Zein-based films and their usage for controlled delivery: Origin, classes and current landscape

Zhang, Yong; Cui, Lili; Che, Xin; Zhang, Heng; Shi, Nian-Qiu; Li, Chunlei; Chen, Yan; Kong, Wei

doi:10.1016/j.jconrel.2015.03.030

Cited by 179 publications

(101 citation statements)

References 112 publications

(233 reference statements)

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“…1 Among these, zein and zein-based carriers have drawn much attention from experts in both food and pharmaceutical fields due to its molecular characterization, cytocompatibility, and biodegradability. [2][3][4][5] Zein belongs to the class of prolamin proteins and is the main storage protein of maize. Zein is primarily present as protein bodies in endosperm cells and can be extracted and separated with various technologies.…”

Section: Introductionmentioning

confidence: 99%

“…Commercial zein usually refers to α-zein with a purity higher than 90%. Numerous studies have demonstrated that zein could be fabricated into various carriers, such as films, 3 nanofibers, 4 nano/microparticles, 8 nano/microcapsules, 9,10 and micelles. 11 These carriers and their biomedical applications have been reviewed recently.…”

Section: Introductionmentioning

confidence: 99%

“…11 These carriers and their biomedical applications have been reviewed recently. [3][4][5] Currently, although zein film coating for tablets and pellets is the only approved biomedical usage by the US Food and Drug Administration (FDA), other zein-based…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5] The fabrication of zein-based nano/microparticles can be realized with various methods, including chemical crosslinking, 12 antisolvent precipitation, 13 supercritical anti-solvent technique, 14 spray drying, 15,16 emulsification-solvent evaporation, 17 and emulsification-precipitation-gelation technique. 18 These methods involve different mechanisms and vary in their simplicity and scale-up potential.…”

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confidence: 99%

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Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

Li¹,

Yan²,

Liu³

et al. 2017

IJN

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Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, the fabrication of size-controlled zein particles has been a challenging issue. In this study, a modified anti-solvent precipitation method was developed, and the effects of various factors, such as mixing method, solvent/anti-solvent ratio, temperature, zein concentrations and the presence of sodium caseinate (SC) on properties of zein particles were investigated. Evidence is presented that, among the previously mentioned factors, the mixing method, especially mixing rate, could be used as an effective parameter to control the size of zein particles without changing other parameters. Moreover, through fine-tuning the mixing rate together with zein concentration, particles with sizes ranging from nanometers to micrometers and low polydispersity index values could be easily obtained. Based on the size-controlled fabrication method, SC-coated zein nanoparticles could also be obtained in a size-controlled manner by incubation of the coating material with the already-formed zein particles. The resultant nanoparticles showed better performance in both drug loading and controlled release, compared with zein/SC hybrid nanoparticles fabricated by adding aqueous ethanol solution to SC solution. The possible mechanisms of the nanoprecipitation process and self-assembly formation of these nanoparticles are discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

Li¹,

Yan²,

Liu³

et al. 2017

IJN

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“…Zein is approved as a generally recognized as safe (GRAS) excipient by the US Food and Drug Administration (FDA) for use in fi lm coatings for pharmaceuticals, medical devices, nanoparticles, nanofi bers and fi lms as delivery carrier [40]. Novel applications in biomedical materials, such as those used for the controlled and targeted delivery of bioactive chemicals and tissue engineering, are the main applications of these zein-based fi lms [33].…”

mentioning

confidence: 99%

Valorization of Agricultural Wastes for the Production of Protein-Based Biopolymers

Burgos¹,

Valdés²,

Jiménez³

2016

j renew mater

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In this study we provide an overview of the latest developments on the extraction, production, modifi cation and applications of fruit residues and by-products in the formation of protein-based biopolymers, in particular for the formulation of edible fi lms. Our aim was mainly to demonstrate the highly transdisciplinary character of these topics by giving an overview of the main developments and research topics in the chemistry and engineering aspects of protein-based biopolymers. These innovative raw materials have been evaluated for the production of biomaterials to be used in some key sectors, such as food packaging.

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Zein in Food Packaging

Bayer

2021

Sustainable Food Packaging Technology

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Zein-based films and their usage for controlled delivery: Origin, classes and current landscape

Cited by 179 publications

References 112 publications

Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

Valorization of Agricultural Wastes for the Production of Protein-Based Biopolymers

Zein in Food Packaging

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