Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies

Sathishkumar, Palanivel; Li, Zhaofa; Govindan, R.; Jayakumar, R.; Wang, Chaoyang; Gu, Feng

doi:10.1016/j.apsusc.2020.147741

Cited by 91 publications

(39 citation statements)

References 67 publications

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“…Peaks at 1263 cm −1 and 1013 cm −1 are appearing due to the stretching vibrations of C–O–C and C = C–O bonds, respectively (Catauro et al 2015 ). The FTIR spectrum of QT-ZnO-BCD NPs showed peak in the region of 3500–3300 cm −1 which is due to the -OH group (Sathishkumar et al 2021 ) while broad peak at 1636 cm −1 indicated the merging of peaks of quercetin C = C aromatic bonds and beta-cyclodextrin H–O–H bending vibrations. Suppression of peaks was observed at 1554 cm −1 , 1269 cm −1 and 1031 cm −1 which are attributed to C = C, C–O–C and C = C–O bonds, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Suppression of peaks was observed at 1554 cm −1 , 1269 cm −1 and 1031 cm −1 which are attributed to C = C, C–O–C and C = C–O bonds, respectively. Major absorption peak in the region of 550–400 cm −1 is attributed to the Zn–O bond (Sathishkumar et al 2021 ). The peak shifting and suppression indicated the interaction of functional groups of quercetin with ZnO-BCD NPs and formation of QT-ZnO-BCD NPs (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The data are representative of several experiments performed in duplicate and expressed as the mean ± standard error, where (*) represent when P ≤ 0.05 loaded with β-cyclodextrin and five drugs (Quericitin, Ceftrixon, Naranjin, Amphotericin B and Ampicillin). These formulations were characterized using a range of techniques such as zeta potential analysis and zeta sizer, UV-visible, FTIR, AFM as previously described (Gagoś and Arczewska 2010;Ethiraj et al 2014;Catauro et al 2015;Liu et al 2015;Diaz-Uribe et al 2016;Kalaiselvi et al 2016;Kavitha et al 2017;Mushtaq et al 2017;Reddy et al 2020;Kadam et al 2020;Kaur et al 2020;Yang et al 2020;Sathishkumar et al 2021). ZnO-NPs were synthesized using direct precipitation method and upon successful formation coupled with β-cycldextrin.…”

Section: Discussionmentioning

confidence: 99%

“…4b). Absorption peaks is attributed to the Zn-O bond (Sathishkumar et al 2021). The peak shifting and suppression indicated the interaction of functional groups of quercetin with ZnO-BCD NPs and formation of QT-ZnO-BCD NPs (Fig.…”

Section: Ftir Analysismentioning

confidence: 98%

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Zinc oxide nanoparticles conjugated with clinically-approved medicines as potential antibacterial molecules

et al. 2021

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At present, antibiotic resistance is one of the most pressing issues in healthcare globally. The development of new medicine for clinical applications is significantly less than the emergence of multiple drug-resistant bacteria, thus modification of existing medicines is a useful avenue. Among several approaches, nanomedicine is considered of potential therapeutic value. Herein, we have synthesized Zinc oxide nanoparticles (ZnO-NPs) conjugated with clinically-approved drugs (Quercetin, Ceftriaxone, Ampicillin, Naringin and Amphotericin B) with the aim to evaluate their antibacterial activity against several Gram-positive (Methicillin resistant Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes) and Gram-negative (Escherichia coli K1, Serratia marcescens and Pseudomonas aeruginosa) bacteria. The nanoparticles and their drug conjugates were characterized using UV-visible spectrophotometry, dynamic light scattering, Fourier transform infrared spectroscopy and atomic force microscopy. Antibacterial activity was performed by dilution colony forming unit method and finally 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays were performed to determine their cytotoxic effects against human cell lines. ZnO-NPs revealed maxima surface plasmon resonance band at 374 and after conjugation with beta-cyclodextrin at 379 nm, polydispersity with size in range of 25–45 nm with pointed shaped morphology. When conjugated with ZnO-NPs, drug efficacy against MDR bacteria was enhanced significantly. In particular, Ceftriaxone- and Ampicillin-conjugated ZnO-NPs exhibited potent antibacterial effects. Conversely, ZnO-NPs and drugs conjugated NPs showed negligible cytotoxicity against human cell lines except Amphotericin B (57% host cell death) and Amphotericin B-conjugated with ZnO-NPs (37% host cell death). In conclusion, the results revealed that drugs loaded on ZnO-NPs offer a promising approach to combat increasingly resistant bacterial infections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Ftir Analysismentioning

confidence: 98%

See 2 more Smart Citations

Zinc oxide nanoparticles conjugated with clinically-approved medicines as potential antibacterial molecules

et al. 2021

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“…However, the toxicity and deformation of nanoparticles in the human body must be carefully considered. Many synthetic nanoparticles, such as silica nanoparticles [ 4 , 5 , 6 ] and metal oxides [ 7 , 8 ], can successfully be used as drug carriers, while natural-derived nanoparticles are more potential due to their biocompatibility, biodegradability, and non-toxicity.…”

Section: Introductionmentioning

confidence: 99%

A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

2021

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Due to their biocompatibility, biodegradability, and non-toxicity, lignocellulosic-derived nanoparticles are very potential materials for drug carriers in drug delivery applications. There are three main lignocellulosic-derived nanoparticles discussed in this review. First, lignin nanoparticles (LNPs) are an amphiphilic nanoparticle which has versatile interactions toward hydrophilic or hydrophobic drugs. The synthesis methods of LNPs play an important role in this amphiphilic characteristic. Second, xylan nanoparticles (XNPs) are a hemicellulose-derived nanoparticle, where additional pretreatment is needed to obtain a high purity xylan before the synthesis of XNPs. This process is quite long and challenging, but XNPs have a lot of potential as a drug carrier due to their stronger interactions with various drugs. Third, cellulose nanocrystals (CNCs) are a widely exploited nanoparticle, especially in drug delivery applications. CNCs have low cytotoxicity, therefore they are suitable for use as a drug carrier. The research possibilities for these three nanoparticles are still wide and there is potential in drug delivery applications, especially for enhancing their characteristics with further surface modifications adjusted to the drugs.

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Antioxidant activity and controlled‐release feature of Quercetin loaded amines‐functionalized magnetically porous cellulose

Saputra

Apriansyah

Puspitasari

et al. 2021

J of Applied Polymer Sci

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Loading of quercetin onto drug cargo is still progressively studied to not only improve its solubility but also control the release behavior for improving therapeutics efficacy. In this present study, we successfully prepared drug cargo based magnetically porous cellulose (PC) functionalized by amine‐based alkoxysilane (MPC−NH2) for effectively carrying and sustainably delivering quercetin. The PC derived from oil palm empty fruit bunches provides high loading capacity reaching 344.48 ± 5.69 mg/g with loading effectiveness of 67.02 ± 1.11%. Surface modification of PC surfaces by Fe3O4 nanoparticles and aminosilane compounds not only enhances the quercetin loading effectiveness to 80.83 ± 1.10% but also controls the quercetin release behavior either at artificial gastric or physiological condition. The kinetic release study elaborates that anomalous transport is mainly involved during release of quercetin under physiological condition, but the Fickian diffusion plays the role at artificial gastric condition. The kinetic release rate of quercetin calculated following Higuchi model indicates that the Que@MPC−NH2 has slower release rate compared to another drug carrier. Additionally, the antioxidant activity of quercetin is significantly improved after being loaded onto MPC−NH2. Finally, we recapitulate that the loading of quercetin within MPC−NH2 is a powerful strategy for improving loading capacity, drug‐release ability, and antioxidant activity.

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Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies

Cited by 91 publications

References 67 publications

Zinc oxide nanoparticles conjugated with clinically-approved medicines as potential antibacterial molecules

Zinc oxide nanoparticles conjugated with clinically-approved medicines as potential antibacterial molecules

A Review of Lignocellulosic-Derived Nanoparticles for Drug Delivery Applications: Lignin Nanoparticles, Xylan Nanoparticles, and Cellulose Nanocrystals

Antioxidant activity and controlled‐release feature of Quercetin loaded amines‐functionalized magnetically porous cellulose

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