Zinc ion‐induced formation of hierarchical N‐succinyl chitosan film

Wang, Hongjiao; Liu, Shunli; Zhang, Aokai; Li, Kewen; Yao, Fang

doi:10.1002/app.44664

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Their popularity is given due to its good biocompatibility, possibilities for modifications, low cost and easy to prepare protocols. Based on several studies, zinc combined with chitosan has several applications such as: sensors [ 75 ], micronutrient nanocarrier [ 76 ] and nanocomposite coatings [ 77 , 78 , 79 ]. In our pilot experiment, zinc ions were incorporated into the CS NPs structure for a purpose of NP structure stabilization and passive targeting.…”

Section: Discussionmentioning

confidence: 99%

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

et al. 2017

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This work investigated the preparation of chitosan nanoparticles used as carriers for doxorubicin for targeted cancer delivery. Prepared nanocarriers were stabilized and functionalized via zinc ions incorporated into the chitosan nanoparticle backbone. We took the advantage of high expression of sarcosine in the prostate cancer cells. The prostate cancer targeting was mediated by the AntiSar antibodies decorated surface of the nanocage. Formation of the chitosan nanoparticles was determined using a ninhydrin assay and differential pulse voltammetry. Obtained results showed the strong effect of tripolyphosphine on the nanoparticle formation. The zinc ions affected strong chitosan backbone coiling both in inner and outer chitosan nanoparticle structure. Zinc electrochemical signal depended on the level of the complex formation and the potential shift from −960 to −950 mV. Formed complex is suitable for doxorubicin delivery. It was observed the 20% entrapment efficiency of doxorubicin and strong dependence of drug release after 120 min in the blood environment. The functionality of the designed nanotransporter was proven. The purposed determination showed linear dependence in the concentration range of Anti-sarcosine IgG labeled gold nanoparticles from 0 to 1000 µg/mL and the regression equation was found to be y = 3.8x − 66.7 and R2 = 0.99. Performed ELISA confirmed the ability of Anti-sarcosine IgG labeled chitosan nanoparticles with loaded doxorubicin to bind to the sarcosine molecule. Observed hemolytic activity of the nanotransporter was 40%. Inhibition activity of our proposed nanotransporter was evaluated to be 0% on the experimental model of S. cerevisiae. Anti-sarcosine IgG labeled chitosan nanoparticles, with loaded doxorubicin stabilized by Zn ions, are a perspective type of nanocarrier for targeted drug therapy managed by specific interaction with sarcosine and metallothionein for prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

et al. 2017

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“…The appeal of biodegradable food packaging films has gradually grown among researchers [ 2 ]. Many polysaccharides including starch, cellulose, and chitin have undergone extensive investigation [ 3 , 4 , 5 ]. Chitosan is available from fungi, crustaceans, and plants [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Sodium Trimetaphosphate on Chitosan-Methylcellulose Composite Films: Physicochemical Properties and Food Packaging Application

Wang

Liao

et al. 2019

Polymers

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Environmentally friendly food packaging currently attracts much interest. Sodium trimetaphosphate (STMP) finds specialized applications in food, but it is rarely used as a crosslinking agent. In this study, STMP was used as a crosslinking agent to prepare chitosan/methylcellulose composite films. Both antibacterial and physicochemical properties of the composite film were improved by crosslinking with STMP. The crosslinked films, with good antibacterial activity (~99%), had increased tensile strength, a higher elongation at break, a lower swelling ratio and solubility, and a lower enzymatic degradation than the non-crosslinked films. Furthermore, the crosslinked films showed an excellent preservative effect on fresh-cut wax gourd after three days at room temperature. The obtained films crosslinked by STMP can be potentially applied to the food industry, such as food functional packaging, providing a novel alternative to traditional plastic packages.

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“…In a chemical speak, chitosan is an unbranched chain of β (14)-2-acetoamido-2deoxy-D-glucose which exerts unique chemical properties like ability to make complexes with cations. Ionic forms of zinc, copper, nickel, rhenium, iron, cobalt can be introduced as metallic cations firmly binding to or onto chitosan matrix [29][30][31][32][33][34][35][36]. There is also significant affinity of some drugs to chitosan and interactions between chitosan as an carrier and methotrexate (amethopterin), dipeptidyl peptidase-IV inhibitor, ibuprofen ((αS)-α-methyl-4-(2-methylpropyl)-benzeneacetic acid), scutellarin (7-(β-Dglucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), paclitatex (Taxol) are known [37][38][39][40][41].…”

Section: Membranes For a Template Imprintingmentioning

confidence: 99%

Sensors Based on Molecularly Imprinted Polymers

Pohanka¹

2017

International Journal of Electrochemical Science

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Molecularly Imprinted Polymer (MIP) is a polymer having imprinted a molecule on its surface and the surface is able to interact with the molecule chemically equivalent or at least resembling the template molecule. A matrix based on MIP has broad technical applicability in various disciplines like chemical separation, medical use or in analytical chemistry. This paper is devoted to the survey and discussion of MIP use in sensors construction. Materials and analytes are written in details and actual studies in this field are discussed.

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Zinc ion‐induced formation of hierarchical N‐succinyl chitosan film

Cited by 5 publications

References 39 publications

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

Zinc-Modified Nanotransporter of Doxorubicin for Targeted Prostate Cancer Delivery

Effect of Sodium Trimetaphosphate on Chitosan-Methylcellulose Composite Films: Physicochemical Properties and Food Packaging Application

Sensors Based on Molecularly Imprinted Polymers

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