Zearalenone induces chromosome aberrations in mouse bone marrow: preventive effect of 17β-estradiol, progesterone and Vitamin E

Ouanes, Zouhour; Ayed-Boussema, Imen; Baâti, Tarek; Creppy, E. E.; Bacha, Hassen

doi:10.1016/j.mrgentox.2004.10.005

Cited by 80 publications

(53 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering that zearalenone's action mechanism is not clear and different pathways other than its estrogenic activity are under investigation, experiments were performed in order to determine if zen and α-zen could affect the genetic material of spermatozoa as it occurs in lymphocytes, bone marrow cells, Vero and Caco-2 cells (Abid-Essefi et al, 2004;Lioi et al, 2004;Ouanes et al, 2005). On the basis of these considerations, the aim of the present study was to investigate the in vitro effects zen and α-zen on sperm nuclear chromatin integrity of boars.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of zearalenone and α‐zearalenol toxicity on boar sperm DNA integrity

Tsakmakidis

Lymberopoulos

Khalifa

et al. 2008

J of Applied Toxicology

View full text Add to dashboard Cite

This study aimed at investigating the in vitro effects of zearalenone (zen) and alpha-zearalenol (alpha-zen) on motility and nuclear chromatin integrity (NCI) of boar spermatozoa. Mycotoxins were tested, at levels ranging from 10 to 30 microg ml(-1) of diluted semen. Four boars were used for semen collection (eight replicates per boar, four per mycotoxin). After the addition of zen or alpha-zen, semen samples were incubated for 4 h at 38.5 degrees C, 5% CO(2) and 96% humidified air. Motility and NCI were assessed at 0 and 4 h of incubation. No significant differences were noticed in motility among the experimental groups (P > 0.05) for all tested boars. Chromatin instability was significantly higher (P < 0.05) in spermatozoa of only one boar treated with zen and alpha-zen independently of the dose. In conclusion, under our experimental conditions, zen and alpha-zen did not affect the motility of boar sperm, whereas the effects of these toxins on sperm NCI were individual-dependent.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of zearalenone and α‐zearalenol toxicity on boar sperm DNA integrity

Tsakmakidis

Lymberopoulos

Khalifa

et al. 2008

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…93 ZEN ve metabolitlerinin DNA katım ürünleri ve DNA lezyonları-nın oluşumunu artırdığı, mikroçekirdek ve DNA hata oluşum sıklığını artırdığı in vivo (fare kemik iliği hücreleri) ve in vitro (Çin hamster ovaryum hücreleri, Vero, DOK ve Caco-2 hücreleri) birçok çalışmada rapor edilmiştir. 88,[94][95][96][97] ZEN ve metabolitlerinin genotoksik etkilerinin, kromozom aberasyon testi ile karşılaştırıldığı bir diğer araş-tırmada; ZEN ve α-zearelenol (ZOL)'un β-ZOL'ye göre daha fazla DNA hasarına neden olduğu in vivo (Balb/c fareleri) ve in vitro (İnsan servikal karsinoma hücreleri, HeLa) olarak gösterilmiştir. 98 ZEN ve metabolitlerinin (α-ZOL ve β-ZOL) insan meme bezlerinde östrojen reseptörlerini uyardığı, çeşitli proteinlerin ekspresyonunu düzenleyerek apoptozu inhibe ettiği ve meme karsinoma hücreleri-nin (MCFF-7) proliferasyonunu artırdığına ilişkin çalışmalar mevcut olsa da IARC tarafından Grup III karsinojen olarak listelenmiştir.…”

Section: Zearalenonlarunclassified

Genotoxic Effects of Mycotoxins: Review

Beci̇t¹,

Aydın²,

Baydar³

2017

Turkiye Klinikleri J Pharm Sci

View full text Add to dashboard Cite

senobiyotiklere maruziyet sonucunda DNA'da meydana gelen kalıcı değişikliklere "mutasyon" denir. Mutasyon, genotoksik etkinin nihai bir sonucudur. DNA molekülünde oluşan başlıca primer DNA hasarları; DNA sarmalındaki tek ve çift iplik kırıklarını, DNA bazları ve proTurkiye Klinikleri J Pharm Sci 2017;6(2):59-76 59Mikotoksinlerin Genotoksik Etkileri Ö ÖZ ZE ET T Mikotoksinler, hem insan ve hayvan sağlığına olumsuz etkilere hem de ciddi ekonomik kayıplara neden olmaları açısından önemli riskler taşımaktadır. Mikotoksinlere maruziyet, asıl olarak kontamine yem ve gıdaların tüketilmesi ile olup, inhalasyon veya dermal yolla da temas söz konusu olabilmektedir. Mikotoksinler insan sağlığı üzerinde karaciğer, böbrek, bağışıklık, üreme ve gelişme sistemi gibi birçok organ ve sistemi olumsuz yönde etkileyebilmekte, düşük doz ancak kronik maruziyetlerinde özellikle genotoksik ve karsinojenik etkileri ile kansere yol açabilmektedir. Gı-dalarda önemli risk oluşturan mikotoksinler arasında Aspergillus, Penicillium, Fusarium ve Alternaria türlerinin oluşturduğu metabolitler yer almaktadır. Bu metabolitler arasında aflatoksinler, okratoksinler, zearalenon, trikotesenler, fusarium ve yeni keşfedilen fusarium mikotoksinler, patulin, alternaria toksinleri ve ergot alkaloitleri yer almaktadır. Günümüzde bazı mikotoksinlerin genotoksik olduğu artık bilinmektedir. Mikotoksinlerin genotoksik etki mekanizmalarına yönelik araştırmalar halen devam etmektedir. Her ne kadar in vitro çalışmalarda bazı mikotoksinlerin genotoksik etkileri gösterilmiş olsa da bu etkilerin in vivo koşullarla desteklenmesi, etki mekanizmalarının aydınlatılması ve epidemiyolojik çalışmalarla daha ileri değerlendirilmesi gerekmektedir. Bu derleme makalesinde, ekonomik kayıplara yol açan, toplum ve hayvan sağlığı için riskleri olan ve gıda kirleticileri olarak sık karşılaşılan mikotoksinlerin neden olduğu genetik hasarlardan ve bu hasarın olası mekanizmalarından bahsedilecektir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Aflatoksinler; mutajenler; okratoksinler; mikotoksinler; patulin; mutajenlik testleri; fusarium; alternaria; ergotamin A AB BS S T TR RA AC CT T Mycotoxins have significant risks in terms of their adverse effects on human and animal health and causing serious economic losses. Exposure to mycotoxins is primarily through the consumption of contaminant feed and food, which may be through the inhalation or dermal route. Mycotoxins can adversely affect many organs and systems such as liver, kidney, immune system, reproductive and developmental system on human health. In low dose but chronic exposures, especially it can cause cancer with genotoxic and carcinogenic effects. Mycotoxins reveal significant risks in terms of both adverse effects on human and animal health and serious economic loss. Mycotoxins, which have significant risks in food, include metabolites of Aspergillus, Penicillium, Fusarium and Alternaria species, These metabolites include aflatoxins, ochratoxins, zearalenone, tricothecenes, fusarium and emerged fusarium mycotoxins...

show abstract

“…Zearalenone is not commonly fatal but can induce abortion and other breeding problems. Studies have demonstrated that ZEN exposure is associated with carcinogenic, genotoxic, and immunotoxic effects in animals and humans (Ouanes et al, 2005;Tomaszewski et al, 1998;Zinedine et al, 2007;Liu et al, 2014). Female pigs have been found to be particularly susceptible to ZEN.…”

Section: Introductionmentioning

confidence: 99%

Effects of Modified Maifanite on Zearalenone Toxicity in Female Weaner Pigs

Chen

Hou

et al. 2015

Italian Journal of Animal Science

View full text Add to dashboard Cite

The experiment was conducted to investigate alleviative effects of modified maifanite (MMF) on zearalenone (ZEN) toxicity in female weaner pigs. In this experiment, 32 female weaner pigs (Duroc×Landrace×Large white, 10.50±0.07 kg) were divided into 4 groups (8 pigs/group): control group (0.02 mg/kg ZEN); ZEN-treated group (1.11 mg/kg ZEN); MMF-treated group (1% MMF); ZEN+MMF treated group (1.11 mg/kg ZEN and 1% MMF), The trial period lasted for 28 d. Growth performance, vulva size, genital organs, antioxidant enzyme activities, serum metabolites and ZEN residues in female weaner pigs were determined. The results showed that the treatments had no effect on growth performance and length and width of the vulva. However, vulva area (P=0.038) and progesterone (P=0.022) were affected by the ZEN×MMF interaction. Treatment with ZEN resulted in a significant increase of the genital organ weight (P=0.002) and decrease of serum superoxide dismutase (P=0.017) activity. Feeding of the ZEN diet decreased the number of red blood cells (P=0.009) and platelets (P=0.002). The MMF reduced methane dicarboxylic aldehyde concentration when fed with ZEN diet but not when fed with the basal diet (ZEN×MMF, P=0.018). In the liver, feeding of the ZEN diet with MMF reduced the levels of ZEN residues (P=0.003). Our findings suggest that the addition of MMF to ZEN diet resulted in partial restoration of antioxidant status and reduced ZEN levels in the liver.

show abstract

Zearalenone induces chromosome aberrations in mouse bone marrow: preventive effect of 17β-estradiol, progesterone and Vitamin E

Cited by 80 publications

References 45 publications

Evaluation of zearalenone and α‐zearalenol toxicity on boar sperm DNA integrity

Evaluation of zearalenone and α‐zearalenol toxicity on boar sperm DNA integrity

Genotoxic Effects of Mycotoxins: Review

Effects of Modified Maifanite on Zearalenone Toxicity in Female Weaner Pigs

Contact Info

Product

Resources

About