to Cd-exposed fish. Our data would suggest that Zn and Se protective mechanism against Cd-induced oxidative stress is more depending on the correction of the proteins biological activities rather than on the transcriptional level of related genes.

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Section: Discussionmentioning

confidence: 98%

Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio

Bannı

Chouchene²,

Saïd³

et al. 2011

Biometals

107

View full text Add to dashboard Cite

show abstract

“…Zinc also serves as a functional cofactor for more than 200 metalloenzymes, such as superoxide dismutase, RNA polymerase, alkaline phosphatase, alcohol dehydrogenase, and carbonic anhydrase (Kucukbay et al 2006;Fountoulaki et al 2010;Luo et al 2011;Liang et al 2012;Lin et al 2013). The importance of Zn in the antioxidant protection has been also illustrated in many aquatic organisms (Huang et al 2015;Feng et al 2011;Trevisan et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

et al. 2017

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This study investigated the effect of dietary Zn levels on growth performance, feed utilization, and hematological parameters of juvenile Siberian sturgeon (Acipenser baerii, Brandt 1869). The five semipurified diets were formulated by adding 0, 5, 10, 20, and 40 mg Zn kg -1 diet in the form of zinc sulfate (ZnSO 4 ) to provide the actual dietary value of 14.7, 20.8, 27.3, 37.7, and 46.4 Zn kg -1 diet, respectively. The results showed that dietary Zn elevating level significantly improved the growth and feed utilization of the fish (p \ 0.05), but not the hepatosomatic index (p [ 0.05). Erythrocyte number, hemoglobin concentration, and hematocrit were increased with raising dietary Zn level (p \ 0.05), whereas a regular trend was not observed in blood indices, including MCV, MCH, and MCHC. A significant increase was also found in the leucocyte number followed by their differential counts, except for eosinophil percentage. The broken line regression model indicated optimal dietary Zn level for growth maximization of fish was estimated to be 29.15 mg Zn kg -1 diet. In spite of well correlation with dietary Zn level, no break point was observed to estimate the juvenile Siberian sturgeon requirement based on the erythrocyte numbers.

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“…However, most studies on oxidative stress in fish have focused on natural and anthropogenic toxicological aspects, such as intrinsic factors in the fish itself, environmental factors and xenobiotics (Winston and Di Giulio 1991). Recent research has begun to pay attention to the roles of nutrient factors in the antioxidant system of fish, and a few nutrients have been preliminarily studied, including energy diets such as protein (Lopez-Bote et al 2001), lipids (Alvarez et al 1998), fatty acids (Stéphan et al 1995) and digestible carbohydrate (Rueda-Jassoa et al 2004); vitamins such as vitamin E (George et al 2000), vitamin C (Dabrowski et al 2004), vitamin A (Fontagné et al 2006), pyridoxine (Huang et al 2005) and thiamin (Huang et al 2007); minerals such as selenium (Lin and Shiau 2005), iron (Andersen et al 1998) and zinc (Kucukbay et al 2006). However, little research (but see Woodward 1983) concerns the role of riboflavin in antioxidant defense systems in fish.…”

mentioning

confidence: 98%

Effects of dietary riboflavin levels on antioxidant defense of the juvenile grouper Epinephelus coioides

Huang

Liu

et al. 2008

Fish Physiol Biochem

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This study was conducted to evaluate the effects of dietary riboflavin on antioxidant defense in the juvenile grouper Epinephelus coioides. Graded levels of riboflavin (0.9, 1.6, 4.4, 6.7, 12.9 and 19.4 mg kg(-1) dry diet) were fed to grouper juveniles (mean weight: 14.90 +/- 0.46 g) for 12 weeks. Higher levels of liver thiobarbituric acid reactive substances (TBARS) content were observed in grouper fed low doses (0.9 and 1.6 mg kg(-1) diet) of riboflavin. Both liver glutathione reductase (GR) activity and its activation coefficient (GR-AC) poorly responded to riboflavin deficiency. In addition, other indices of the glutathione-dependent defense system, including the activities of glutathione peroxidase (GSH-PX) and glutathione-S-transferase (GST), and the content of glutathione (GSH), were also non-significantly affected by dietary riboflavin levels. However, the activities of liver superoxide dismutase (SOD) and catalase (CAT) were significantly lower in fish fed 0.9 mg kg(-1) diet, with a positive correlation between the different groups. In conclusion, the present study indicated that the juvenile grouper fed the riboflavin-unsupplemented diet was susceptible to lipid peroxidation (LPO), with lower SOD and CAT activities in the liver. However, the glutathione-dependent defense system of grouper was not affected by dietary riboflavin levels.

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Zinc picolinate supplementation decreases oxidative stress in rainbow trout (Oncorhynchus mykiss)

Cited by 67 publications

References 35 publications

Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio

Mechanisms underlying the protective effect of zinc and selenium against cadmium-induced oxidative stress in zebrafish Danio rerio

Dietary zinc requirement of Siberian sturgeon (Acipenser baerii, Brandt 1869) juveniles, based on the growth performance and blood parameters

Effects of dietary riboflavin levels on antioxidant defense of the juvenile grouper Epinephelus coioides

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