Zinc dyshomeostasis in secretory compartments promotes tumor growth and invasion via cell autonomous and non-autonomous autophagy

Gao, Jiajia; Ma, Xuekai; Qu, Tao; Xiao, Guiran

doi:10.1080/27694127.2022.2062966

Autophagy Reports

2022

DOI: 10.1080/27694127.2022.2062966

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Zinc dyshomeostasis in secretory compartments promotes tumor growth and invasion via cell autonomous and non-autonomous autophagy

Jiajia Gao

Xuekai Ma

Tao Qu

et al.

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2024

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Matrix Metalloproteinases in Oral Cancer Pathogenesis and their Use in Therapy

Maurya,

Prasad,

Mukherjee

2024

ACAMC

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Matrix metalloproteinases (MMPs) are proteolytic enzymes that aid in extracellular matrix (ECM) remodeling. MMPs destroy the extracellular matrix, causing tumor growth and metastasis. MMPs are involved in the spread and metastasis of oral cancer. High levels of MMPs and oral squamous cell carcinoma have been linked to cancer prognosis. Modern medicine aims to prevent the illness from spreading through early intervention and examining changes in MMP genes. MMP gene polymorphism has recently been identified as one of the factors predicting susceptibility or risk in the development of oral carcinoma. This review aims to provide insight into the function of MMP subtypes involved in cancer. The genetic polymorphism in MMP genes and its predictive value in risk evaluation have been elaborated. Novel personalized therapeutic approaches for oral cancer, like the use of MMP inhibitors, nanoparticle-mediated targeting of MMP, or gene silencing by microRNA, can be designed.

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Matrix Metalloproteinases in Oral Cancer Pathogenesis and their Use in Therapy

Maurya,

Prasad,

Mukherjee

2024

ACAMC

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Zinc dyshomeostasis in secretory compartments promotes tumor growth and invasion via cell autonomous and non-autonomous autophagy

Cited by 1 publication

References 1 publication

Matrix Metalloproteinases in Oral Cancer Pathogenesis and their Use in Therapy

Matrix Metalloproteinases in Oral Cancer Pathogenesis and their Use in Therapy

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