Zeitschriften

Eauschardt,; Mündel,; Pauschardt,; Müller, A. Hermann; Oettel,; Klose,; Dinkler,; Zinn,; Fischer, W.; Koch,; Pendl,; Sperling,; Klein, S. R.; Bernhardt,

doi:10.1007/bf01777460

Cited by 1 publication

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“…More human lives have been lost to tuberculosis than to any other disease [1] and the disease is also of central importance to veterinary medicine. Since its isolation by Koch in 1882 [2], the human tubercle bacillus, Mycobacterium tuberculosis, has posed a formidable challenge to generations of biomedical researchers as a result of its long generation time, fastidious growth requirements and high risk of contagion. In the last decade, the ability to perform molecular genetic analysis of M. tuberculosis has resulted in powerful new research tools [3,4] while the availability of the complete genome sequence has provided us with a wealth of new information, knowledge and understanding of the biology of this major pathogen [5].…”

Section: Introductionmentioning

confidence: 99%

Learning from the genome sequence of Mycobacterium tuberculosis H37Rv

Cole

1999

FEBS Letters

120

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Mycobacterium tuberculosis, the scourge of humanity, is one of the most successful and scientifically challenging pathogens of all time. To catalyse the conception of new prophylactic and therapeutic interventions against tuberculosis, and to enhance our understanding of the biology of the tubercle bacillus, the complete genome sequence of the most widely used strain, H37Rv, has been determined. Bioinformatic analysis led to the identification of V V4000 genes in the 4.41 Mb genome sequence and provided fresh insight into the biochemistry, physiology, genetics and immunology of this much-feared bacterium. Genomic information is centralised in TubercuList

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Section: Introductionmentioning

confidence: 99%