Zinc(II) phthalocyanine substituted by sulfonamide derivative: Photophysical and photochemical properties

Şahal, Hakan

doi:10.1016/j.molstruc.2022.134275

“…Furthermore, copper (II) analogous complexes have been discovered to be less cytotoxic than those of zinc (II) complexes [157]. The higher cytotoxicity of the zinc (II) complexes may be due to their photochemical properties [158], as a significant fluorescence increase was observed by interaction with calf thymus DNA [159]. As a result, there is a good correlation between cytotoxicity in anti-proliferative action and cellular metal uptake.…”

Section: Cuzn In Schiff-based and Schiff-paired Structuresmentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…Furthermore, copper(II) analogous complexes have been discovered to be less cytotoxic than those of zinc(II) complexes [ 158 ]. The higher cytotoxicity of the zinc(II) complexes may be due to their photochemical properties [ 159 ], as a significant fluorescence increase was observed by interaction with calf thymus DNA [ 160 ]. As a result, there is a good correlation between cytotoxicity in anti-proliferative action and cellular metal uptake.…”

Section: Copper Zinc and Cuzn In Organic Solvent Formation Structuresmentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi

¹

,

Miskon

²

2023

Molecules

16

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

show abstract

Synthesis, photophysical, and photochemical properties of functional molecules based on a novel zinc(II) phthalocyanine-1,8-naphthalimide skeleton

Liu

¹

,

Han

²

,

Xu

³

et al. 2023

Journal of Molecular Structure

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Zinc(II) phthalocyanine substituted by sulfonamide derivative: Photophysical and photochemical properties

Cited by 3 publications

References 74 publications

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Synthesis, photophysical, and photochemical properties of functional molecules based on a novel zinc(II) phthalocyanine-1,8-naphthalimide skeleton

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