Zalecenia Polskiego Towarzystwa Chorób Płuc Dotyczące Rozpoznawania i Leczenia Przewlekłej Obturacyjnej Choroby Płuc

Śliwiński, Paweł; Górecka, Dorota; Jassem, Ewa; Pierzchała, Władysław

doi:10.5603/piap.2014.0030

Cited by 59 publications

(52 citation statements)

References 217 publications

(234 reference statements)

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“…Both groups differed in the results of lung function tests (Table 1). Patients with hyperinflation had a lower pre and post-bronchodilator FEV 1 . Pre-bronchodilator FVC was also lower, however there were no differences in post-bronchodilator FVC.…”

Section: Resultsmentioning

confidence: 92%

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Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Rubinsztajn¹,

Przybyłowski²,

Maskey-Warzęchowska³

et al. 2015

Advances in Respiratory Medicine

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Correlation between hyperinflation defined as an elevated RV/TLC ratio and body composition and cytokine profile in patients with chronic obstructive pulmonary disease Korelacje pomiędzy rozdęciem miąższu płucnego mierzonego wskaźnikiem RV%TLC i składem ciała oraz profilem cytokinowym u chorych na przewlekłą obturacyjną chorobę płucThe study was performed as the part of National Center for Research and Development project "Chronic obstructive pulmonary disease (COPD) -systemic disease, the biggest threat of XXI century" (NO. 13 0034 06/2009). AbstractIntroduction: Body composition is an important prognostic factor in patients with COPD. The decrease in fat free mass (FFM), muscle mass (MM) and increase in visceral fat is associated with an elevated secretion of cytokines which promote systemic inflammation. The aim of the study was to evaluate body composition and the cytokine profile in patients with COPD in relation with the presence of hyperinflation. Material and methods:The study group consisted of 149 patients (61F, 88M) with stable COPD in all stages of severity aged 68 ± 8.8 yrs. All the patients underwent spirometry and bodypletysmography with bronchial reversibility testing. Hyperinflation was defined as RV%TLC > 48% and > 126% predicted. Body composition was analyzed by bioimpedance. The following serum inflammatory markers were evaluated: C-reactive protein, IL-6, IL-8, TNF-a, CC16, adiponectin and resistin. Results: Hyperinflation was found in 96 patients (group A) and it was more frequent in women than men (49/61 vs. 47/88, p < 0.001). BMI and age in this group were comparable to those in patients without hyperinflation (group B). Patients with hyperinflation have lover FFM, FFM index, MM and MM index and total body water and higher fat mass and fat mass index. We found significantly higher serum concentrations of inflammatory markers in group A: IL-6 -6.4 ± 10.9 vs. 3.6 ± 4.2 pg/ml, resistin -9.3 ± 4.2 vs. 7.6 ± 2.4 ng/ml, CRP 4.1 ± 2.3 vs. 2.9±2.1 mg/l, respectively. Conclusions: Patients with hyperinflation have a lower FFMI, TBW and MMI and a higher proportion of fat tissue. Hyperinflation is associated with elevated concentrations of inflammatory markers what may be associated with more severe disease. Body compositions abnormality and higher activity of systemic inflammation could therefore be a negative prognostic factor in COPD patients.

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Section: Resultsmentioning

confidence: 92%

“…Chronic obstructive pulmonary disease is characterized by progressive airflow limitation which is a result an inflammatory response in the airways to noxious particles and gases [1]. Pathological changes that lead to airway obstruction may have the form of chronic bronchitis and/or pulmonary emphysema.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Rubinsztajn¹,

Przybyłowski²,

Maskey-Warzęchowska³

et al. 2015

Advances in Respiratory Medicine

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“…The GOLD criterion has been criticized because it leads to significant overdiagnosis of COPD in elderly people and insufficient number of diagnoses in younger subjects (especially smokers) [18]. Therefore, many prestigious scientific societies, including the Polish Respiratory Society, advise to use the LLN of the FEV 1 /FVC ratio as cut-off threshold [19]. The percentage of tobacco smokers among patients with diagnosed respiratory diseases is a major source of concern.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Prevention Program in the Proszowice County: Description and Results

Skucha¹,

Mejza

Nadziakiewicz

et al. 2017

Advances in Respiratory Medicine

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Introduction: In the Proszowice county, both lung cancer and chronic obstructive pulmonary disease (COPD) are more common in comparison with other regions of Poland. The purpose of this paper was to provide a report on a prevention program carried out in the area to reduce the burden of COPD and lung cancer in the region. Material and methods:The program consisted of the following: active prevention -questionnaire survey offered to every county inhabitant aged at least 40 and chest X-ray and spirometry performed in selected subjects; and passive preventioncovering multiple educational activities promoting healthy lifestyle. Data obtained from questionnaire survey and spirometry were further analyzed. Results: Education program covered all local children aged 13-15, a majority of adolescents and a significant proportion of adult inhabitants of the county. Questionnaire data were obtained from 14,455 subjects (about 70% of county inhabitants). On the basis of the questionnaire results, the participants were selected to undergo spirometry (5,816 subjects) and chest X-ray (5,514 subjects). Current smokers constituted 24.2% of the total number of participants (33.3% of men and 16.8% of women). Electronic cigarettes were currently used by 0.65% of the subjects. Negative impact of occupational exposures (including farming) on lung function and the presence of respiratory symptoms was observed. Basing on post-bronchodilator spirometry, COPD was diagnosed in 13.2% of the subjects. Physician's diagnosis of asthma was reported by 7.2%. Conclusion: Educational activities and questionnaire-based study were targeted at and reached the majority of the county inhabitants. The study provided data on the prevalence and risk factors of COPD, asthma and respiratory symptoms in the Proszowice region.

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“…The same observation could be made when comparing the global GOLD document to various local (national) recommendations all over the world, which all move towards personalised medicine, i.e. tailoring treatment to individual patients' characteristics [1][2][3][4][5][6][7][8][9][10][11]. This raises an important question: should local bodies put effort, energy and funds in the development of guidelines when well-documented global proposals already exist, and could be adopted as they are?…”

Section: Narrative Summarymentioning

confidence: 99%

Pharmacological treatment optimisation for stable COPD: an endless story?

et al. 2017

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Zalecenia Polskiego Towarzystwa Chorób Płuc Dotyczące Rozpoznawania i Leczenia Przewlekłej Obturacyjnej Choroby Płuc

Abstract: Pierwsze krajowe “Zalecenia postępowania w przewlekłej obturacyjnej chorobie płuc (POChP)” powstały w 1998 roku z inicjatywy profesorów Jana Zielińskiego i Józefa Małolepszego oraz dr. hab [...]

Cited by 59 publications

References 217 publications

Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Pulmonary Prevention Program in the Proszowice County: Description and Results

Pharmacological treatment optimisation for stable COPD: an endless story?

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