Zinc, copper, and blood pressure: Human population studies

Carpenter, William E.; Lam, Derek J.; Toney, Glenn M.; Weintraub, Neal L.; Qin, Zhe

doi:10.12659/msm.883708

Cited by 35 publications

(27 citation statements)

References 38 publications

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“…Low serum zinc levels in observational studies correlate with hypertension as well as CHD, type Ⅱ DM, hyperlipidemia, elevated lipoprotein a [Lp(a)], increased 2 h postprandial plasma insulin levels and insulin resistance [90,91] . Zinc is transported into cardiac and vascular muscle and other tissues by metallothionein [92] .…”

Section: Zincmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Section: Zincmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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“…Low serum zinc (Zn ++ ) levels in observational studies correlate with hypertension as well as CHD . Zn ++ is transported into cardiac and vascular muscle and other tissues by metallothionein . Genetic deficiencies of metallothionein with intramuscular Zn ++ deficiencies may lead to hypertension .…”

Section: Zincmentioning

confidence: 99%

“…There is an inverse correlation of BP and serum Zn ++ ‐ and Zn ++ ‐dependent enzyme‐lysyl oxidase activity. Zn ++ inhibits gene expression and transcription through nuclear factor κ‐β and activated protein‐1 and is an important cofactor for superoxide dismutase . These effects as well as those on the renin‐angiotensin‐aldosterone system and sympathetic nervous system effects may account for Zn ++ antihypertensive effects .…”

Section: Zincmentioning

confidence: 99%

“…21 Genetic deficiencies of metallothionein with intramuscular Zn ++ deficiencies may lead to hypertension. 21 There is an inverse correlation of BP and serum Zn ++ -and Zn ++ -dependent enzymelysyl oxidase activity. Zn ++ inhibits gene expression and transcription through nuclear factor j-b and activated protein-1 and is an important cofactor for superoxide dismutase.…”

Section: Zincmentioning

confidence: 99%

“…21 These effects as well as those on the reninangiotensin-aldosterone system and sympathetic nervous system effects may account for Zn ++ antihypertensive effects. 21 Zn ++ intake should be 50 mg/d.…”

Section: Zincmentioning

confidence: 99%

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Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part II

Houston

2013

J of Clinical Hypertension

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Vascular biology, endothelial and vascular smooth muscle, and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease, and target organ damage. Nutrient‐gene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control, and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation, and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the select use of single and component nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension based on scientifically controlled studies, which complement optimal nutrition, coupled with other lifestyle modifications.

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Evolutionarily derived networks to inform disease pathways

Graham

Darabos

Huang

et al. 2017

Genetic Epidemiology

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Methods to identify genes or pathways associated with complex diseases are often inadequate to elucidate most risk because they make implicit and oversimplified assumptions about underlying models of disease etiology. These can lead to incomplete or inadequate conclusions. To address this, we previously developed human phenotype networks (HPN), linking phenotypes based on shared biology. However, such visualization alone is often uninterpretable, and requires additional filtering. Here, we expand the HPN to include another method, Evolutionary Triangulation (ET). ET utilizes the hypothesis that alleles affecting disease risk in multiple populations are distributed consistently with differences in disease prevalence and compares allele frequencies among populations and their relationship to phenotype prevalence. We hypothesized that combining these methods will increase our ability to detect genetic patterns of association in complex diseases. We combined HPN and ET to identify network patterns associated with Type 2 Diabetes Mellitus (T2DM), a leading causes of death worldwide. Fasting glucose, a continuous trait, was used as a proxy for T2DM and differs significantly among continental populations. The combined method identified several diabetes related traits and several phenotypes related to cardiovascular diseases, for which diabetes is a major risk factor. ET-HPN found more phenotypes related to our target and related phenotypes than the application of either method alone. Not only could we detect phenotype connections related to T2DM, but we also identified phenotypes that are distributed in parallel to it, e.g. Amyotrophic Lateral Sclerosis. Our analyses showed that ET filtered HPN provides information that neither technique can individually.

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Zinc, copper, and blood pressure: Human population studies

Cited by 35 publications

References 38 publications

The role of nutrition and nutraceutical supplements in the treatment of hypertension

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Nutrition and Nutraceutical Supplements for the Treatment of Hypertension: Part II

Evolutionarily derived networks to inform disease pathways

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