volume 93, issue 0, P2-YIA-30 2020
DOI: 10.1254/jpssuppl.93.0_2-yia-30
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Abstract: AIM] M1 microglia influence astrocytic neuroprotective functions, including engulfment of cell debris. Recently, extracellular zinc has been shown to aggravate M1 phenotype in microglia through intracellular zinc accumulation and reactive oxygen species (ROS) generation. Here, we investigated whether zinc-enhanced M1 microglia affects the astrocytic engulfing activity.[METHODS] Mouse primary astrocytes were preincubated with microglial-conditioned medium (MCM) collected from M1 microglia induced by lipopolysac…

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