Zinc and Insulin Resistance: Biochemical and Molecular Aspects

Cruz, Kyria Jayanne Clímaco; Oliveira, Ana Raquel Soares de; Morais, Jennifer Beatriz Silva; Silva, Juliana; Mendes, Priscyla Maria Vieira; Melo, Stéfany Rodrigues de Sousa; Sousa, Gustavo Santos de

doi:10.1007/s12011-018-1308-z

Cited by 54 publications

(35 citation statements)

References 49 publications

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“…mRNA levels of many zinc transporters such as ZnT4, ZnT5, ZnT9, ZIPp1, ZIP4 and ZIP6 were significantly lower in obese women [ 116 ]. Related to that fact, plasmatic and erythroid zinc levels appeared to be significantly lower in obese children when compared to a control group, and urinary zinc secretion appeared higher, which may have some effect on insulin sensitivity, since zinc is involved in insulin secretion and action [ 117 , 118 ].…”

Section: Iron Metabolism In Obesitymentioning

confidence: 99%

Iron Metabolism in Obesity and Metabolic Syndrome

González-Domínguez

Visiedo-Garcia

Domínguez-Riscart

et al. 2020

IJMS

102

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Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity.

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Section: Iron Metabolism In Obesitymentioning

confidence: 99%

Iron Metabolism in Obesity and Metabolic Syndrome

González-Domínguez

Visiedo-Garcia

Domínguez-Riscart

et al. 2020

IJMS

102

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“…Indeed, Cd belongs to the same group of elements as zinc, and the number of common biological targets of the two metals abound [56][57][58][59][60]. The role of zinc in insulin regulation has been extensively examined [61][62][63]. Zinc associates with insulin in exocytosis granules, and a significant amount of zinc is subsequently released into the extracellular space.…”

Section: Insulin Resistance and Cadmium: Human Studiesmentioning

confidence: 99%

“…Defects in the transporters, such as SLC30A (ZNT) for the Zn provision for insulin secretion or SLC39A (ZIP) for replenishment, result in reduced intracellular zinc and a reduction in functional insulin release [62]. Changes in functional insulin release and alterations in zinc homeostasis may thus combine to contribute to glucose intolerance and IR [63].…”

Section: Insulin Resistance and Cadmium: Human Studiesmentioning

confidence: 99%

Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

Buha

Đukić-Ćosić

Ćurčić

et al. 2020

Toxics

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Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of “hyperglycemic” metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.

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“…Zinc is known in balancing the oxidant/anti-oxidant system and also in improving insulin resistance [42]. Furthermore, zinc and magnesium have direct and indirect effects on the secretion and signal transduction of insulin and in the development of insulin resistance [43,44]. Possibly, the complexed zinc or magnesium ion might be released from ZLB or MLB after intravenous injection into the rodents.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet

et al. 2020

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Excessive food consumption and insufficient exercise lead to the prevalence of metabolic syndrome in modern life, which consequently increases the risk of many chronic diseases. Magnesium lithospermate B (MLB) from Danshen has been demonstrated to improve metabolic changes in high-fat diet–fed rats with metabolic syndrome. In this study, Mg2+ in MLB was successfully replaced with Zn2+ to form zinc lithospermate B (ZLB) complex. MLB (10 mg/kg /day) and ZLB of various concentrations (1, 2.5, 5, and 10 mg/kg/day) were prepared and examined for their therapeutic effects on metabolic syndrome induced in rats fed with a high-fat diet. The results showed that both MLB and ZLB were able to recover or alleviate the abnormal physiological states of high-fat diet–fed rats including weight gain, epididymal fat accumulation, fatty liver, retarded blood lipid and glucose metabolism putatively caused by insulin resistance, and elevated levels of proinflammatory cytokine, leptin, and oxidative stress. In an overall view of the animal study, the effectiveness of ZLB supplementation seemed to be better than that of MLB supplementation for the recovery of high-fat-fed rats from metabolic syndrome.

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Zinc and Insulin Resistance: Biochemical and Molecular Aspects

Cited by 54 publications

References 49 publications

Iron Metabolism in Obesity and Metabolic Syndrome

Iron Metabolism in Obesity and Metabolic Syndrome

Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

Therapeutic Effects of Lithospermate B Complexed with Mg2+ or Zn2+ on Metabolic Syndrome Induced in Rats Fed with High-Fat Diet

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