2017
DOI: 10.3390/toxics5040037 View full text |Buy / Rent full text
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Abstract: Exposure to mixtures of toxicants (e.g., pesticides) is common in real life and a subject of current concern. The present investigation was undertaken to assess some toxicological effects in male rats following exposure to methomyl (MET), abamectin (ABM), and their combination (MET+ABM), and to evaluate the ameliorative effect of zinc co-administration. Three groups of rats were designated for MET, ABM, and the mixture treatments. Three other groups were designated for zinc in conjunction with the pesticides. … Show more

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“…Carbamates are known to diminish activities of SOD and to elevate ROS. These obtained results of the present investigation agree with several studies, MET was reported to decrease the activity of SOD (Mansour et al, 2012(Mansour et al, , 2015(Mansour et al, , 2017b(Mansour et al, and 2019.…”
Section: Discussionsupporting
“…The hepatic and renal function results of the current study corroborated the histopathological lesions observed in the examined organs and supported by the results of Lamfon [62] and Mansour et al [59] who found that rats treated with deltamethrin have shown loss of normal structure of the hepatic cells, blood congestion, Kupffer cells activation, and hemorrhagic areas and degeneration in the renal tubules. Due to the ability of MO extracts to reduce the oxidative stress induced by toxicants, its high nutritional value could ameliorate and rejuvenate damages in several tissues including liver [63] and cerebral cortex [27,28].…”
Section: Discussionsupporting
“…Values of AI exceeding 1.0 may refer to either better improvement or negligible experimental errors. The obtained results are supported by our previously published investigations on other pesticides and different antioxidants [59,64,65].…”
Section: Discussionsupporting
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“…These compounds have a rapid effect on the target pests and have a relatively short life in the environment [7]. According to the World Health Organization (WHO) [8], ME is classified as a severely hazardous compound (Class 1B) [9]. ME causes adverse effects on human health through the overproduction of ROS that builds up causing lipid peroxidation, and LPO causes the degradation of nucleoprotein, nucleic acid, and DNA fragmentation.…”
Section: Introductionmentioning