Zebrafish Model for Safety and Toxicity Testing of Nutraceuticals

Bian, Wan-Ping; Pei, De‐Sheng

doi:10.1016/b978-0-12-802147-7.00025-5

Cited by 7 publications

(7 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 1997, the accumulation of TiO 2 NPs and the alteration of gene expression were studied by a zebrafish model (Danio rerio). The results revealed that long-term exposure to low concentrations of TiO 2 NPs is toxic to the reproductive system of this species [73]. Moreover, they concluded that long-term exposure of these nanoparticles is similar to that caused by many toxic reproductive substances, such as endocrine chemicals.…”

Section: Titanium Dioxide Nanoparticlesmentioning

confidence: 90%

“…Toxicity tests can be performed on cell cultures (in vitro) and in living organisms (in vivo) such as fish, mice, or rats [73,74]. There are several standardized toxicological tests that are available to assess the biological response of a chemical substance.…”

Section: Toxicity Testsmentioning

confidence: 99%

“…Since continental and marine waters would be the main receiving compartment, in vivo tests were mainly carried out in aquatic organisms that would reflect the impact of nanomaterials on the environment [73]. During the contact with animals, the variation of the NMs concentration allows to calculate statistically the indicators that will allow the comparison of toxicity between different nanomaterials and/or between nanomaterials and traditional chemical substances.…”

Section: Toxicity Testsmentioning

confidence: 99%

See 2 more Smart Citations

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

Zielińska

Costa

Ferreira

et al. 2020

IJERPH

135

View full text Add to dashboard Cite

This review offers a systematic discussion about nanotoxicology and nanosafety associated with nanomaterials during manufacture and further biomedical applications. A detailed introduction on nanomaterials and their most frequently uses, followed by the critical risk aspects related to regulatory uses and commercialization, is provided. Moreover, the impact of nanotoxicology in research over the last decades is discussed, together with the currently available toxicological methods in cell cultures (in vitro) and in living organisms (in vivo). A special focus is given to inorganic nanoparticles such as titanium dioxide nanoparticles (TiO2NPs) and silver nanoparticles (AgNPs). In vitro and in vivo case studies for the selected nanoparticles are discussed. The final part of this work describes the significance of nano-security for both risk assessment and environmental nanosafety. “Safety-by-Design” is defined as a starting point consisting on the implementation of the principles of drug discovery and development. The concept “Safety-by-Design” appears to be a way to “ensure safety”, but the superficiality and the lack of articulation with which it is treated still raises many doubts. Although the approach of “Safety-by-Design” to the principles of drug development has helped in the assessment of the toxicity of nanomaterials, a combination of scientific efforts is constantly urgent to ensure the consistency of methods and processes. This will ensure that the quality of nanomaterials is controlled and their safe development is promoted. Safety issues are considered strategies for discovering novel toxicological-related mechanisms still needed to be promoted.

show abstract

Section: Titanium Dioxide Nanoparticlesmentioning

confidence: 90%

Section: Toxicity Testsmentioning

confidence: 99%

Section: Toxicity Testsmentioning

confidence: 99%

See 1 more Smart Citation

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

Zielińska

Costa

Ferreira

et al. 2020

IJERPH

135

View full text Add to dashboard Cite

show abstract

“…Most importantly, its genomes are strikingly homologous to human genes31. Up to now, zebrafish has been used as a model to study cardiovascular diseases32, drug screening and validation33, DNA damage and repair34 as well as the toxicity testing353637. The fish at early developmental stages are very susceptive to toxic substances, so the embryo is more accurate and appropriate for assessing the toxicity, the transport and biocompatibility of xenobiotics38.…”

mentioning

confidence: 99%

In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish

Zhang

Niu

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

Carbon quantum dots (CDs) were widely investigated because of their tunable fluorescence properties and low toxicity. However, so far there have been no reports on in vivo functional studies of hair and skin derived CDs. Here, hair derived CDs (HCDs) and skin derived CDs (SCDs) were produced by using human hair and pig skin as precursors. The quantum yields (QYs) of HCDs and SCDs were quite high, compared to citric acid derived CDs (CCDs). HCDs and SCDs possess optimal photostability, hypotoxicity and biocompatibility in zebrafish, indicating that HCDs and SCDs possess the capacity of being used as fluorescence probes for in vivo biological imaging. The long-time observation for fluorescence alternation of CDs in zebrafish and the quenching assay of CDs by ATP, NADH and Fe3+ ions demonstrated that the decaying process of CDs in vivo might be induced by the synergistic effect of the metabolism process. All results indicated that large batches and high QYs of CDs can be acquired by employing natural and nontoxic hair and skin as precursors. To our knowledge, this is the first time to report SCDs, in vivo comparative studies of HCDs, SCDs and CCDs as bioprobes, and explore their mechanism of photostability in zebrafish.

show abstract

“…Considerando essas vantagens, o modelo experimental com embriões de zebrafish vem ganhando cada vez mais espaço, sendo um dos organismos padrões que mais cresce em publicações científicas (GARCIA et al, 2016). Além de ser usado para avaliações dentro da toxicologia ambiental, os experimentos com embriões de zebrafish têm sido empregados para ensaios de segurança e toxicidade de produtos nutracêuticos, estudos relacionados a diversas doenças, como doença de Parkinson, distúrbios renais e doenças cardiovasculares, além de ser também uma ótima alternativa para análises na fase de screening de novos medicamentos, visando investigação de possível ação teratogênica (BIAN et al, 2016;BRETAUD et al, 2004;DOOLEY,K. ;ZON, L., 2000;GIACOMINI et al, 2006).…”

Section: Presença De Fármacos Psicotrópicos No Ambienteunclassified

Avaliação dos efeitos deletérios de fármacos psicotrópicos sobre o desenvolvimento dos estágios embrio-larvais de zebrafish

Prado¹

View full text Add to dashboard Cite

Zebrafish Model for Safety and Toxicity Testing of Nutraceuticals

Cited by 7 publications

References 59 publications

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

In vivo characterization of hair and skin derived carbon quantum dots with high quantum yield as long-term bioprobes in zebrafish

Avaliação dos efeitos deletérios de fármacos psicotrópicos sobre o desenvolvimento dos estágios embrio-larvais de zebrafish

Contact Info

Product

Resources

About