Zinc Ameliorate Oxidative Stress and Hormonal Disturbance Induced by Methomyl, Abamectin, and Their Mixture in Male Rats

Abstract

Exposure to mixtures of toxicants (e.g., pesticides) is common in real life and a subject of current concern. The present investigation was undertaken to assess some toxicological effects in male rats following exposure to methomyl (MET), abamectin (ABM), and their combination (MET+ABM), and to evaluate the ameliorative effect of zinc co-administration. Three groups of rats were designated for MET, ABM, and the mixture treatments. Three other groups were designated for zinc in conjunction with the pesticides. Additionally, one group received water only (control), and the other represented a positive zinc treatment. The obtained results revealed that MET was acutely more toxic than ABM. The tested pesticides induced significant elevation in lipid peroxidation and catalase levels, while declined the levels of the other tested parameters e.g., Superoxide dismutase (SOD), Glutathione-S-transferase (GST), Glutathione peroxidase (GPx), Glutathione reductase (GR), Cytochrome P450 (CYP450), testosterone, and thyroxine). Biochemical alterations induced by the mixture were greater than those recorded for each of the individual insecticides. The joint action analysis, based on the obtained biochemical data, revealed the dominance of antagonistic action among MET and ABM. Zinc supplementation achieved noticeable ameliorative effects. It was concluded that zinc may act as a powerful antioxidant, especially in individuals who are occupationally exposed daily to low doses of such pesticides.

Evaluation The Effect of The Aqueous Extract of Green Tea on Renal Toxicity Induced by-Methomyl in Experimental Animals Model تقییم تاثر المستخلص المائی للشای الاخضر علی تسمم الکلی المستحدث بواسطه المیثومایل فی حیوانات التجارب

“…Carbamates are known to diminish activities of SOD and to elevate ROS. These obtained results of the present investigation agree with several studies, MET was reported to decrease the activity of SOD (Mansour et al, 2012(Mansour et al, , 2015(Mansour et al, , 2017b(Mansour et al, and 2019.…”

The Protective Effect of Moringa Tea Against Cypermethrin-Induced Hepatorenal Dysfunction, Oxidative Stress, and Histopathological Alterations in Female Rats

“…The hepatic and renal function results of the current study corroborated the histopathological lesions observed in the examined organs and supported by the results of Lamfon [62] and Mansour et al [59] who found that rats treated with deltamethrin have shown loss of normal structure of the hepatic cells, blood congestion, Kupffer cells activation, and hemorrhagic areas and degeneration in the renal tubules. Due to the ability of MO extracts to reduce the oxidative stress induced by toxicants, its high nutritional value could ameliorate and rejuvenate damages in several tissues including liver [63] and cerebral cortex [27,28].…”

“…Values of AI exceeding 1.0 may refer to either better improvement or negligible experimental errors. The obtained results are supported by our previously published investigations on other pesticides and different antioxidants [59,64,65].…”

“…Many pesticides may induce oxidative stress following acute exposure in humans [56] and animals [57]. Nevertheless, increased LPO in the tissues may be one of the molecular mechanisms involved in the toxicity of synthetic pyrethroids [58,59].…”

Green Tea Attenuates methomyl-Induced Cardiac Toxicity Through Modulating Oxidative Stress and Nuclear Factor kappa B Up- Regulation in Mice

“…These compounds have a rapid effect on the target pests and have a relatively short life in the environment [7]. According to the World Health Organization (WHO) [8], ME is classified as a severely hazardous compound (Class 1B) [9]. ME causes adverse effects on human health through the overproduction of ROS that builds up causing lipid peroxidation, and LPO causes the degradation of nucleoprotein, nucleic acid, and DNA fragmentation.…”