Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications

Abstract

Magnetic nanoparticles of Fe 3 O 4 doped by different amounts of Y 3+ (0, 0.1, 1, and 10%) ions were designed to obtain maximum heating efficiency in magnetic hyperthermia for cancer treatment. Single-phase formation was evident by X-ray diffraction measurements. An improved magnetization value was obtained for the Fe 3 O 4 sample with 1% Y 3+ doping. The specific absorption rate (SAR) and intrinsic loss of power (ILP) values for prepared colloids were obtained in water. The best results were estimated for Fe 3 O 4 with 0.1% Y 3+ ions (SAR = 194 W/g and ILP = 1.85 nHm 2 /kg for a magnetic field of 16 kA/m with the frequency of 413 kHz). The excellent biocompatibility with low cell cytotoxicity of Fe 3 O 4 :Y nanoparticles was observed. Immediately after magnetic hyperthermia treatment with Fe 3 O 4 :0.1%Y, a decrease in 4T1 cells’ viability was observed (77% for 35 μg/mL and 68% for 100 μg/mL). These results suggest that nanoparticles of Fe 3 O 4 doped by Y 3+ ions are suitable for biomedical applications, especially for hyperthermia treatment.

Cancer nanotechnology: current status and perspectives

“…Hyperthermia (localized heat to kill cells) is a promising method for elimination of cancerous tissue, and certain nanomaterials have been shown to enhance hyperthermal effects [ 355 , 356 ]. Uniform and selective hyperthermia can be achieved using nanomaterials with a high-absorption cross-section, which can convert an external energy source into heat [ 357 , 358 ].…”

Electromagnetically Stimuli-Responsive Nanoparticles-Based Systems for Biomedical Applications: Recent Advances and Future Perspectives

“…Firstly, it is possible to produce NPs with higher magnetization properties. For example, in 2020 Kowalik et al [ 88 ] produced iron oxide NPs with different percentages of yttrium (from 0.1% to 10%), and they reported differences in terms of the magnetic properties (hence heating capability) and cytotoxicity of the systems. Interestingly, an increase of over 60% of the heating capability was recorded with a 0.1% inclusion of yttrium in the system, which probably affected the crystalline structure and in turn, indirectly, the magnetic characteristics.…”

Synthesis of mesoscopic particles of multi-component rare earth permanent magnet compounds

“…Once the R amounts in these encapsulated nanostructures are under the critical concentration for the solid-solution formation, the R-doped T-O nanostructures can be synthesized by using procedures which are similar to the above [81][82][83][84][85]. A series of Rdoped Fe 2 O 3 or Fe 3 O 4 (R=Sm, Eu, Gd, Tb, Ho, Er, Y) NPs with different shapes and particle sizes tuned in the range of 5 nm-1 m could be obtained by thermal decomposition [82][83][84], hydrothermal reaction [85], and ultrasonication [86]. These NPs were usually prepared by reductive thermal decomposition [87], solvothermal reaction [88], co-precipitation [89][90][91][92][93][94][95][96], and ultrasonication [97].…”