Zinc-modified phosphate-based glass micro-filler improves Candida albicans resistance of auto-polymerized acrylic resin without altering mechanical performance

Lee, Myung-Jin; Kim, Minji; Mangal, Utkarsh; Seo, Ji‐Young; Kwon, Jae‐Sung; Choi, Sung‐Hwan

doi:10.1038/s41598-022-24172-y

Cited by 11 publications

(9 citation statements)

References 44 publications

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“…However, the OD value of S. mutans decreased with increasing Sr-PBG content in the composite resin. These results are similar to those obtained with silver-, zinc-, and gallium-doped bioactive glass additives 25 , 37 , 38 . Strontium is a major mineral that acts as an antimicrobial agent against S. mutans 20 .…”

Section: Discussionsupporting

confidence: 88%

Mechanical properties and sustainable bacterial resistance effect of strontium-modified phosphate-based glass microfiller in dental composite resins

Go,

Lee,

Seo

et al. 2023

Sci Rep

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Dental composite resins are widely used in dental restorations. However, their clinical application is limited by the occurrence of secondary caries. Strontium-modified phosphate-based glass (Sr-PBG) is a material known to have a sustainable bacterial resistance effect. The mechanical properties (in particular, flexural strength, modulus of elasticity, and hardness) of dental materials determine their function. Therefore, this study aimed to investigate the mechanical and ion-releasing properties as well as the sustainable bacterial resistance effect of bioactive resin composites containing Sr-PBG. The data were analyzed by ANOVA and Tuckey’s tests (p < 0.05). We incorporated a Sr-PBG microfiller at 3, 6, and 9 wt.% concentrations into a commercially available composite resin and investigated the mechanical properties (flexural strength, elastic modulus, and micro hardness), ion release characteristics, and color of the resultant resins. In addition, we examined the antibacterial effects of the composite resins against Streptococcus mutans (S. mutans). The mechanical properties of the Sr-PBG groups differed only slightly from those of the control group (p > 0.05). However, the optical density at 600 nm of S. mutans incubated on the experimental group was significantly lower compared to that observed with the control (p < 0.05) both before and after thermocycling between 5 and 55 ℃ for 850 cycles (dwell time: 45 s). Therefore, strontium-modified resin materials exhibited a sustainable bacterial resistance effect in vitro while maintaining some of the mechanical properties of ordinary acrylic resins.

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Section: Discussionsupporting

confidence: 88%

Mechanical properties and sustainable bacterial resistance effect of strontium-modified phosphate-based glass microfiller in dental composite resins

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Lee,

Seo

et al. 2023

Sci Rep

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“… 32 NMBG was applied in the compounding of organic materials to enhance their properties. 33 , 34 Studies have once shown that NMBG scaffolds can support cell adhesion, proliferation, and differentiation in vitro. When in contact with body fluids in vivo, NMBG slowly released internally loaded drugs, further enhancing its biological activity.…”

Section: Resultsmentioning

confidence: 99%

Scaffold Adhering to Peptide-Based Biomimetic Extracellular Matrix Composite Nanobioglass Promotes the Proliferation and Migration of Skin Fibroblasts Through the GSK-3β/β-Catenin Signaling Axis

Cao,

Wang,

Sun

et al. 2024

IJN

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Introduction Nano-mesoporous bioactive glass and RGD peptide-coated collagen membranes have great potential in wound healing. However, the application of their compound has not been further studied. Our purpose is to prepare a novel bioactive collagen scaffold containing both NMBG stent and adhesion peptides (BM), which then proves its promising prospect the assessment of physical properties, biocompatibility, GSK-3β/β-catenin signaling axis and toxicological effects. Methods The structural and morphological changes of BM were analyzed using scanning electron microscopy (SEM) and Energy Dispersive Spectroscopy (EDS). In vivo, wound healing of BM was assessed in SD rats through dynamic monitoring and calculation of wound healing rate. Immunohistofluorescence (IHF), H&E, and Masson staining were utilized; in vitro, primary cell culture, and a variety of assays including CCK-8, Transwell, Scratch, Immunocytofluorescence (ICF), and Western blot (WB) were performed, both for morphology and molecular analysis. Results and Discussion Preparation of BM involved attaching NMBG to RGD-exposed collagen while avoiding the use of toxic chemical reagents. BM exhibited a distinctive superficial morphology with increased Si content, indicating successful NMBG attachment. In vivo studies on SD rats demonstrated the superior wound healing capability of BM, as evidenced by accelerated wound closure, thicker epithelial layers, and enhanced collagen deposition compared to the NC group. Additionally, BM promoted skin fibroblast migration and proliferation, possibly through activation of the GSK-3β/β-catenin signaling axis, which was crucial for tissue regeneration. This study underscored the potential of BM as an effective wound-healing dressing. Conclusion A new method for synthesizing ECM-like membranes has been developed using nano-mesoporous bioactive glass and collagen-derived peptides. This approach enhances the bioactivity of biomaterials through surface functionalization and growth factor-free therapy.

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“…Antibacterial properties can also be obtained by the addition of, e.g., AgVO 3 [ 14 ], mesoporous silica nanoparticles [ 28 ], zinc-modified phosphate-based glass microfiller [ 29 ], and ZnO [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…If the amount of unsilanized glass added is increased, a decrease in flexural strength can be observed [ 29 ]. For this reason, the measurable benefit of using half of the glass in the silanized form is the improvement of the mechanical properties of the new sample (Agarwal) [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Bioactive Glass-Enhanced Resins: A New Denture Base Material

Raszewski¹,

Chojnacka

Mikulewicz

et al. 2023

Materials

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Background: The creation of the denture base material with bioactive properties that releases ions and produces hydroxyapatite. Methods: Acrylic resins were modified by the addition of 20% of four types of bioactive glasses by mixing with powders. Samples were subjected to flexural strength (1, 60 days), sorption and solubility (7 days), and ion release at pH 4 and pH 7 for 42 days. Hydroxyapatite layer formation was measured using infrared. Results: Biomin F glass-containing samples release fluoride ions for a period of 42 days (pH = 4; Ca = 0.62 ± 0.09; P = 30.47 ± 4.35; Si = 22.9 ± 3.44; F = 3.1 ± 0.47 [mg/L]). The Biomin C (contained in the acrylic resin releases (pH = 4; Ca = 41.23 ± 6.19; P = 26.43 ± 3.96; Si = 33.63 ± 5.04 [mg/L]) ions for the same period of time. All samples have a flexural strength greater than 65 MPa after 60 days. Conclusion: The addition of partially silanized bioactive glasses allows for obtaining a material that releases ions over a longer period of time. Clinical significance: This type of material could be used as a denture base material, helping to preserve oral health by preventing the demineralization of the residual dentition through the release of appropriate ions that serve as substrates for hydroxyapatite formation.

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Zinc-modified phosphate-based glass micro-filler improves Candida albicans resistance of auto-polymerized acrylic resin without altering mechanical performance

Cited by 11 publications

References 44 publications

Mechanical properties and sustainable bacterial resistance effect of strontium-modified phosphate-based glass microfiller in dental composite resins

Mechanical properties and sustainable bacterial resistance effect of strontium-modified phosphate-based glass microfiller in dental composite resins

Scaffold Adhering to Peptide-Based Biomimetic Extracellular Matrix Composite Nanobioglass Promotes the Proliferation and Migration of Skin Fibroblasts Through the GSK-3β/β-Catenin Signaling Axis

Bioactive Glass-Enhanced Resins: A New Denture Base Material

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