Zinc finger C3H1-type containing serves as a novel prognostic biomarker in human pan-cancer

Liang, Wenken; Chen, Wei; Wei, Jianfen; Yao, Hongbing; Shi, Jinjin; Hou, Xianliang; Deng, Yecheng; Ou, Minglin

doi:10.1016/j.gene.2022.146251

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Considering multiple aspects of Zn finger protein signaling domains, they carry the potential to be developed as prognostic markers as well as therapeutic targets in prostate cancer [ 54 , 130 ].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, at the time of prostate cancer diagnoses, men with type II diabetes or pre-diabetes may require additional clinical support to adequately control blood sugar levels, to suppress diabetes-associated Zn urinary excretion which may otherwise further assist in prostate cancer progression. Meanwhile, it is considered that aspects of ZF protein signaling domains, may carry the potential to be developed as prognostic markers as well as therapeutic targets in prostate cancer [ 54 , 130 ].…”

Section: Discussion and Commentarymentioning

confidence: 99%

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Zinc in Prostate Health and Disease: A Mini Review

Karunasinghe

2022

Biomedicines

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Introduction-With the high global prevalence of prostate cancer and associated mortalities, it is important to enhance current clinical practices for better prostate cancer outcomes. The current review is towards understanding the value of Zn towards this mission. Method-General information on Zn in biology and multiple aspects of Zn involvement in prostate health and disease were referred to in PubMed. Results-The most influential feature of Zn towards prostate health is its ability to retain sufficient citrate levels for a healthy prostate. Zn deficiencies were recorded in serum, hair, and prostate tissue of men with prostate cancer compared to non-cancer controls. Zn gut absorption, albumin binding, and storage compete with various factors. There are multiple associations of Zn cellular influx and efflux transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling with prostate cancer outcomes. Such Zn marker variations associated with prostate cancer recorded from biological matrices may improve algorithms for prostate cancer screening, prognosis, and management when coupled with standard clinical practices. Discussion-The influence of Zn in prostatic health and disease is multidimensional, therefore more personalized Zn requirements may be beneficial. Several opportunities exist to utilize and improve understanding of Zn associations with prostate health and disease.

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Section: Resultsmentioning

confidence: 99%

Section: Discussion and Commentarymentioning

confidence: 99%

Zinc in Prostate Health and Disease: A Mini Review

Karunasinghe

2022

Biomedicines

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“…Consequently, a wealth of sequencing and clinical data for different types of cancer is now available (5). By using public databases such as The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), bioinformatics can be used to perform pan-cancer analysis at the DNA, RNA, protein and epigenetic level to reveal the roles of genes in different cancers (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Multi‑dimensional analysis reveals NCKAP5L is a promising biomarker for the diagnosis and prognosis of human cancers, especially colorectal cancer

Sha,

Liang,

et al. 2023

Oncol Lett

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The Nck-associated protein 5-like (NCKAP5L) gene, also known as Cep169, is associated with certain cancers. However, the diagnosis and prognosis value of NCKAP5L in several types of human cancer, including colorectal cancer, is not fully understood. In the present study, a comprehensive pan-cancer analysis of NCKAP5L was performed using several approaches, including gene expression and alteration, protein phosphorylation, immune infiltration, survival prognosis analyses and gene enrichment using the following: The University of California Santa Cruz Genome Browser Human Dec. 2013 (GRCh38/hg38) Assembly, Tumor Immune Estimation Resource (version 2), Human Protein Atlas, Gene Expression Profiling Interactive Analysis (version 2), University of Alabama at Birmingham Cancer Data Analysis portal, the Kaplan-Meier Plotter, cBioportal, Search Tool for the Retrieval of Interacting Genes/Proteins, Jvenn and the Metascape server. The role of NCKAP5L in colorectal cancer was further assessed by reverse transcription-quantitative PCR. The results demonstrated that NCKAP5L was upregulated in the majority of cancer types, including colorectal cancer. The high expression of NCKAP5L was significantly correlated with patient survival prognosis and immune infiltration of cancer-associated fibroblasts in numerous types of cancer, including colorectal cancer. Furthermore, Gene Ontology analysis identified that NCKAP5L may serve an important role in metabolic and cellular processes in human cancers. In summary, the data from the present study demonstrate that NCKAP5L is a potential tumor biomarker for the diagnosis and prognosis of human cancers, especially colorectal cancer.

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Expression Analysis of VPS72 and Associated Biological Behaviors in Colon Cancer

Cao,

Zhang,

Xie

et al. 2024

IJGM

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Background VPS72 is highly expressed in hepatocellular carcinoma and prostate cancer, participating in various cellular processes such as gene transcription, replication, DNA repair, maintenance of genome integrity, and cancer progression. However, its role in colorectal cancer remains unknown. Methods Bioinformatic methods were used to analyze gene expression, correlation and patient survival. Western blotting, colony formation assays and animal experiments were used to evaluate the function of VPS72 in colon cancer in vivo and in vitro. Results VPS72 was highly expressed in colon cancer tissues and correlated with poor overall survival ( P <0.05) and relapse free survival ( P <0.01). Furthermore, patients with III/IV clinical stage ( P <0.001), N1 nodal metastasis ( P <0.001) or N2 nodal metastasis ( P <0.05) status had poor overall survival. Further analysis showed that VPS72 is correlated with proliferation and EMT biomarkers. Western blotting, colony formation assays and animal experiments showed that VPS72 overexpression promoted colon cancer proliferation and EMT progress. Conclusion Our study found that VPS72 was correlated with poor overall survival in colon cancer patients, and high expressed level of VPS72 promoted colon cancer progression, indicating its role as a potential prognosis biomarker.

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Zinc finger C3H1-type containing serves as a novel prognostic biomarker in human pan-cancer

Cited by 4 publications

References 41 publications

Zinc in Prostate Health and Disease: A Mini Review

Zinc in Prostate Health and Disease: A Mini Review

Multi‑dimensional analysis reveals NCKAP5L is a promising biomarker for the diagnosis and prognosis of human cancers, especially colorectal cancer

Expression Analysis of VPS72 and Associated Biological Behaviors in Colon Cancer

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