Zika virus: A new human teratogen? Implications for women of reproductive age

Schüler‐Faccini, Lavínia; Sanseverino, Mtv; Vianna, Fsl; Silva, AA da; Larrandaburu, Mariela; Marcolongo-Pereira, Clairton; Abeche, AM

doi:10.1002/cpt.386

Cited by 31 publications

(23 citation statements)

References 14 publications

(12 reference statements)

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“…The suspicion of a causal relationship between microcephaly and ZIKV, and the preliminary evidence of a specific clinical phenotype beyond isolated microcephaly in a study of 35 infants by Schuller‐Faccini et al, prompted us to study in greater detail the phenotypic spectrum of this newly recognized pattern of disruption, as well as to speculate regarding the underlying developmental pathogenesis (PAHO, ; Schuler‐Faccini, Ribeiro, et al, ; Schuler‐Faccini, Sanseverino, et al, ). Assuming the current evidence as sufficient for causality, the phenotypes described in these 83 infants most likely result from ZIKV prenatal infection of the embryo and fetus (Brasil, Pereira, Moreira, et al, ; de Araújo et al, ; França et al, ; Honein et al, ; Rasmussen, Jamieson, Honein, & Petersen, ; Schuler‐Faccini, Sanseverino et al, ). This study provides detailed insight into the range of the phenotypes observed in these infants.…”

Section: Discussionmentioning

confidence: 99%

The phenotypic spectrum of congenital Zika syndrome

Campo

Feitosa

Ribeiro

et al. 2017

American J of Med Genetics Pt A

184

183

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In October 2015, Zika virus (ZIKV) outbreak the Brazilian Ministry of Health (MoH). In response, the Brazilian Society of Medical Genetics established a task force (SBGM-ZETF) to study the phenotype of infants born with microcephaly due to ZIKV congenital infection and delineate the phenotypic spectrum of this newly recognized teratogen. This study was based on the clinical evaluation and neuroimaging of 83 infants born during the period from July, 2015 to March, 2016 and registered by the SBGM-ZETF. All 83 infants had significant findings on neuroimaging consistent with ZIKV congenital infection and 12 had confirmed ZIKV IgM in CSF. A recognizable phenotype of microcephaly, anomalies of the shape of skull and redundancy of the scalp consistent with the Fetal Brain Disruption Sequence (FBDS) was present in 70% of infants, but was most often subtle. In addition, features consistent with fetal immobility, ranging from dimples (30.1%), distal hand/finger contractures (20.5%), and feet malpositions (15.7%), to generalized arthrogryposis (9.6%), were present in these infants. Some cases had milder microcephaly or even a normal head circumference (HC), and other less distinctive findings. The detailed observation of the dysmorphic and neurologic features in these infants provides insight into the mechanisms and timings of the brain disruption and the sequence of developmental anomalies that may occur after prenatal infection by the ZIKV.

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Section: Discussionmentioning

confidence: 99%

The phenotypic spectrum of congenital Zika syndrome

Campo

Feitosa

Ribeiro

et al. 2017

American J of Med Genetics Pt A

184

183

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“…The clinical presentation of ZIKV embryopathy cases, including arthrogryposis, increased skin fold in the occipital region, alterations in neurological and imaging tests compatible with the classic clinical picture of ZIKV infection (brain calcification and delayed brain development) as described in the literature, was crucial for diagnosis 15,16 .…”

Section: Discussionmentioning

confidence: 98%

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

Friedrich

Herber

Terra

et al. 2019

CBR

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Introduction: Microcephaly is a clinical finding that can arise from congenital anomalies or emerge after childbirth. Maternal infections acquired during pregnancy can result in characteristic brain damage in the newborn (NB), which may be visible even in the fetal stage. To describe the epidemiological profile of newborns with reported microcephaly and diagnosed with congenital infections in the state of Rio Grande do Sul between 2015 and 2017. Methods: A cross-sectional study was carried out on data collected from the Public Health Event Registry as well as from medical records. The investigation included serologies for toxoplasmosis and rubella; polymerase chain reaction (PCR) for Zika virus (ZIKV) in the blood and cytomegalovirus in the urine; non-treponemal tests for syphilis; and brain imaging tests. Results: Of the 257 reported cases of microcephaly, 39 were diagnosed with congenital infections. Severe microcephaly was identified in 13 patients (33.3%) and 51.3% of the cases showed alterations in brain imaging tests. In relation to the diagnosis of congenital infections, three patients (7.7%) were diagnosed with ZIKV, nine (23.1%) with cytomegalovirus, nine (23.1%) with toxoplasmosis, and 18 (46.1%) with congenital syphilis. The three cases of ZIKV showed calcification in brain imaging tests, signs of arthrogryposis, excess occipital skin and irritability, characterizing the typical phenotype of ZIKV infection. Conclusions: Most cases of congenital infection had severe neurological lesions, particularly the cases of ZIKV, which can cause neurodevelopmental delays and sequelae in these infants throughout early childhood.

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“…Beside microcephaly, brain calcifications, cataracts and intraocular calcifications of eyes in fetuses are also reported [45]. In other cases, agyria, hydrocephalus and associated cortical displacement and mild focal inflammation are also present [46][47][48]. Similarly in another case in addition to the above-mentioned symptoms,…”

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confidence: 91%

Zika Virus, Microcephaly and its Possible Global Spread

Badshah¹,

Mabkhot²,

Ahmad³

et al. 2018

Current Topics in Zika

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Zika virus is an arbovirus that is spreading at an alarming state in the American continents and now in Asian countries. The Aedes mosquitoes are the vectors for the spread of this virus beside other ways of transmission. Currently, there are no vaccines or drugs available for its treatment. The Zika virus-related microcephaly cases are reported in fetuses of pregnant women who got this viral infection. However, the exact mechanism of Zika virus and microcephaly is still not established. Here we review Zika virus epidemiology, its unusual relationship with microcephaly in fetuses and current scientific research progress on it.not favorable for Aedes mosquitos [35]. In such areas, blood and semen donations should be properly checked for the presence of Zika virus, and further, people coming from affected areas should take care when they donate blood and semen in unaffected areas [36]. Relation between Zika virus and microcephalyMicrocephaly is one of the associated medical effects of Zika virus infection in mothers with their new born babies [36][37][38][39][40]. In the past, cases of Zika virus with microcephaly were not that common, but in Brazil, it was observed that the rate of microcephaly is twenty times more, which is quite alarming and new cases are still emerging [41]. Zika virus has the capacity to cross the placental barrier and infect the fetus [42,43]. The infected mothers of these babies have rashes in the first and second trimesters [44]. Beside microcephaly, brain calcifications, cataracts and intraocular calcifications of eyes in fetuses are also reported [45]. In other cases, agyria, hydrocephalus and associated cortical displacement and mild focal inflammation are also present [46][47][48]. Similarly in another case in addition to the above-mentioned symptoms,

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Zika virus: A new human teratogen? Implications for women of reproductive age

Cited by 31 publications

References 14 publications

The phenotypic spectrum of congenital Zika syndrome

The phenotypic spectrum of congenital Zika syndrome

Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017

Zika Virus, Microcephaly and its Possible Global Spread

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