YR/DFO@DCNT functionalized anisotropic micro/nano composite topography scaffolds for accelerating long-distance peripheral nerve regeneration

Zheng, Tiantian; Wu, Linliang; Xu, Jiawei; Sun, Shaolan; Guan, Wenchao; Han, Qi; Zhang, Luzhong; Gu, Xiaodong; Yang, Yumin; Li, Guicai

doi:10.1016/j.compositesb.2022.110242

Cited by 15 publications

(4 citation statements)

References 54 publications

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“…The scaffold framework could mimic the interwoven myocardial anatomical structure, while the aligned electrospinning nanofiber network is able to guide cell alignment in a targeted manner. Moreover, a study was reported in which a nerve catheter was designed with poly(lactide-co-ε-caprolactone) (PLCL) nanofibers by electrospinning and gelatin hydrogel by 3D printing [50] . The formed PLCL nanofilms possess a transparent pore structure and can be applied as flexible external nerves for nerve conduits.…”

Section: Electrospinningmentioning

confidence: 99%

Hierarchically structured biomaterials for tissue regeneration

Ma,

Yang,

et al. 2024

Microstructures

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Repairing tissue defects caused by diseases and traumas presents significant challenges in the clinic. Recent advancements in biomaterials have offered promising strategies for promoting tissue regeneration. In particular, the exploration of 3D macro and microstructures of biomaterials has proven crucial in this process. The integration of macro, micro, and nanostructures facilitates the performance of biomaterials in terms of their mechanical properties, degradation rate, and distinctive impacts on cellular activities. In this review, we summarize the recent progress in biomaterials with hierarchical structures for tissue regeneration. We explore the various methods and strategies employed in designing biomaterials with hierarchical structures of different dimensions. The improvement of physicochemical properties and bioactivities by hierarchically structured biomaterials, including the regulation of mechanical properties, degradability, and the specific functions of cell behaviors, has been highlighted. Furthermore, the current applications of hierarchically structured biomaterials for tissue regeneration are discussed. Finally, we conclude by summarizing the developments of hierarchically structured biomaterials for tissue regeneration and provide future perspectives.

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Section: Electrospinningmentioning

confidence: 99%

Hierarchically structured biomaterials for tissue regeneration

Ma,

Yang,

et al. 2024

Microstructures

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“…Anisotropic topographic microgroove is another fascinating morphology to influence nerve regeneration. [ 7,228,229 ] A myriad of manufacturing technologies such as dry‐jet wet spinning, [ 230 ] macro‐modeling and lyophilization, [ 231 ] photolithography, and micro‐molding [ 232 ] have been utilized to fabricate microgrooves with refined structure. Exploring the effect of microgroove on PNR no less than changing its size, hardness, and shape.…”

Section: Morphology Cue‐based Strategies For Pnrmentioning

confidence: 99%

Physical Cue‐Based Strategies on Peripheral Nerve Regeneration

Wei

Jin

et al. 2022

Adv Funct Materials

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Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine. Recently, physical cue-based strategies (e.g., electrical neurostimulation, acoustic radiation, electromagnetic bioregulation, as well as directional fiber guiding, etc.) have drawn increasing attention not only as a stimulator for cell functions modulation and fate determination, but also as a morphology-index for modulating cell phenotype, proliferation, and differentiation, especially for nerve cells. More importantly, the advanced percutaneous power transmission technology, self-power nanotechnology that leverages piezoelectrical/triboelectricity materials, and focused ultrasound and pulsed electromagnetic field technology exhibit the appealing practice potential for achieving low-invasive, wireless, and battery-free neuromodulation. In this review, recent advances of physical cue-based strategies including electrical, acoustic, magnetic, and morphology for PNI are systematically overviewed, and the open challenges for realizing scalable clinical/commercial transformation and future perspectives of these strategies for PNI are concluded.

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“…We previously prepared porous chitosan conduit with longitudinally aligned structures on the intraluminal wall using the freeze-drying method, and the conduit was proved to significantly promote the regeneration of sciatic nerves in the 10 mm gap of the rat [ 27 ]. Preparation of micro/nano fiber scaffolds by electrospinning has been widely used in tissue engineering [ 28 , 29 ]. Nanofiber structures are more conducive to cell adhesion and proliferation as well as loading of bioactive factors than micron-sized fiber structures [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Development of ovalbumin implants with different spatial configurations for treatment of peripheral nerve injury

Zheng,

Gao,

Liu

et al. 2024

Bioactive Materials

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YR/DFO@DCNT functionalized anisotropic micro/nano composite topography scaffolds for accelerating long-distance peripheral nerve regeneration

Cited by 15 publications

References 54 publications

Hierarchically structured biomaterials for tissue regeneration

Hierarchically structured biomaterials for tissue regeneration

Physical Cue‐Based Strategies on Peripheral Nerve Regeneration

Development of ovalbumin implants with different spatial configurations for treatment of peripheral nerve injury

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